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排序方式: 共有3648条查询结果,搜索用时 15 毫秒
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Michal Stein Shelly Lipman-Arens Kfir Oved Asi Cohen Ellen Bamberger Roy Navon Olga Boico Tom Friedman Liat Etshtein Meital Paz Tanya M. Gottlieb Or Kriger Yura Fonar Ester Pri-Or Renata Yacobov Yaniv Dotan Amit Hochberg Moti Grupper Adi Klein 《Diagnostic microbiology and infectious disease》2018,90(3):206-213
Bacterial and viral lower respiratory tract infections (LRTIs) are often clinically indistinguishable, leading to antibiotic overuse. We compared the diagnostic accuracy of a new assay that combines 3 host-biomarkers (TRAIL, IP-10, CRP) with parameters in routine use to distinguish bacterial from viral LRTIs. Study cohort included 184 potentially eligible pediatric and adult patients. Reference standard diagnosis was based on adjudication by an expert panel following comprehensive clinical and laboratory investigation (including respiratory PCRs). Experts were blinded to assay results and assay performers were blinded to reference standard outcomes. Evaluated cohort included 88 bacterial and 36 viral patients (23 did not fulfill inclusion criteria; 37 had indeterminate reference standard outcome). Assay distinguished bacterial from viral LRTI patients with sensitivity of 0.93 ± 0.06 and specificity of 0.91 ± 0.09, outperforming routine parameters, including WBC, CRP and chest x-ray signs. These findings support the assay's potential to help clinicians avoid missing bacterial LRTIs or overusing antibiotics. 相似文献
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Andrea Mancuso 《Gastroenterology》2017,152(5):1247-1248
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Tania Pereira Jose Muguruza Virtu Mária Ester Vilaprinyo Albert Sorribas Elvira Fernandez Jose Manuel Fernandez-Armenteros Juan Antonio Baena Ferran Rius Angels Betriu Francesc Solsona Rui Alves 《Ultrasound in medicine & biology》2018,44(12):2780-2792
Adventitial vasa vasorum are physiologic microvessels that nourish artery walls. In the presence of cardiovascular risk factors, these microvessels proliferate abnormally. Studies have reported that they are the first stage of atheromatous disease. Contrast-enhanced ultrasound (CEUS) of the carotid allows direct, quantitative and non-invasive visualization of the adventitial vasa vasorum. Hence, the development of computer-assisted methods that speed image analysis and eliminate user subjectivity is important. We developed methods for automatic analyses and quantification of vasa vasorum neovascularization in CEUS and tested these methods in a cohort of 186 individuals, 63 of whom were healthy volunteers. We implemented alternative automatic strategies for using the images to stratify patients according to their risk group and compare the strategies with respect to diagnostic performance. An automatic single-parameter strategy performs less effectively than the corresponding Arcidiacono method based on manual interpretation of the images (68 < area under the receiver operating characteristic curve [AUROC] for the manual Arcidiacono method < 82; 60 < AUROC for the automatic single-parameter strategy < 63). However, by use of additional image parameters, an automatic multiparameter strategy has significantly improved performance with respect to the manual Arcidiacono method (78 < AUROC < 90). The automatic multiparameter strategy is a valuable alternative to the manual Arcidiacono method, improving both diagnostic speed and diagnostic accuracy. 相似文献
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Recalcitrant granulomatous periorificial dermatitis with good response to low‐dose oral isotretinoin
Nuria Rodriguez‐Garijo Elena Querol‐Cisneros Alejandra Tomas‐Velazquez Angela Estenaga Ester Moreno‐Artero Miguel Angel Idoate Jose Joaquín Paricio Agustin Espaa 《Pediatric dermatology》2019,36(6):980-981
Granulomatous periorificial dermatitis is a clinical variant of periorificial dermatitis. We present the case of an 18‐year‐old girl with several reddish papular lesions in the perioral, perinasal, and periorbital regions unresponsive to conventional therapy. After 6 months of therapy with low‐dose oral isotretinoin, the lesions fully remitted. 相似文献
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