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31.
Vivek Kumbhari Irene Peñas Alan H. Tieu Carlos De la Serna-Higuera Manie Juneja Fuad Maufa Saowanee Ngamruengphong Mohamad H. El-Zein Nadim Haddad Sandeep Krishnan Susana Gonzalez Peter V. Renny Payal Saxena Linda Howard Christopher J. DiMaio Jonathan M. Buscaglia Manuel Perez-Miranda Mouen A. Khashab 《Digestive diseases and sciences》2016,61(12):3552-3559
32.
Wendy A. Woodward Savitri Krishnamurthy Hideko Yamauchi Randa El-Zein Dai Ogura Eri Kitadai Shin-ichiro Niwa Massimo Cristofanilli Peter Vermeulen Luc Dirix Patrice Viens Steve van Laere François Bertucci James M. Reuben Naoto T. Ueno 《Breast cancer research and treatment》2013,138(3):761-772
Inflammatory breast cancer (IBC) is a unique clinical entity characterized by rapid onset of erythema and swelling of the breast often without an obvious breast mass. Many studies have examined and compared gene expression between IBC and non-IBC (nIBC), repeatedly finding clusters associated with receptor subtype, but no consistent gene signature associated with IBC has been validated. Here we compared microdissected IBC tumor cells to microdissected nIBC tumor cells matched based on estrogen and HER-2/neu receptor status. Gene expression analysis and comparative genomic hybridization were performed. An IBC gene set and genomic set were identified using a training set and validated on the remaining data. The IBC gene set was further tested using data from IBC consortium samples and publicly available data. Receptor driven clusters were identified in IBC; however, no IBC-specific gene signature was identified. Fifteen genes were correlated between increased genomic copy number and gene overexpression data. An expression-guided gene set upregulated in the IBC training set clustered the validation set into two clusters independent of receptor subtype but segregated only 75 % of samples in each group into IBC or nIBC. In a larger consortium cohort and in published data, the gene set failed to optimally enrich for IBC samples. However, this gene set had a high negative predictive value for excluding the diagnosis of IBC in publicly available data (100 %). An IBC enriched genomic data set accurately identified 10/16 cases in the validation data set. Even with microdissection, no IBC-specific gene signature distinguishes IBC from nIBC. Using microdissected data, a validated gene set was identified that is associated with IBC tumor cells. Inflammatory breast cancer comparative genomic hybridization data are presented, but a validated genomic data set that identifies IBC is not demonstrated. 相似文献
33.
PURPOSE: To find out if "tubular ectasia of the epididymis" is suggestive of postvasectomy status. METHODS: Tubular ectasia of the epididymis is defined as enlargement of the epididymis with multiple interfaces (i.e., a speckled appearance). We found 24 cases exhibiting tubular ectasia of the epididymis over a period of six years. We reviewed the sonographic findings of tubular ectasia of the epididymis and evaluated the prevalence of associated findings. RESULTS: In 24 patients with tubular ectasia of the epididymis, 16 cases were bilateral, five were right-sided, and three were left-sided. Twenty-one patients had history of vasectomy, of the three remaining cases, 1 had history of inguinal hernia repair, one had prostatitis, and one had undetermined etiology. Associated abnormalities included dilated vas deferens (n = 4), tubular ectasia of the testis (n = 2), large spermatoceles (n = 6), hydrocele (n = 3), and varicocele (n = 4). In 2 cases, spermatic granulomas were suspected. CONCLUSION: Tubular ectasia of the epididymis is suggestive of postvasectomy epididymis. This sonographic feature is helpful in evaluating a patient with scrotal discomfort. However, this sign can also be associated with other causes of vas obstruction. 相似文献
34.
Huang MT; Lou YR; Xie JG; Ma W; Lu YP; Yen P; Zhu BT; Newmark H; Ho CT 《Carcinogenesis》1998,19(9):1697-1700
Female Sencar mice (6 weeks old) were administered 1 mg of 7,12-
dimethylbenz[a]anthracene (DMBA) by oral gavage once a week for 5 weeks. At
20 weeks after the first dose of DMBA, 68% of mice developed mammary tumors
(the average 1.08 tumors per mouse) and 45% had lymphomas/leukemias.
Feeding 1% dibenzoylmethane (DBM) in AIN 76A diet, starting at 2 weeks
before the first dose of DMBA and continuing until the end of the
experiment, inhibited both the multiplicity and incidence of DMBA-induced
mammary tumor by 97%. The incidence of lymphomas/leukemias was completely
inhibited by 1% DBM diet. In contrast, feeding 2% curcumin diet had little
or no effect on the incidence of mammary tumors, and the incidence of
lymphomas/leukemias was reduced by 53%.
相似文献
35.
Albrecht T Deng CZ Abdel-Rahman SZ Fons M Cinciripini P El-Zein RA 《Environmental and molecular mutagenesis》2004,43(3):169-178
We used the mutagen sensitivity assay to test the hypothesis that human cytomegalovirus (HCMV) infection modifies the sensitivity of cells to genetic damage from genotoxic agents. Chromosome aberration (CA) frequency in peripheral blood lymphocytes (PBLs) from 20 smokers who were matched with 20 nonsmokers by age (+/- 5 years), sex, and ethnicity was evaluated following in vitro exposure to bleomycin and/or HCMV infection. Bleomycin induced significant (P < 0.05) concentration-dependent increases in the frequency of aberrant cells, chromatid-type damage (breaks), and chromosome-type aberrations (deletions, rearrangements) in PBLs. The baseline (background) CA frequency was similar in both smokers and nonsmokers. Significantly higher frequencies of aberrant cells (P < 0.05) were observed in PBLs from smokers compared to nonsmokers at all bleomycin concentrations tested (10, 30 and 100 microg/ml). Infection of PBLs with HCMV induced a significant (P < 0.05) twofold increase in the frequency of CA (primarily chromatid breaks) in PBLs, regardless of the smoking status. PBLs from smokers and nonsmokers infected with HCMV prior to challenge with bleomycin demonstrated significant (P < 0.05) concentration-dependent increases in the levels of aberrant cells, chromatid-type damage (breaks), and chromosome-type aberrations (deletions, rearrangements) compared to noninfected cells challenged with bleomycin. The frequency of induced CA was consistently higher for PBLs derived from smokers relative to nonsmokers (P = 0.06 and 0.002). These data indicate that, individually, both smoking and HCMV infection significantly enhance the sensitivity of PBLs to bleomycin-induced genetic damage. More importantly, the data also suggest that smoking and HCMV infection interact synergistically to enhance the sensitivity of PBLs to such damage. 相似文献
36.
37.
El-Zein M Infante-Rivard C Malo JL Gautrin D 《Occupational and environmental medicine》2005,62(10):688-694
Background: The current prospective study investigated the hypothesis of metal fume fever (MFF) being a predictor for the development of respiratory symptoms and functional abnormalities. Methods: The study consisted of a pre-exposure and two follow up assessments of 286 welding apprentices during an average period of 15 months. A respiratory and a systemic symptom questionnaire, skin prick tests to common allergens and metal salts, spirometry, and methacholine challenge tests were administered. Results: Developing at least one positive skin prick test to a metallic salt solution was found in 11.8% of apprentices. Possible MFF (at least one of fever, feelings of flu, general malaise, chills, dry cough, metallic taste, or shortness of breath) was reported by 39.2% of apprentices. The presence of at least one welding related respiratory symptom (cough, wheezing, or chest tightness) suggestive of welding related asthma was reported by 13.8%. MFF was significantly associated with these respiratory symptoms (OR = 4.92, 95% CI 2.10 to 11.52), after adjusting for age, atopy, smoking, physician diagnosed asthma, and symptoms of non-welding related asthma. Apprentices with possible MFF, and no welding related respiratory symptoms suggestive of welding related asthma at the first follow up, had an increased risk of developing the latter symptoms by the second follow up visit (OR = 7.4, 95% CI 1.97 to 27.45) compared with those not having MFF. MFF was not significantly associated with an increase in bronchial responsiveness. Conclusion: MFF could be a predictor for the development of respiratory symptoms but not for functional abnormalities in welders. 相似文献
38.
Nuwayhid IA Usta J Makarem M Khudr A El-Zein A 《Occupational and environmental medicine》2005,62(2):86-94
Aims: To explore associations between work status and multidimensional health indices in a sample of urban Lebanese children. 相似文献
39.
40.
Birjawi GA El-Zein YR Haddad MC 《Le Journal médical libanais. The Lebanese medical journal》2001,49(3):129; author reply 129-129; author reply 130