全文获取类型
收费全文 | 5462篇 |
免费 | 359篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 104篇 |
儿科学 | 327篇 |
妇产科学 | 174篇 |
基础医学 | 740篇 |
口腔科学 | 120篇 |
临床医学 | 525篇 |
内科学 | 913篇 |
皮肤病学 | 129篇 |
神经病学 | 634篇 |
特种医学 | 202篇 |
外科学 | 765篇 |
综合类 | 48篇 |
一般理论 | 1篇 |
预防医学 | 367篇 |
眼科学 | 189篇 |
药学 | 296篇 |
中国医学 | 11篇 |
肿瘤学 | 296篇 |
出版年
2023年 | 48篇 |
2022年 | 90篇 |
2021年 | 177篇 |
2020年 | 93篇 |
2019年 | 180篇 |
2018年 | 195篇 |
2017年 | 161篇 |
2016年 | 172篇 |
2015年 | 218篇 |
2014年 | 248篇 |
2013年 | 352篇 |
2012年 | 425篇 |
2011年 | 388篇 |
2010年 | 242篇 |
2009年 | 175篇 |
2008年 | 323篇 |
2007年 | 316篇 |
2006年 | 303篇 |
2005年 | 274篇 |
2004年 | 231篇 |
2003年 | 194篇 |
2002年 | 193篇 |
2001年 | 48篇 |
2000年 | 42篇 |
1999年 | 43篇 |
1998年 | 28篇 |
1997年 | 20篇 |
1996年 | 20篇 |
1995年 | 12篇 |
1993年 | 13篇 |
1992年 | 16篇 |
1991年 | 12篇 |
1936年 | 10篇 |
1934年 | 9篇 |
1933年 | 14篇 |
1932年 | 12篇 |
1931年 | 13篇 |
1930年 | 15篇 |
1929年 | 15篇 |
1928年 | 19篇 |
1927年 | 18篇 |
1926年 | 16篇 |
1925年 | 22篇 |
1924年 | 24篇 |
1923年 | 16篇 |
1922年 | 16篇 |
1921年 | 10篇 |
1911年 | 11篇 |
1908年 | 9篇 |
1905年 | 9篇 |
排序方式: 共有5841条查询结果,搜索用时 15 毫秒
41.
Jae-Yung Kwon Lara Russell Theresa Coles Robert J. Klaassen Kara Schick-Makaroff Kathryn M. Sibley Sandra A. Mitchell Richard Sawatzky 《Current oncology (Toronto, Ont.)》2022,29(5):3093
Tools for measuring patients’ perceived health and quality of life, such as patient-reported outcome measures (PROMs), inform clinical decisions for patients requiring radiation therapy. However, there may be inconsistencies in how patients interpret and respond to PROMs due to cultural, environmental, personal, or experiential factors. Differential item functioning (DIF) and response shift (RS) refer to differences in the meaning of PROMs between patients or over time (respectively). DIF and RS can threaten the accurate interpretation and use of PROMs, potentially resulting in erroneous conclusions about effectiveness, and flawed individual-level clinical decision-making. Given the empirical evidence of DIF and RS, we aim to review clinical implications and solutions for addressing DIF and RS by providing vignettes from collaborative examinations with workshop participants, as well as the literature. By making these methodological concepts accessible and relevant, for practice, clinicians may feel more confident to ask clarifying questions of patients when PROM scores and the contextual patient information do not align. PROM scores need to be interpreted via dialogue with the patient to avoid misinterpretation due to DIF and RS, which could diminish patient–clinician communication and impede shared decision-making. This work is part of an interdisciplinary knowledge translation initiative focused on the interpretation of PROM scores by clinically-oriented audiences. 相似文献
42.
Eren Erdogdu Berker Ozkan Salih Duman Melek Agkoc Sukru Mehmet Erturk Murat Kara Alper Toker 《The clinical respiratory journal》2022,16(5):361
BackgroundThe management of a solitary pulmonary nodule is a challenging issue in pulmonary disease. Although many factors have been defined as predictors for malignancy in solitary pulmonary nodules, the accurate diagnosis can only be established with the permanent histological diagnosis.ObjectiveWe tried to clarify the possible predictors of malignancy in solitary pulmonary nodules in patients who had definitive histological diagnosis.MethodsWe made a retrospective study to collect the data of patients with solitary pulmonary nodules who had histological diagnosis either before or after surgery. We made a statistical analysis of both the clinic and radiological features of these nodules with respect to malignancy both in contingency tables and with logistic regression analysis.ResultsWe had a total of 223 patients with a radiological diagnosis of solitary pulmonary nodule. Age, smoking status and pack years of smoking, maximum standardized uptake value (SUVmax), and radiological features such as solid component, spiculation, pleural tag, lobulation, calcification, and higher density were significant predictors of malignancy in contingency tables. Age, smoking status and smoking (pack/year), SUVmax, and radiological features including spiculation, pleural tag, lobulation, calcification, and higher density were the significant predictors in univariate analysis. However, multivariate analysis revealed only SUVmax greater than 2.5 (p < 0.0001), spiculation (p = 0.009), and age older than 61 years (p = 0.015) as the significant predictors for malignancy.ConclusionAge, SUVmax, and spiculation are the independent predictors of malignancy in patients with solitary pulmonary nodules. 相似文献
43.
Rudy S. Suidan Caryn M. St. Clair Stephen J. Lee Joyce N. Barlin Kara C. Long Roche Edward J. Tanner Yukio Sonoda Richard R. Barakat Oliver Zivanovic Dennis S. Chi 《Gynecologic oncology》2014
Objective
To compare survival outcomes for patients with advanced epithelial ovarian cancer (EOC) who received primary intravenous/intraperitoneal (IV/IP) chemotherapy to those who received IV followed by consolidation (treatment given to patients in remission) IP chemotherapy.Methods
Data were analyzed and compared for all patients with stage III–IV EOC who underwent optimal primary cytoreduction (residual disease ≤ 1 cm) followed by cisplatin-based consolidation IP chemotherapy (1/2001–12/2005) or primary IV/IP chemotherapy (1/2005–7/2011).Results
We identified 224 patients; 62 (28%) received IV followed by consolidation IP chemotherapy and 162 (72%) received primary IV/IP chemotherapy. The primary IP group had significantly more patients with serous tumors. The consolidation IP group had a significantly greater median preoperative platelet count, CA-125, and amount of ascites. There were no differences in residual disease at the end of cytoreduction between both groups. The median progression-free survival (PFS) was greater for the primary IP group; however, this did not reach statistical significance (23.7 months vs 19.7 months; HR 0.78; 95% CI, 0.57–1.06; p = 0.11). The median overall survival (OS) was significantly greater for the primary IP group (78.8 months vs 57.5 months; HR 0.56; 95% CI, 0.38–0.83; p = 0.004). On multivariate analysis, after adjusting for confounders, the difference in PFS was not significant (HR 0.78; 95% CI, 0.56–1.11; p = 0.17), while the difference in OS remained significant (HR 0.59; 95% CI, 0.39–0.89; p = 0.01).Conclusions
In our study, primary IV/IP chemotherapy was associated with improved OS compared to IV followed by consolidation IP chemotherapy in patients with optimally cytoreduced advanced EOC. 相似文献44.
Jiraporn Kara Paptawan Suwanhom Chatchai Wattanapiromsakul Teerapat Nualnoi Jindaporn Puripattanavong Pasarat Khongkow Vannajan Sanghiran Lee Anand Gaurav Luelak Lomlim 《Archiv der Pharmazie》2019,352(7)
Sixteen novel coumarin‐based compounds are reported as potent acetylcholinesterase (AChE) inhibitors. The most active compound in this series, 5a (IC50 0.04 ± 0.01 µM), noncompetitively inhibited AChE with a higher potency than tacrine and galantamine. Compounds 5d , 5j , and 5 m showed a moderate antilipid peroxidation activity. The compounds showed cytotoxicity in the same range as the standard drugs in HEK‐293 cells. Molecular docking demonstrated that 5a acted as a dual binding site inhibitor. The coumarin moiety occupied the peripheral anionic site and showed π‐π interaction with Trp278. The tertiary amino group displayed significant cation‐π interaction with Phe329. The aromatic group showed π‐π interaction with Trp83 at the catalytic anionic site. The long chain of methylene lay along the gorge interacting with Phe330 via hydrophobic interaction. Molecular docking was applied to postulate the selectivity toward AChE of 5a in comparison with donepezil and tacrine. Structural insights into the selectivity of the coumarin derivatives toward huAChE were explored by molecular docking and 3D QSAR and molecular dynamics simulation for 20 ns. ADMET analysis suggested that the 2‐(2‐oxo‐2H‐chromen‐4‐yl)acetamides showed a good pharmacokinetic profile and no hepatotoxicity. These coumarin derivatives showed high potential for further development as anti‐Alzheimer agents. 相似文献
45.
46.
Outcome of children and adolescents with Down syndrome treated on Dana‐Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium protocols 00–001 and 05‐001
下载免费PDF全文
![点击此处可从《Pediatric blood & cancer》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Uma H. Athale Maneka Puligandla Kristen E. Stevenson Barbara Asselin Luis A. Clavell Peter D. Cole Kara M. Kelly Caroline Laverdiere Jean‐Marie Leclerc Bruno Michon Marshall A. Schorin Maria Luisa Sulis Jennifer J. G. Welch Marian H. Harris Donna S. Neuberg Stephen E. Sallan Lewis B. Silverman 《Pediatric blood & cancer》2018,65(10)
47.
48.
49.
50.
Elze-Rostock v. Jaschke Dietlen G. Rosenow Gottschalk Grassheim Magnus-Alsleben Oppenheimer Dietrich Lewy Noxhmann Bernhardt Griesbach Peiper Oscar Gans J. Jadassohn Br. Bloch Erich Langer Jaffé Heyn Finkenrath K. Hirschfeld Simon Valentin Mendel O. Wiener Eugen Kahn Kronfeld 《Journal of molecular medicine (Berlin, Germany)》1928,7(7):321-327
Ohne Zusammenfassung 相似文献