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141.
To analyze the incidence and risk factors (RF) of nosocomial infection (NI) in a paediatric teaching hospital, a retrospective cohort study was conducted in Salvador, Brazil. The Centres for Disease Control and Prevention definitions were used. The detection of the rotavirus antigen in stool was performed using a rapid latex agglutination test. The study group comprised 2978 admissions that accounted for 32,924 patient-days. The incidence of NI was 8.3/1000 patient-days and 9.2/100 admissions. Of the 274 NI episodes, the most common illness and causative agent were gastroenteritis (125; 45.6%) and rotavirus (59; 21.5%), respectively. The RF for rotavirus NI was young age (10 ± 8 months vs. 27 ± 33 months; mean difference 17 months, 95% CI 15–20 months, p < 0.001). The temporal distribution of community-acquired and NI rotavirus showed similar trends. The universal use of rotavirus vaccine is a potential tool to control NI among children. 相似文献
142.
Arcaini L Paulli M Burcheri S Rossi A Spina M Passamonti F Lucioni M Motta T Canzonieri V Montanari M Bonoldi E Gallamini A Uziel L Crugnola M Ramponi A Montanari F Pascutto C Morra E Lazzarino M;Intergruppo Italiano Linfomi 《British journal of haematology》2007,136(2):301-304
This study defined the clinical features and assessed the prognosis of 47 patients (17 males, 30 females, median age 63 years) with primary nodal marginal zone B-cell lymphoma. Forty-five per cent had stage IV disease. Hepatitis C virus serology was positive in 24%. According to the Follicular Lymphoma International Prognostic Index (FLIPI), 33% were classified as low-risk, 34% as intermediate-risk, and 33% as high-risk. The 5-year overall survival (OS) was 69%. In univariate analysis worse OS was associated with: FLIPI (P = 0.02), age > 60 years (P = 0.05) and raised lactate dehydrogenase (P = 0.05). In multivariate analysis, only FLIPI predicted a worse OS (P = 0.02). 相似文献
143.
Bardelli M Leucci E Schürfeld K Bellan C Passiatore G Rocchigiani M Bartolommei S Orlandini M Zagursky J Lazzi S De Falco G Tosi P Oliviero S Leoncini L 《Leukemia & lymphoma》2007,48(10):2014-2021
Vascular Endothelial Growth Factor (VEGF)-D is a member of the VEGF family of angiogenic growth factors that activate the Vascular Endothelial Growth Factor Receptor (VEGFR)-2 and VEGFR-3, which are mainly expressed in blood and lymphatic vessels. Here we have analyzed by using monoclonal antibodies, the expression of VEGF-D and its cognate receptor VEGFR-3 in normal and pathologic bone marrow and lymph node biopsies. This analysis revealed that VEGF-D is expressed in B cells of the germinal centers, scattered B and T blasts, myeloid progenitors, acute leukemia, several types of non Hodgkin lymphoma, and classical Hodgkin's lymphoma. In normal tissues VEGFR-3 was only expressed in fenestrated capillaries of bone marrow and in lymphatic vessels of lymph nodes, while in VEGF-D expressing tumors newly formed vessels, but not malignant cells, showed high VEGFR-3 expression. These data suggest that VEGF-D could contribute to leukemia and lymphoma growth via the induction of angiogenesis in bone marrow and lymphoid tissues. 相似文献
144.
Marco Metra Marianna Adamo Daniela Tomasoni Alexandre Mebazaa Antoni Bayes-Genis Magdy Abdelhamid Stamatis Adamopoulos Stefan D. Anker Johann Bauersachs Yuri Belenkov Michael Böhm Tuvia Ben Gal Javed Butler Alain Cohen-Solal Gerasimos Filippatos Finn Gustafsson Loreena Hill Tiny Jaarsma Ewa A. Jankowska Mitja Lainscak Yuri Lopatin Lars H. Lund Theresa McDonagh Davor Milicic Brenda Moura Wilfried Mullens Massimo Piepoli Marija Polovina Piotr Ponikowski Amina Rakisheva Arsen Ristic Gianluigi Savarese Petar Seferovic Rajan Sharma Thomas Thum Carlo G. Tocchetti Sophie Van Linthout Cristiana Vitale Stephan Von Haehling Maurizio Volterrani Andrew J.S. Coats Ovidiu Chioncel Giuseppe Rosano 《European journal of heart failure》2023,25(7):1115-1131
Acute heart failure is a major cause of urgent hospitalizations. These are followed by marked increases in death and rehospitalization rates, which then decline exponentially though they remain higher than in patients without a recent hospitalization. Therefore, optimal management of patients with acute heart failure before discharge and in the early post-discharge phase is critical. First, it may prevent rehospitalizations through the early detection and effective treatment of residual or recurrent congestion, the main manifestation of decompensation. Second, initiation at pre-discharge and titration to target doses in the early post-discharge period, of guideline-directed medical therapy may improve both short- and long-term outcomes. Third, in chronic heart failure, medical treatment is often left unchanged, so the acute heart failure hospitalization presents an opportunity for implementation of therapy. The aim of this scientific statement by the Heart Failure Association of the European Society of Cardiology is to summarize recent findings that have implications for clinical management both in the pre-discharge and the early post-discharge phase after a hospitalization for acute heart failure. 相似文献
145.
Governini L Orvieto R Guerranti C Gambera L De Leo V Piomboni P 《Journal of assisted reproduction and genetics》2011,28(5):415-418
In an attempt to assess the effect of perfluorinated compounds (PFC) on oocytes quality and fertilization rate, we studied follicular fluid (FF) PFC levels in 18 patients undergoing IVF-ET cycles. A significant correlation (R = 0.75; P < 0.001) was observed between FF PFC levels and fertilization rate. Moreover, patients with FF PFC contamination had significantly lower fertilization rate (p < 0.02) and number of embryos transferred (p < 0.02), compared to the PFC negative group. 相似文献
146.
Tuveri A Paoletti AM Orrù M Melis GB Marotto MF Zedda P Marrosu F Sogliano C Marra C Biggio G Concas A 《Epilepsia》2008,49(7):1221-1229
Purpose: Seizure exacerbation in catamenial epilepsy (CE) is associated with the decrease in progesterone secretion and increase in estradiol secretion during the premenstrual period. Moreover, experimental evidence suggests that tetrahydrodeoxycorticosterone (THDOC), a positive modulator of the type A receptor for γ-aminobutyric acid (GABA), and dehydroepiandrosterone sulfate (DHEAS), a negative modulator of this receptor, might play a crucial role in modulating seizure frequency during the menstrual cycle. Following these studies it seems of interest to investigate possible variations, among other hormonal parameters, of THDOC and DHEAS in CE patients.
Methods: The serum concentrations of progesterone (P4), pregnenolone, allopregnanolone (AP), THDOC, DHEAS, cortisol, and DHEAS/cortisol ratio were measured throughout the menstrual cycle at the 7th, 11th, 15th, 19th, 23rd, and 27th day from the onset of spontaneous menstrual blood loss in young premenopausal women with CE (n = 17) and age-matched controls (n = 13).
Results: At each time of the study, the serum concentration of THDOC and the DHEAS/cortisol ratio were lower (p < 0.05) in women with CE than in control women. The concentrations of P4, pregnenolone, and AP did not differ between the two groups of subjects.
Conclusions: The reduced serum concentration of THDOC and the reduced DHEAS/cortisol ratio detected throughout the menstrual cycle in women with CE might play a role in CE. Moreover, the peculiar pattern of CE seizure exacerbation might suggest that these neuroendocrine variations are worth investigating in other epileptic syndromes, particularly in those characterized by relevant and uncontrolled variations in seizure frequency. 相似文献
Methods: The serum concentrations of progesterone (P4), pregnenolone, allopregnanolone (AP), THDOC, DHEAS, cortisol, and DHEAS/cortisol ratio were measured throughout the menstrual cycle at the 7th, 11th, 15th, 19th, 23rd, and 27th day from the onset of spontaneous menstrual blood loss in young premenopausal women with CE (n = 17) and age-matched controls (n = 13).
Results: At each time of the study, the serum concentration of THDOC and the DHEAS/cortisol ratio were lower (p < 0.05) in women with CE than in control women. The concentrations of P4, pregnenolone, and AP did not differ between the two groups of subjects.
Conclusions: The reduced serum concentration of THDOC and the reduced DHEAS/cortisol ratio detected throughout the menstrual cycle in women with CE might play a role in CE. Moreover, the peculiar pattern of CE seizure exacerbation might suggest that these neuroendocrine variations are worth investigating in other epileptic syndromes, particularly in those characterized by relevant and uncontrolled variations in seizure frequency. 相似文献
147.
148.
Micheli F Bonanomi G Blaney FE Braggio S Capelli AM Checchia A Curcuruto O Damiani F Fabio RD Donati D Gentile G Gribble A Hamprecht D Tedesco G Terreni S Tarsi L Lightfoot A Stemp G Macdonald G Smith A Pecoraro M Petrone M Perini O Piner J Rossi T Worby A Pilla M Valerio E Griffante C Mugnaini M Wood M Scott C Andreoli M Lacroix L Schwarz A Gozzi A Bifone A Ashby CR Hagan JJ Heidbreder C 《Journal of medicinal chemistry》2007,50(21):5076-5089
The discovery of new highly potent and selective dopamine D3 receptor antagonists has recently permitted characterization of the role of the dopamine D3 receptor in a wide range of preclinical animal models. A novel series of 1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines demonstrating a high level of D3 affinity and selectivity with an excellent pharmacokinetic profile is reported here. In particular, the pyrazolyl derivative 35 showed good oral bioavailability and brain penetration associated with high potency and selectivity in vitro. In vivo characterization of 35 confirmed that this compound blocks the expression of nicotine- and cocaine-conditioned place preference in the rat, prevents nicotine-triggered reinstatement of nicotine-seeking behavior in the rat, reduces oral operant alcohol self-administration in the mouse, increases extracellular levels of acetylcholine in the rat medial prefrontal cortex, and potentiates the amplitude of the relative cerebral blood volume response to d-amphetamine in a regionally specific manner in the rat brain. 相似文献
149.
Local recurrence and local control of non-metastatic osteosarcoma of the extremities: a 27-year experience in a single institution 总被引:3,自引:0,他引:3
Bacci G Forni C Longhi A Ferrari S Mercuri M Bertoni F Serra M Briccoli A Balladelli A Picci P 《Journal of surgical oncology》2007,96(2):118-123
BACKGROUND: Indications and contraindications for limb salvage versus amputation for local treatment of osteosarcoma of the extremity are still controversial. PATIENTS AND METHODS: Patients (1,126) with non-metastatic osteosarcoma of the extremity, treated in a single institution between 1972 and 1999 with different protocols of adjuvant and neoadjuvant chemotherapy were evaluated to establish factors that could influence local recurrence (LR) and outcome. RESULTS: The 5-year event-free survival and overall survival were 55% and 66%. At a follow-up ranging between 5.5 and 32.5 years (mean18.6 years) of the 1,126 evaluated patients, 607 (54%) remained continuously disease-free and 519 relapsed. LR developed in 61 patients (5.4%) after a median time of 2.3 years (0.2-17). For this group of patients the 5-year post-relapse event-free survival and overall survival from the last relapse were, respectively, 11.4% and 16.4%. At the multivariate analyses only surgical margins and histologic response to preoperative treatment resulted to be independent prognostic factors for LR. CONCLUSION: Considering the risk of LR after surgery with inadequate surgical margins and poor prognosis of LR in osteosarcoma, limb salvage procedures should be performed only when adequate margins surgical margins can be achieved. In case of inadequate margins, an immediate amputation should be considered. 相似文献
150.
Cristiana Pereira Mário Bernardo Dinis Pestana Jorge Costa Santos Maria Cristina de Mendonça 《Journal of Forensic and Legal Medicine》2010,17(2):105-110
We investigate the accuracy of odontometric methods in sex determination, using a sample from the Portuguese population. Measurements were made on dental casts using a digital caliper, and various odontometric indexes have been defined using upper incisor and canine teeth.Comparison of the means in both sexes was performed using Student’s t-test. Significant differences (p < 0.05) were found in all variables except for the “Incisor Index”. The canine showed the greatest sexual discriminant characteristics. In the presence of one or both canines the distobuccal–mesiolingual crown diameter and the “Robustness Value” allowed discrimination between sexes in the studied population. We also provide further arguments on the debate on whether sex determination is population specific. 相似文献