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101.
102.
Fernando Pretel Rute M Gon?alves-de-Andrade Fabio Carlos Magnoli Maria Esther R da Silva Jorge M C Ferreira Carmen W van den Berg Denise V Tambourgi 《Toxicon》2005,45(4):449-458
Loxosceles adelaida spiders (Araneae, Sicariidae) are found near and inside the caves in the Parque Estadual Turistico do Alto Ribeira (PETAR), Sao Paulo, Brazil, which are visited by thousands of tourists every year. Several Loxosceles species are a public health problem in many regions of the world, by causing severe dermonecrosis and/or complement dependent haemolysis upon envenomation. The aim of this study was to characterize the biochemical and biological properties of L. adelaida venom and evaluate the toxic potential of envenomation by this non-synanthropic Loxosceles species. The biological activities of the L. adelaida venom was compared to that of Loxosceles gaucho, a synanthropic species of medical importance in Brazil. L. adelaida venom showed a similar potential to induce haemolysis, dermonecrosis and lethality as L. gaucho venom. L. adelaida crude venom was purified, yielding a 31 kDa component endowed with haemolytic and dermonecrotic activities. In conclusion, we show here that the troglophile Loxosceles species, L. adelaida, commonly found in the complex of caves from PETAR, is potentially able to cause envenomation with the same gravity of those produced by synanthropic species. 相似文献
103.
We conducted a meta-analysis of randomized controlled clinical trials on steroid treatment for multiple sclerosis and optic
neuritis. Of the 25 trials comparing steroids and controls without steroid treatment that we identified 12 were selected for
this review. A meta-analysis was conducted to calculate the overall odds ratio across the studies for the numbers of patients
without functional improvement and with new relapses. The trials included a total of 1714 patients: 998 with multiple sclerosis
and 716 with optic neuritis. Any type of corticosteroids or adrenocorticotropic hormone (ACTH) treatment was considered, as
was any dosage, route of administration, and length of treatment. Main outcome measures were: (a) number of multiple sclerosis
patients who did not improve by at least one point on the EDSS or equivalent scale, or number of optic neuritis patients without
complete recovery of visual acuity at 8 or 30 days and at longer follow-up; (b) number of multiple sclerosis patients with
at least one new relapse, or number of optic neuritis patients in whom definite multiple sclerosis was diagnosed at longer
follow-up. We found that corticosteroids or ACTH produced a significant improvement in disability or visual acuity at 30 days
(odds ratio 0.49; 95 % CI 0.37–0.64). The improvement was not statistically significant at longer follow-up (0.85; 95 % CI
0.67–1.09). The treatment did not significantly reduce the number of patients with relapses (0.74; 95 % CI 0.54–1.01). Both
low and high doses were effective for 30-day improvement, but only high-dose and short-term therapy were factors that identified
subgroups with some reduction in the risk of new relapse. However, the power of the statistical analysis to detect a reliable
difference in the subgroups was low. Steroid treatment is therefore effective in accelerating short-term recovery in patients
with multiple sclerosis or optic neuritis. Whether steroids are also effective in reducing the risk of relapse, and the optimal
dose and length of treatment must still be determined.
Received: 5 August 1999, Received in revised form: 29 December 1999, Accepted: 22 January 2000 相似文献
104.
Fabio Scopesi Silvana Canini Cesare Arioni Massimo Mazzella Diego Gazzolo Pasquale B Lantieri Wanda Bonacci Giovanni Serra 《The journal of maternal-fetal & neonatal medicine》2006,19(6):343-346
BACKGROUND: Recently we demonstrated an increased 2,3-diphosphoglycerate (2,3-DPG) erythrocyte concentration in rat pups subjected to nucleotide-enriched artificial feeding. DESIGN: The present study was carried out to test the hypothesis that a possible increase in 2,3-DPG concentration can also be obtained in human neonates who are fed nucleotide-enriched formula. Preterm neonates born or referred to the neonatal intensive care unit of the G. Gaslini Hospital, Genoa University, with a gestational age >30 weeks and <37 weeks were enrolled in our randomized trial. Recruitment took place within 48-72 hours from birth. Only newborns of mothers deciding not to breast-feed were eligible to be randomized for the supplemented group (FN) or non-supplemented group (RF). Breast-fed newborns were considered the control group (C). The study window (for supplementation and blood samples) was restricted to the first two weeks following birth (from the 2nd (t1) to the 16th (t2) day of life). At the end of our study, only 21 neonates were eligible for statistical analysis. RESULTS: The stimulating action of dietary nucleotides on 2,3-DPG concentration failed to be demonstrated; increases in 2,3-DPG concentration that were observed in newborns fed with nucleotide supplemented formula (FN) were comparable to those observed in newborns fed with regular formula (RF) and breast-fed newborns. CONCLUSIONS: The EC recommendation for the amount of nucleotides allowed in formula milk does not seem to be high enough to have positive effects on 2,3-DPG synthesis. Whether this possible 'pharmacological' effect can be achieved by a higher intake of ingested nucleotides and/or a change in the proportions of single nucleotides contained in milk formulas remain interesting end points to be elucidated. 相似文献
105.
Int6 expression can predict survival in early-stage non-small cell lung cancer patients. 总被引:1,自引:0,他引:1
106.
107.
108.
Andra Araujo Brando Weimar Kunz Sebba Barroso Audes Feitosa Eduardo Costa Duarte Barbosa Roberto Dischinger Miranda Priscila Valverde de Oliveira Vitorino Roberto Pozzan Lucio Paulo Ribeiro Abraham Epelman Giovanni Alves Saraiva Fabio Serra Silveira Antnio Almeida Braga Marco Mota Gomes 《Arquivos brasileiros de cardiologia》2022,119(2):353
109.
Debora Soncini Claudia Martinuzzi Pamela Becherini Elisa Gelli Samantha Ruberti Katia Todoerti Luca Mastracci Paola Contini Antonia Cagnetta Antonella Laudisi Fabio Guolo Paola Minetto Maurizio Miglino Sara Aquino Riccardo Varaldo Daniele Reverberi Matteo Formica Mario Passalacqua Alessio Nencioni Antonino Neri Mehmet K. Samur Nikhil C. Munshi Mariateresa Fulciniti Roberto M. Lemoli Michele Cea. 《Haematologica》2022,107(6):1410
110.
Silvia Bianchi Maria Gori Clara Fappani Giulia Ciceri Marta Canuti Daniela Colzani Marco Dura Mara Terraneo Anna Lamberti Melissa Baggieri Sabrina Senatore Marino Faccini Fabio Magurano Elisabetta Tanzi Antonella Amendola 《Viruses》2022,14(5)
Despite the existence of an effective live-attenuated vaccine, measles can appear in vaccinated individuals. We investigated breakthrough measles cases identified during our surveillance activities within the measles/rubella surveillance network (MoRoNet) in Milan and surrounding areas (Northern Italy). Between 2017 and 2021, we confirmed measles virus (genotypes B3 or D8) infections in 653 patients and 51 of these (7.8%) were vaccinees. Among vaccinated individuals whose serum was available, a secondary failure was evidenced in 69.4% (25/36) of cases while 11 patients (30.6%) were non-responders. Non-responders were more frequently hospitalized and had significantly lower Ct values in both respiratory and urine samples. Median age and time since the last immunization were similar in the two groups. Importantly, we identified onward transmissions from vaccine failure cases. Vaccinees were involved in 20 outbreaks, in 10 of them they were able to transmit the virus, and in 8 of them, they were the index case. Comparing viral hemagglutinin sequences from vaccinated and non-vaccinated subjects did not show a specific mutation pattern. These results suggest that vaccination failure was likely due to the poor immune response of single individuals and highlights the importance of identifying breakthrough cases and characterizing their clinical and virologic profiles. 相似文献