Antioxidative effects of isoflavon genisteine-8-C-glycoside in vitro and in vivo

Bioflavonoids (polyhydroxyphenols) are ubiquitous components of plants, fruits and vegetables; these compounds are efficient scavengers of free oxygen radicals and peroxides. The aim of this study was to investigate the antioxidative effects of genistein-8-C-glycoside (G8CG) isolated from the flowers of Lipinus luteus L. G8CG dose-dependently inhibited membrane lipid peroxidation and prevented GSH oxidation in human red blood cells and rat liver homogenates under tert-butylhydroperoxide-induced oxidative stress and single whole-body gamma-irradiation (1 Gy) of rats.     

Maintenance of the circulation in vivo by an implanted automatically controlled artificial heart

An artificial heart in which the output is automatically controlled by the venous return, when implanted into dogs in the orthotopic position was found to be highly sensitive to changes in the hemodynamic conditions (a decrease in the venous return, hypo- and hypervolemia, increased peripheral resistance) and prevented the development of critical situations. For 24 h the principal vital functions of the experimental animals were maintained.