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排序方式: 共有382条查询结果,搜索用时 15 毫秒
81.
82.
M Wong A Kong S Constantine R Pathi FJ Parrish R Verma C Lim C Steer 《Journal of Medical Imaging and Radiation Oncology》2009,53(1):1-12
Small bowel carcinoid tumours are endocrine tumours of the gastrointestinal tract. This pictorial essay will review the pathology, clinical features, treatment and prognosis and illustrate the radiographic, computed tomographic, sonographic, magnetic resonance and nuclear medicine appearances of small bowel carcinoid tumours. 相似文献
83.
Two cases of globoid cell leukodystrophy (Krabbe's disease) have been studied by means of conventional histological, immunohistochemical and ultrastructural methods. Lectins specific for several different carbohydrates, Ricinus communis (RCA-1), peanut agglutinin (PNA), wheat germ agglutinin (WGA) and Concanavalin A (Con A) have been utilized both at optical and ultrastructural level. In both cases a strong positive labeling of the globoid cells could be observed light-microscopically. Ultrastructurally immunogold deposits only of RCA-I and WGA in the typical Krabbe's inclusions have been clearly demonstrated. 相似文献
84.
Fatty acid composition of fertilization-failed human oocytes 总被引:2,自引:2,他引:0
Matorras R; Ruiz JI; Mendoza R; Ruiz N; Sanjurjo P; Rodriguez-Escudero FJ 《Human reproduction (Oxford, England)》1998,13(8):2227-2230
85.
云南甘草中新三萜成分的研究 总被引:9,自引:0,他引:9
自云南甘草(Clycyrrhiza yunnanensis)根中分离出10个化合物,经化学方法和光谱解析,鉴定9个为五环三萜类化合物:3β,21α,24-三羟基-齐墩果-12-烯-29-羧酸(Ⅰ)、3β,21α-二羟基-齐墩果-12-烯(Ⅱ)、3β,21α,24-三羟基-齐墩果-12-烯(Ⅲ)、桦木酸(Ⅳ)、23-羟基桦木酸(Ⅴ)、齐墩果酸(Ⅵ)、3β-羟基-16-氧-11,13(18)-二烯-3O-羧酸(Ⅶ)、24-羟基甘草内酯(Ⅷ)和21α-乙酰氧基木栓烷-3-酮(Ⅸ);另一个为β-胡萝卜甙(Ⅹ)。其中Ⅰ和Ⅱ为新化合物,分别命名为云南甘草皂甙元B1和B2。其余7个是已知物,但Ⅴ和Ⅸ首次得自甘草属植物,Ⅳ,Ⅵ和Ⅷ首次自云南甘草中分离得到。 相似文献
86.
We describe a rare case of familial Cushing's disease occurring in a 7-year-old boy, and 19 years of follow up. Our patient first presented soon after his maternal aunt had been treated for Cushing's disease. The clinical presentation was made complicated by the development of an intercurrent eating disorder resembling anorexia nervosa. This resulted in marked weight loss, and even though serum and urinary cortisol levels were elevated, many of the clinical stigmata of Cushing's disease were absent. Eating disorders are relatively uncommon in boys, and in this case there was an organic cause for the abnormal behaviour. This case shows, furthermore, that even the obesity of Cushing's disease can be overcome by the combination of diet and exercise. 相似文献
87.
88.
A Hofer AS Hassan FJ Legat H Kerl P Wolf 《Journal of the European Academy of Dermatology and Venereology》2006,20(5):558-564
BACKGROUND: The treatment with XeCl-excimer laser generated 308-nm UVB radiation has shown promising results in patients with vitiligo. OBJECTIVE: In this controlled, prospective trial we studied the primary efficacy (start and grade of repigmentation) and patient's satisfaction of XeCl-excimer laser for treatment of vitiligo patches at different body sites and re-evaluated the achieved repigmentation 12 months after the end of therapy. METHODS: Twenty-five patients with generalized or localized vitiligo with a total of 85 lesions at different body sites were enrolled in this study. Vitiligo patches were treated with 308-nm XeCl-excimer laser 3 times a week for 6 to 10 weeks. The overall repigmentation grade of each treated lesion was evaluated once a week on a 5 point scale rating from 0 (no repigmentation), 1 (1-5%), 2 (6-25%), 3 (26-50%), 4 (51-75%), to 5 (76-100%). RESULTS: Twenty-four patients completed the study. Within 6 to 10 weeks of treatment 67% of the patients (16/24) developed follicular repigmentation of at least one of their vitiligo lesions. Lesion repigmentation started after a mean of 13 treatments in lesions located on the face, trunk, arm, and/or leg (high-responder location), and after a mean of 22 treatments in lesions located on the elbow, wrist, dorsum of the hand, knee, and/or dorsum of the foot (low-responder location). Untreated control lesions and lesions located on the fingers did not achieve any repigmentation. After 10 weeks of treatment repigmentation of more than 75% was found in 25% (7/28) of lesions of the high-responder location group versus 2% (1/43) of lesions of the low-responder location group. In most cases, laser-induced repigmentation was persistent, as determined 12 months after the end of treatment. CONCLUSIONS: 308-nm excimer laser is an effective modality for the treatment of vitiligo. However, similar to other non-surgical treatment modalities, the therapeutic effect is mainly dependent on the location of vitiligo lesions. 相似文献
89.
Pulkkinen L; Smith FJ; Shimizu H; Murata S; Yaoita H; Hachisuka H; Nishikawa T; McLean WH; Uitto J 《Human molecular genetics》1996,5(10):1539-1546
In a distinct autosomal recessive variant of epidermolysis bullosa, EB- MD,
life-long skin blistering is associated with late-onset muscular dystrophy
of unknown etiology. Electron microscopy of these patients' skin suggests
that tissue separation occurs intracellularly at the level of the
hemidesmosomal inner plaque, which contains plectin, a high molecular
weight cytoskeletal associated protein, also expressed in the sarcolemma of
the muscle. In this study, we report two patients with EB-MD, each with a
homozygous deletion mutation in the plectin gene, PLEC1. In the first case,
the proband and her similarly affected sister had a homozygous 9 bp
deletion mutation, designated as 2719de19, which resulted in elimination of
three amino acids, QEA, in a sequence of 23 amino acids entirely conserved
between the mouse and human sequences. The proband in the second family
demonstrated a single nucleotide deletion at position 5866, designated as
5866delC, which resulted in frameshift and a premature termination codon
for translation 16 bp downstream from the site of deletion. The absence of
plectin in the hemidesmosomes, as reflected by negative immunofluorescence
with an anti-plectin antibody (HD-1), associated with fragility of basal
keratinocytes, implicates plectin as critical for binding of intermediate
keratin filament network to hemidesmosomal complexes. The function of
plectin as a putative attachment protein also in the muscle would explain
the clinical phenotype consisting of cutaneous fragility and muscular
dystrophy in EB-MD.
相似文献
90.
The polymerase chain reaction (PCR) technique has become an important, widely employed method for the detection and quantitation of the nucleic acid sequences used in the diagnosis and monitoring of genetic and infectious diseases. Much attention has been directed at the problem of false-positive PCR results, which are generally attributed to low-level laboratory contamination of amplified sequences ("carryover"). In contrast, few investigators have commented on the somewhat less frequent, but equally problematic, false-negative PCR results. Investigation of the source of sporadic false-negative PCR reactions found that glove powder, inadvertently introduced into tubes when gloves are changed in an effort to reduce false-positive results, can nonspecifically inhibit each of the major steps in the PCR detection process. Methodologic precautions are recommended to minimize this problem. 相似文献