A study on improvement of expression of human G－CSF cDNA transferred with retroviral double－copy vector

ＡｓｔｕｄｙｏｎｉｍｐｒｏｖｅｍｅｎｔｏｆｅｘｐｒｅｓｓｉｏｎｏｆｈｕｍａｎＧ－ＣＳＦｃＤＮＡｔｒａｎｓｆｅｒｒｅｄｗｉｔｈｒｅｔｒｏｖｉｒａｌｄｏｕｂｌｅ－ｃｏｐｙｖｅｃｔｏｒＧｕｏＢａｏｙｕ（郭葆玉）；ＺｈａｎｇＳｕｙｉｎｇ（张淑英）；ＸｕＨｕｉ...     

高度近视合并青光眼患者视神经纤维层厚度的变化

目的:通过光学相干断层成像(OCT)检测高度近视合并青光眼患者视神经纤维层厚度的变化规律。方法:选取2017-01/12于我院进行治疗的高度近视合并青光眼患者80例160眼作为观察组,并选择同期于我院进行体检的健康志愿者60例120眼作为对照组。采用OCT分析所有受检者视神经纤维层厚度。结果:与对照组受检者相比,观察组患者鼻侧、颞上、鼻下、鼻上、颞下及全周平均视神经纤维层厚度均降低,而颞侧视神经纤维层厚度升高(P<0.05),且观察组中屈光度-10.00^-11.00D的患者鼻侧、颞上、鼻下、鼻上、颞下及全周平均视神经纤维层厚度均显著高于屈光度≥-12.00D的患者(P<0.05)。Spearman相关分析结果显示,观察组患者屈光度的绝对值与鼻侧、颞上、鼻下、颞下及全周平均厚度视神经纤维层厚度呈负相关,与颞侧视神经纤维层厚度呈正相关。结论:高度近视合并青光眼患者除颞侧外各象限视神经纤维层变薄。     

Community nephrology: audit of screening for renal insufficiency in a high risk population.

BACKGROUND: The rate of acceptance onto dialysis programmes has doubled in the past 10 years and is steadily increasing. Early detection and treatment of renal failure slows the rate of progression. Is it feasible to screen for patients who are at increased risk of developing renal failure? We have audited primary care records of patients aged 50-75 years who have either hypertension or diabetes, and are therefore considered to be at high risk of developing renal insufficiency. Our aim was to see whether patients had had their blood pressure measured and urine tested for protein within 12 months, and plasma creatinine measured within 24 months. METHODS: This was a retrospective study of case notes and computer records in 12 general practices from inner and greater London. A total of 16,855 patients were aged 50-75 years. From this age group, 2693 (15.5%) patients were identified as being either hypertensive or diabetic, or both. RESULTS: Of the 2561 records audited, 1359 (53.1%) contained a plasma creatinine measured within 24 months, and 11% of these (150) had a value > 125 micromol/l. This equates to a prevalence of renal insufficiency of > 110,000 patients per million in this group. Forty two patients (28%) had been referred to a nephrologist. Of records audited, 73% contained a blood pressure measurement and 29% contained a test for proteinuria within 12 months. CONCLUSIONS: There is a high prevalence of chronic renal insufficiency in hypertensive and diabetic patients. It is feasible to detect renal insufficiency at a primary care level, but an effective system will require computerized databases that code for age, ethnicity, measurement of blood pressure and renal function, as well as diagnoses.     

晚期前列腺癌的诊断与治疗(附41例报告)

目的:提高晚期前列腺癌的治疗效果。方法:回顾性分析采用睾丸切除术、内分泌治疗、放射治疗和同位素治疗等综合治疗的41例晚期前列腺癌患者资料。结果:41例经随访3～12个月,尿路梗阻症状均有不同程度改善,前列腺明显缩小,血清前列腺特异性抗原迅速降低,骨痛缓解。结论:积极的综合治疗能明显提高患者的生活质量