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81.
Wei Liu Douglas R. Gnepp Egbert de Vries Haidy Bibawy Marshall Solomon Elizabeth S. Gloster 《Head and neck pathology》2009,3(1):59-62
Sialadenoma papilliferum is a rare tumor, primarily of minor salivary gland origin, first described by Abrams and Finck (Cancer
24:1057–63, 1969). It is both an exophytic and endophytic papillary lesion histologically resembling syringocystadenoma papilliferum of sweat
gland. The tumor is considered benign although rare recurrent cases have been reported. Three cases of malignant transformation
of sialadenoma papilliferum have been described in the literature. We report a high grade mucoepidermoid carcinoma arising
in a background of sialadenoma papilliferum, at the base of the tongue, an unusual location for minor salivary gland neoplasms.
Eleven months after excision and nodal dissection, there is no evidence of recurrence or metastasis. 相似文献
82.
van Werkum JW Seesing TH Suttorp MJ Bal ET den Heijer P Ten Berg JM 《Journal of interventional cardiology》2007,20(2):132-135
We report about three cases with a unique simultaneous double- trouble stent thrombosis in different coronary arteries. Although the triggering mechanism remains purely speculative, it is possible that suboptimal stent size and perhaps underexpansion caused the stent thrombosis in one stent resulting in a heightened platelet activation and impaired hemodynamics causing the second stent thrombosis. 相似文献
83.
Analysis of blood flow and glucose metabolism in mammary carcinomas and normal breast: a H2(15)O PET and 18F-FDG PET study 总被引:2,自引:0,他引:2
Hentschel M Paulus T Mix M Moser E Nitzsche EU Brink I 《Nuclear medicine communications》2007,28(10):789-797
OBJECTIVE: To determine parameters of perfusion, distribution coefficient, and glucose metabolism as part of the tumour-specific micromilieu of breast cancer and compare them with corresponding values in normal breast tissue. METHODS: H2(15)O PET and 18F-FDG PET were performed on 10 patients with advanced invasive ductal carcinomas of the breast. Perfusion, distribution coefficient, and glucose metabolism and standardized uptake were quantified and analysed. RESULTS: Mean values based on the regions of interest were 59.2+/-43.9 ml x min(-1) x 100 g(-1) (perfusion), 0.58+/-0.26 ml x g(-1) (distribution coefficient), 7.76+/-6.10 (standardized uptake), and 5.4+/-2.5 mg x min(-1) x 100 g(-1) (glucose metabolism). The corresponding values for normal breast tissue were 22.1+/-13.2 ml x min x 100 g(-1) (perfusion), 0.16+/-0.05 ml x g(-1) (distribution coefficient), 0.33+/-0.07 (standardized uptake), and 0.18+/-0.08 mg x min x 100 g(-1) (glucose metabolism). For each tumour-normal tissue parameter pair, the mean values were significantly higher in tumours than normal breast tissue. Region-of-interest and pixel-wise correlation analysis revealed a positive association between glucose metabolism and distribution coefficient and glucose metabolism and perfusion for 7/10 tumours investigated. CONCLUSIONS: H2(15)O PET and 18F-FDG PET were able to differentiate breast cancer and normal breast tissue. The pixel-wise analysis revealed information about the heterogeneity of tumour fine structure in perfusion, distribution coefficient, and glucose metabolism, which may provide important guidelines for improving individual treatment. 相似文献
84.
Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study
Kempers MJ Kuiper RP Ockeloen CW Chappuis PO Hutter P Rahner N Schackert HK Steinke V Holinski-Feder E Morak M Kloor M Büttner R Verwiel ET van Krieken JH Nagtegaal ID Goossens M van der Post RS Niessen RC Sijmons RH Kluijt I Hogervorst FB Leter EM Gille JJ Aalfs CM Redeker EJ Hes FJ Tops CM van Nesselrooij BP van Gijn ME Gómez García EB Eccles DM Bunyan DJ Syngal S Stoffel EM Culver JO Palomares MR Graham T Velsher L Papp J Oláh E Chan TL Leung SY van Kessel AG Kiemeney LA Hoogerbrugge N 《The lancet oncology》2011,12(1):49-55
85.
86.
Tanja Johannes Egbert G Mik Karin Klingel Peter T Goedhart Christof Zanke Boris Nohé Hans-Jürgen Dieterich Klaus E Unertl Can Ince 《Clinical and experimental pharmacology & physiology》2009,36(9):870-879
- 1 The pathogenesis of acute renal failure (ARF) in sepsis is multifactorial. The role of nitric oxide (NO) in septic ARF has been a source of controversy. We hypothesized that endotoxaemia‐induced exacerbation of inducible nitric oxide synthase (iNOS)‐related NO release impairs renal oxygenation and contributes to ARF in anaesthetized rats.
- 2 In the present study, rats received lipopolysaccharide (2.5 mg/kg) for 30 min. Two hours later, fluid resuscitation was started (HES130; 5 mL/kg per h after a 5 mL/kg bolus) supplemented either by the NO donor nitroglycerin (NTG; 0.5 µg/kg per min after a 2 µg/kg bolus), the selective iNOS inhibitor 1400W (3 mg/kg per h after a 3 mg/kg bolus) or both. Systemic haemodynamics and renal microvascular Po 2 (µPo 2) were recorded continuously. Furthermore, creatinine clearance, plasma NOx (nitrate + nitrite + S‐nitrosothiols) levels and the expression of iNOS mRNA were measured.
- 3 Endotoxaemia reduced renal blood flow, decreased mean arterial pressure, resulted in anuria and was associated with an increase in plasma NOx levels and renal iNOS expression. Renal µPo 2 deteriorated gradually during endotoxaemia and there was a significant decrease in renal O2 delivery and consumption. Manipulation of NO levels had no beneficial effect on systemic haemodynamics, renal µPo 2 or creatinine clearance over standard fluid resuscitation. The application of 1400W+NTG significantly reduced plasma NOx levels compared with fluid resuscitation and NTG alone.
- 4 Neither iNOS inhibition, NO donation nor a combination of both showed beneficial effects on systemic haemodynamics, renal oxygenation and renal function compared with fluid resuscitation alone. Our results question the proposed key role of NO in the pathogenesis of septic ARF in rats.
87.
Polak WG Peeters PM Miyamoto S Sieders E de Jong KP Porte RJ Bijleveld CM Hendriks HG Tenvergert EM Slooff MJ 《Clinical transplantation》2008,22(2):171-179
Abstract: Between November 1982 and March 2006, 67 children with body weight ≤10 kg had a primary liver transplantation from deceased donors in our unit. The aim of this study was to analyze the outcome in terms of patient and graft survival and to search for factors affecting this outcome. Overall, one-, three-, five-, and 10-yr primary patient and graft survival rates were 73%, 71%, 66%, 63% and 59%, 56%, 53%, 48%, respectively. Twenty-four of 67 (36%) children died and in the remaining 22 (33%), the first grafts failed and they were retransplanted. Cox regression analysis revealed that a need for retransplantation and urgent transplantation were important predictors for patient survival (p = 0.04 and p = 0.001, respectively). To assess whether the need for retransplantation can be influenced, all study variables were compared between surviving grafts and failed grafts. Cox regression analysis showed that only donor/recipient (D/R) weight ratio proved to be independent predictor for graft survival (p = 0.004). After comparison of graft survival with the long rank test according to different D/R weight ratios (3.0–7.0), the cut-off point for significantly different graft survival approached 4.0. The one-, three-, five-, and 10-yr graft survival for technical variant grafts with a D/R weight ratio <4.0 was 85%, 68%, 68%, and 68% compared with a D/R weight ratio >4.0 was 44%, 38%, 38%, and 30%, respectively (p = 0.02). In summary, patient survival in children with body weight ≤10 kg is determined by urgent transplantation and the need for retransplantation. Graft loss and retransplantation in small children can be prevented by adequate size matching of donor and recipient whereby a D/R weight ratio <4.0 seems to offer the favorable outcome. 相似文献
88.
89.
Kim SJ Shin HJ Jung KY Baek SK Shin BK Choi J Kim BS Shin SW Kim YH Kim JS Oosterwijk E 《Japanese journal of clinical oncology》2007,37(11):812-819
BACKGROUND: Hypoxia-induced changes may allow tumor cells to survive under sustained hypoxic microenvironments resulting in achievement of more aggressive phenotypes. The purpose of this study is to determine the prognostic relevance of the expression of carbonic anhydrase IX (CA IX), a hypoxia-related protein in surgically resected squamous cell carcinoma of the tongue. We also relate CA IX to Ki-67 expression representing tumor cell proliferation to provide a prognostic model. METHODS: We analysed the expression of CA IX and Ki-67 with immunohistochemistry in 60 patients with squamous cell carcinoma of the tongue. RESULTS: The percentage of CA IX-positive tumor cells had a wide variation from 0.0 to 77.5%, and the Ki-67 expression was 1.50-75.1%. High CA IX and Ki-67 expression (>/=10.0% of tumor cells positively stained with CA IX and Ki-67) was associated with a poorer overall survival (P < 0.05). High CA IX and Ki-67 expression showed shorter disease-free survival (DFS), although they are not statistically significant. To make a risk model based on the expression of CA IX and Ki-67, we divided the patients into three groups: high risk (high CA IX and Ki-67), low risk (low CA IX and Ki-67) and intermediate risk (either high CA IX or Ki-67). Being in the high-risk group was found to be an independent prognostic factor for overall survival and DFS in multivariate analysis (P < 0.05). CONCLUSION: The expression of CA IX and Ki-67 may be useful for predicting prognosis in squamous cell carcinoma of the tongue. 相似文献
90.
Boosman René J. Jebbink Merel Veldhuis Wouter B. Groenland Stefanie L. van Veggel Bianca A. M. H. Moeskops Pim de Langen Adrianus J. Beijnen Jos H. Smit Egbert F. Huitema Alwin D. R. Steeghs Neeltje 《Pharmaceutical research》2022,39(10):2507-2514
Pharmaceutical Research - Osimertinib, an irreversible inhibitor of the epidermal growth factor receptor (EGFR) is an important drug in the treatment of EGFR-mutation positive non-small cell lung... 相似文献