Katecholaminunabhängige Abnahme des Glykogengehalts im Gehirn bei Vergiftung mit Kohlenmonoxyd

Ohne Zusammenfassung

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Reduction in cerebral glycogen content after carbon monoxide poisoning independent of catecholamines

     

Investigation of the accumulation of fat in the kidneys of mice poisoned with carbon tetrachloride

In mice carbon tetrachloride (3 μ.l/g i.p.) causes an increase in kidney weight, water and triglyceride content after 6h, which is even more pronounced after 12 h. The increase in the renal fat content is closely paralleled by an increase in the serum non-esterified fatty acids. Since both the elevation of the non-esterified fatty acid level in the serum and the increase in the renal triglyceride content can be prevented by the antilipolytic drug ß-pyridylcarbinol (500 μg/g i.m. every 6 h) it is assumed that the accumulation of fat in the kidneys produced by carbon tetrachloride is the result of enhanced lipolysis and uptake of fatty acids into the kidneys, with subsequent esterification of the fatty acids to triglycerides.β-pyridylcarbinol had no influence on the increase in the weight and water content of the kidneys and the morphological changes (albuminous swelling, constriction of the lumen of the tubuli, increased protein permeability) produced in the tubule system by carbon tetrachloride.     

Der Gehalt des Mäusegehirns an Adeninnucleotiden,Kreatinphosphat, Coenzym A und Milchsäure im Excitations-und Toleranzstadium der Narkose

Ohne Zusammenfassung     

Combined toxic effects of tetracycline and ethinyl estradiol on liver function of mice

The combined effects of ethinyl estradiol (EE) (0.5 micrograms/g s.c. once daily for 4 days) and tetracycline (TC) or doxycycline (DC) (50 micrograms/g i.v.) on liver weight and water content, serum transaminases, alkaline phosphatase, urea, triglycerides, and cholesterol as parameters of various liver functions were investigated in mice. It became apparent that depending on the parameter tested synergistic and antagonistic effects may occur, e.g., synergistic effects were observed with the serum transaminases and liver cholesterol; antagonistic effects were seen with the serum urea and serum cholesterol.     

Influence of phenoxybenzamine on methamphetamine-induced changes in locomotor activity, oxygen consumption, body temperature and some metabolic parameters.

The effects of phenoxybenzamine on methamphetamine-induced changes of locomotor activity, oxygen consumption, body temperature and brain glycogen were investigated in mice. Phenoxybenzamine only partly inhibited motor excitation and did not suppress the effects of methamphetamine on the other parameters tested. It appears from these results that phenoxy-benzamine-sensitive α-adrenergic receptors play no decisive role in methamphetamine-induced motor excitation, hypothermia and cerebral glycogenolysis. Since glucose and fatty acid supply was not reduced in phenoxybenzamine + methamphetamine treated animals, any possibly existing antagonism of phenoxybenzamine towards methamphetamine is probably not due to a restricted availability of these substrates.