全文获取类型
收费全文 | 833篇 |
免费 | 60篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 43篇 |
妇产科学 | 1篇 |
基础医学 | 98篇 |
口腔科学 | 23篇 |
临床医学 | 37篇 |
内科学 | 257篇 |
皮肤病学 | 2篇 |
神经病学 | 167篇 |
特种医学 | 27篇 |
外科学 | 130篇 |
综合类 | 2篇 |
预防医学 | 9篇 |
眼科学 | 2篇 |
药学 | 16篇 |
中国医学 | 1篇 |
肿瘤学 | 82篇 |
出版年
2024年 | 3篇 |
2023年 | 11篇 |
2022年 | 6篇 |
2021年 | 11篇 |
2020年 | 9篇 |
2019年 | 11篇 |
2018年 | 17篇 |
2017年 | 20篇 |
2016年 | 21篇 |
2015年 | 36篇 |
2014年 | 31篇 |
2013年 | 27篇 |
2012年 | 45篇 |
2011年 | 49篇 |
2010年 | 24篇 |
2009年 | 24篇 |
2008年 | 46篇 |
2007年 | 63篇 |
2006年 | 65篇 |
2005年 | 67篇 |
2004年 | 57篇 |
2003年 | 66篇 |
2002年 | 56篇 |
2001年 | 4篇 |
2000年 | 5篇 |
1999年 | 9篇 |
1998年 | 13篇 |
1997年 | 12篇 |
1996年 | 10篇 |
1995年 | 7篇 |
1994年 | 4篇 |
1993年 | 4篇 |
1992年 | 5篇 |
1991年 | 5篇 |
1990年 | 4篇 |
1989年 | 8篇 |
1988年 | 5篇 |
1987年 | 2篇 |
1986年 | 3篇 |
1985年 | 7篇 |
1984年 | 2篇 |
1982年 | 3篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1978年 | 6篇 |
1976年 | 2篇 |
1973年 | 1篇 |
1964年 | 1篇 |
1962年 | 1篇 |
1961年 | 1篇 |
排序方式: 共有899条查询结果,搜索用时 31 毫秒
31.
Masanori Tokunaga Yutaka Tanizawa Etsuro Bando Taiichi Kawamura Masanori Terashima 《Annals of surgical oncology》2013,20(5):1575-1583
Background
The impact of postoperative complications on recurrence rate and long-term outcome has been reported in patients with colorectal and esophageal cancer, but not in patients with gastric cancer. This study evaluated the impact of postoperative intra-abdominal infectious complications on long-term survival following curative gastrectomy.Methods
This study included 765 patients who underwent curative gastrectomy for gastric cancer between 2002 and 2006. Patients were divided into 2 groups: with (C-group, n = 81) or without (NC-group, n = 684) intra-abdominal infectious complications. Survival curves were compared between the groups, and multivariate analysis was conducted to identify independent prognostic factors.Results
Male patients were dominant, and total gastrectomy was frequently performed in the C-group. The pathological stage was more advanced and D2 lymph node dissection and splenectomy were preferred in the C-group. The 5-year overall survival (OS) rate was better in the NC-group (86.8 %) than in the C-group (66.4 %; P < .001). The 5-year relapse-free survival (RFS) rate was also better in the NC-group (84.5 %) than in the C-group (64.9 %; P < .001). This trend was still observed in stage II and III patients after stratification by pathological stage. Multivariate analysis identified intra-abdominal infectious complication as an independent prognostic factor for OS (hazard ratio, 2.448; 95 % confidence interval [95 % CI], 1.475–4.060) and RFS (hazard ratio, 2.219; 95 % CI, 1.330–3.409) in patients with advanced disease.Conclusions
Postoperative intra-abdominal infectious complications adversely affect OS and RFS. Meticulous surgery is needed to decrease the complication rate and improve the long-term outcome of patients following curative gastrectomy. 相似文献32.
This study investigated the effect of the immersion of alginate impressions in 0.5% sodium hypochlorite solution for 15 min on the dimensional changes of stone models designed to simulate a sectional form of a residual ridge. Five brands of alginate impression materials, which underwent various dimensional changes in water, were used. A stone model made with an impression that had not been immersed was prepared as a control. The immersion of two brands of alginate impressions that underwent small dimensional changes in water did not lead to serious deformation of the stone models, and the differences in the dimensional changes between the stone models produced with disinfected impressions and those of the control were less than 15 μm. In contrast, the immersions of three brands of alginate impressions that underwent comparatively large dimensional changes in water caused deformation of the stone models. 相似文献
33.
34.
35.
To understand the genetic origin of I2020T mutation in the kinase domain of leucine rich repeat kinase 2 (LRRK2), we investigated the original PARK8 Japanese family (Sagamihara family) and a German family (family 32), both of which were found to harbor I2020T as the causal mutation for autosomal dominant familial Parkinson's disease (PD). Microsatellite-haplotype analysis around the LRRK2 gene indicated that the mutation-carrying haplotypes of the two families were distinct from each other. This indicated that the I2020T mutation, an essential pathogenic mutation of PARK8-related PD, had occurred independently in the two PD families. 相似文献
36.
Takamichi Ishii Etsuro Hatano Kentaro Yasuchika Kojiro Taura Satoru Seo Shinji Uemoto 《Surgery today》2014,44(10):1900-1905
Purpose
The relationship between the tumor size and organs of recurrence was analyzed to identify a high-risk group for the extrahepatic recurrence of hepatocellular carcinoma (HCC) after resection.Methods
A total of 544 patients with HCC underwent primary surgical resection for HCC between 2001 and 2010. Of these, 293 patients had a solitary tumor but no macroscopic vascular invasion. The prognostic factors for the overall survival and relapse-free survival were analyzed among these 293 patients. The recurrent organs and frequency of recurrence were also examined.Results
The analysis of the 293 patients showed that both the overall and relapse-free survival rates of the patients with a large tumor (>7 cm in diameter) were significantly worse than those of the patients with a tumor <7 cm. The incidence of lung metastasis was remarkably high in the group of patients with tumors more than 7 cm (24.0 %), in comparison to those with tumors <7 cm. A multivariate analysis revealed that the tumor size was the only independent risk factor for lung metastasis.Conclusions
The patients with large HCC tumors more than 7 cm in diameter were at high-risk for a poor prognosis due to a high percentage of lung metastasis, even if there was no macroscopic vascular invasion. 相似文献37.
38.
Kitazawa J Tono C Terui K Kinukawa N Oda M Isoyama K Ishii E Ito E;Japan Infant Leukemia Study Group 《International journal of hematology》2005,81(5):428-432
Although infants with acute lymphoblastic leukemia (ALL) and MLL gene rearrangements have a poor prognosis, those with acute myeloid leukemia (AML) have been shown to have a superior outcome with intensive chemotherapy alone despite the presence of MLL gene rearrangements. We report the case of an ALL infant with t(9;11), a common cytogenetic abnormality in infant AML, who after relapse underwent successful hematopoietic stem cell transplantation (HSCT) from her HLA 2-loci-mismatched mother. Analysis of the outcome among ALL infants with MLL gene rearrangements registered in the Japan Infant Leukemia Study between 1996 and 1999 showed the event-free survival of patients with t(9;11) was not different from that of those with other 11q23 translocations. Most of the patients with t(9;11) described in the reviewed literature also experienced either induction failure or early relapse after achievement of complete remission, but some of them were rescued with subsequent HSCT. These findings suggest that infant ALL with t(9;11) has features distinct from those of infant AML with the same karyotype and that the prognosis among these patients can be improved only with the combination of intensive chemotherapy and HSCT An appropriate strategy for the treatment of ALL infants with different 11q23 translocations must be clarified. 相似文献
39.
Hirotoshi Sakaguchi Nobuhiro Nishio Asahito Hama Nozomu Kawashima Xinan Wang Atsushi Narita Sayoko Doisaki Yinyan Xu Hideki Muramatsu Nao Yoshida Yoshiyuki Takahashi Kazuko Kudo Hiroshi Moritake Kazuhiro Nakamura Ryoji Kobayashi Etsuro Ito Hiromasa Yabe Shouichi Ohga Akira Ohara Seiji Kojima 《Haematologica》2014,99(8):1312-1316
Predicting the response to immunosuppressive therapy could provide useful information to help the clinician define treatment strategies for patients with aplastic anemia. In our current study, we evaluated the relationship between telomere length of lymphocytes at diagnosis and the response to immunosuppressive therapy in 64 children with aplastic anemia, using flow fluorescence in situ hybridization. Median age of patients was ten years (range 1.5–16.2 years). Severity of the disease was classified as very severe in 23, severe in 21, and moderate in 20 patients. All patients were enrolled in multicenter studies using antithymocyte globulin and cyclosporine. The response rate to immunosuppressive therapy at six months was 52% (33 of 64). The probability of 5-year failure-free survival and overall survival were 56% (95% confidence interval (CI): 41–69%) and 97% (95%CI: 87–99%), respectively. Median telomere length in responders was −0.4 standard deviation (SD) (−2.7 to +3.0 SD) and −1.5 SD (−4.0 to +1.6 (SD)) in non-responders (P<0.001). Multivariate analysis showed that telomere length shorter than −1.0 SD (hazard ratio (HR): 22.0; 95%CI: 4.19–115; P<0.001), platelet count at diagnosis less than 25×109/L (HR: 13.9; 95%CI: 2.00–96.1; P=0.008), and interval from diagnosis to immunosuppressive therapy longer than 25 days (HR: 4.81; 95%CI: 1.15–20.1; P=0.031) were the significant variables for poor response to immunosuppressive therapy. Conversely to what has been found in adult patients, measurement of the telomere length of lymphocytes at diagnosis is a promising assay in predicting the response to immunosuppressive therapy in children with aplastic anemia. 相似文献
40.
Kiminori Terui Tsutomu Toki Takashi Taga Shotaro Iwamoto Takako Miyamura Daisuke Hasegawa Hiroshi Moritake Asahito Hama Kentaro Nakashima Rika Kanezaki Ko Kudo Akiko M. Saito Keizo Horibe Souichi Adachi Daisuke Tomizawa Etsuro Ito 《Genes, chromosomes & cancer》2020,59(3):160-167
Myeloid leukemia associated with Down syndrome (ML‐DS) is characterized by a predominance of acute megakaryoblastic leukemia, the presence of GATA1 mutations and a favorable outcome. Because DS children can also develop conventional acute myeloid leukemia with unfavorable outcome, detection of GATA1 mutations is important for diagnosis of ML‐DS. However, myelofibrosis and the significant frequency of dry taps have hampered practical screening of GATA1 mutations using bone marrow (BM) samples. In response to those problems, 82 patients were enrolled in the Japanese Pediatric Leukemia/Lymphoma Study Group AML‐D11 study. GATA1 mutations were analyzed by Sanger sequencing (SS) using genomic DNA (gDNA) from BM and cDNA from peripheral blood (PB) followed by targeted next‐generation sequencing (NGS) using pooled diagnostic samples. BM and PB samples were obtained from 71 (87%) and 82 (100%) patients, respectively. GATA1 mutations were detected in 46 (56%) and 58 (71%) patients by SS using BM gDNA and PB cDNA, respectively. Collectively, GATA1 mutations were identified in 73/82 (89%) patients by SS. Targeted NGS detected GATA1 mutations in 74/82 (90%) patients. Finally, combining the results of SS with those of targeted NGS, GATA1 mutations were identified in 80/82 (98%) patients. These results indicate that SS using BM gDNA and PB cDNA is a rapid and useful method for screening for GATA1 mutations in ML‐DS patients. Thus, a combination of SS and targeted NGS is a sensitive and useful method to evaluate the actual incidence and clinical significance of GATA1 mutations in ML‐DS patients. 相似文献