Hemodynamic Effect of Propafenone and the Experience in Patients with Congestive Heart Failure

The effects of propafenone on left ventricular function and hemodynamics are presented in this study. In one group of 13 patients who underwent electrophysiological testing and subsequent chronic oral therapy with propafenone, eight had left ventricular ejection fractions determined by nuclear study before and during therapy with the drug. Initial measurements ranged from 22% to 39% (mean 30%), while those on chronic therapy showed no statistical difference and ranged from 22% to 48% (mean 30%). In a separate dose titration study of 14 patients, left ventricular ejection fraction showed a modest but significant decrease (52%± 9% to 48%± 11%; p < 0.05). This change was more marked in patients with an initial low ejection fraction. Propafenone appears to be safe in these patients but should be administered with caution in patients with particularly low ejection fractions.     

Corrosive Substance Ingestion in Children

Objectives

To evaluate children who ingested corrosive substances, in terms of demographic features, nature of ingested substances, clinical findings, management and complications.

Methods

A total of 1709 cases aged between 0 and 16 y who ingested corrosive substance were analyzed retrospectively by evaluating the medical records of the patients.

Results

The mean age of the cases was 35.23?±?30.65 mo and male:female ratio was 1.45. Forty one percent of corrosive substances causing intoxication contained NaOH. Thirty percent of the families consisted of 5 or more members. Fourteen percent of the mothers were illiterate. Stricture formation was observed in 29 (1.69 %) of the cases during follow-up. In 79.31 % of those cases alkaline substance ingestion was responsible for stricture development. It was found that stricture formation occurred more frequently among cases who were older than 5 y of age and this finding was statistically significant (p?=?0.001).

Conclusions

The cases older than 5 y of age with the diagnosis of grade 2b esophagitis must be followed up closely for the stricture formation. In order to protect children from corrosive ingestion, importance must be given to preventive measures such as education of families, keeping and storing these agents out of the reach of children and providing safety caps for these products.     

食品药品检验检测信息化建设发展现状与经营介绍——以山东省食品药品检验研究院为例

本文总结了我院2016~2018信息化全面建设工作,包括机房、网络和应用系统建设,重点介绍实验室信息管理系统（LIMS）建设情况、经验和教训,以期为全国食品药品检验检测单位的信息化建设工作提供参考。     

前白蛋白变化率对肝衰竭预后的预测作用

目的探讨血清前白蛋白(PALB)变化率与肝衰竭预后的关系。方法回顾性分析98例肝衰竭患者的临床资料,对患者进行Child-Pugh分级,并把患者分为好转组与未愈组,收集住院期间初始及末次PALB及其他主要肝功能指标的数值,并计算出PALB及其他主要肝功能指标的变化率。结果入院时患者的初始PALB数值明显下降,且Child-Pugh分级越高,数值越低。好转组与未愈组患者的初始PALB数值相近,当血清PALB数值快速升高时,好转组人数明显多于未愈组;当数值下降时,好转组人数明显少于未愈组;当数值升高不明显时,未愈组与好转组差异无统计学意义,但未愈组人数要多于好转组。PALB变化率的敏感度最高,特异度较总胆红素、凝血酶原活动度、国际标准化比值变化率低,而ROC曲线下面积最大。结论肝衰竭患者初始PALB明显比正常值低,而且病情越重,血清中PALB数值越低,但患者预后与初始PALB无相关性,而与PALB变化率相关。大部分PALB快速升高者,预后好;大部分PALB下降或升高缓慢者,预后差。而且PALB变化率对于预后的预测价值要高于其他主要肝功能指标。     

胎儿超声心动图诊断左心发育不良综合征13例报道

目的:探讨应用胎儿超声心动图对左心发育不良综合征(HLHS),诊断方法及诊断价值。方法:对胎儿超声心动图检出的13例HLHS胎儿的超声资料与病理解剖结果对照,分析胎儿超声心动图诊断要点。结果:经病理证实为HLHS 13例,均与超声诊断结果一致,超声诊断正确率100%。13例HLHS患儿中,Ⅰ型2例(15.4%),Ⅱ型5例(38.4%),Ⅲ型2例(15.4%),Ⅳ型4例(30.8%)。超声提示13例均显示左、右心系统比例极端不对称,左心室小、发育不良,右心系统比例增大,主肺动脉内径比例失调,主肺动脉血流方向呈反向。结论:产前胎儿超声心动图作为一种安全、便捷、经济及有效的检查方法,对胎儿左心发育不良综合征的检出具有重要的价值。     

脐带间充质干细胞在遗传性痉挛性截瘫中的应用

目的观察脐带间充质干细胞（UC-MSC）治疗遗传性痉挛性截瘫（HSP）的临床疗效及安全性。方法2010年9月及2011年4月,分别给予一HSP家系父子2人行UC-MSC鞘内注射治疗,两个疗程,每次1×106 cells/Kg,每周1次,4次为1个疗程。采用改良的Ashworth肌张力分级标准（MAS）、国际合作共济失调评分量表（ICARS）及日常生活量表（ADL）,对患者治疗前后神经功能、日常生活能力进行评定。结果第一疗程结束1个月与治疗前比较,2人MAS分级、ICARS及ADL评分均降低,两人行走站立稳定性及言语流利程度较治疗前改善;第二疗程结束后1个月与该疗程治疗前比较,2人ICARS及ADL评分降低,儿子肌张力进一步降低,父亲双上肢共济失调减轻。2人治疗后均未见明显不良反应发生。末次治疗结束后随访20个月,父、子俩分别于第二疗程治疗结束7个月及8个月后,症状继续加重。结论 UC-MSC鞘内注射治疗是安全的,可在一定时间内一定程度上减轻患者临床症状,提高患者生活质量,延缓疾病进展,但疗效不能持久。     

Reliability of four different computerized cephalometric analysis programs

The aim of this investigation was to compare the traditional method of manual cephalometric tracing with four different computerized tracing programs, where the lateral cephalograms were scanned at 300 dpi and digitized onscreen. Thirty randomly selected cephalometric radiographs were used in this study. Four programs Dolphin Imaging, Vistadent, Nemoceph, and Quick Ceph were evaluated. Three dental, 11 skeletal, and 1 soft tissue parameters were measured that consisted of 5 linear and 10 angular measurements. Statistical analysis was carried out using multivariate analysis of variance and Box's and Levene's tests. No statistically significant difference was found between manual tracing and the computerized tracing programs. The measurements obtained with the cephalometric analysis programs used in the study were reliable.     

Ameliorative effect of polydatin on oxidative stress‐mediated testicular damage by chronic arsenic exposure in rats

Arsenic causes lipid peroxidation leading to alterations in antioxidant status in organisms. In this study, the reproductive effects of chronic exposure to arsenic and the protective effects of polydatin (PD) were evaluated in 35 Wistar male rats, which were divided equally into five groups. The control group received a normal diet and tap water, arsenic (100 mg l^?1, approximately 1/50 of oral LD₅₀) was given via drinking water to experimental groups except control group, and PD was orally given to the other groups at dose of 50, 100 and 200 mg kg^?1 for 60 days. Arsenic administration decreased sperm motility, glutathione level, superoxide dismutase and catalase activities in testicular tissue of rats. In contrast, malondialdehyde level and DNA damage were found to be high levels in arsenic‐treated group. Histopathologically, it was observed that decreased sperm concentration and degeneration of Sertoli cells in testicular tissue. PD administration, partially 200 mg kg^?1, reversed arsenic‐induced lipid peroxidation, DNA damage, antioxidant enzyme activity and cell integrity in testis of rats. These results demonstrate that PD decreases arsenic‐induced lipid peroxidation, enhances the antioxidant defence mechanism and regenerates tissue damage in testis of rats.