全文获取类型
收费全文 | 2113篇 |
免费 | 128篇 |
国内免费 | 113篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 139篇 |
妇产科学 | 52篇 |
基础医学 | 243篇 |
口腔科学 | 37篇 |
临床医学 | 205篇 |
内科学 | 547篇 |
皮肤病学 | 57篇 |
神经病学 | 97篇 |
特种医学 | 394篇 |
外国民族医学 | 1篇 |
外科学 | 126篇 |
综合类 | 48篇 |
预防医学 | 141篇 |
眼科学 | 49篇 |
药学 | 112篇 |
中国医学 | 2篇 |
肿瘤学 | 96篇 |
出版年
2022年 | 14篇 |
2021年 | 27篇 |
2020年 | 22篇 |
2019年 | 28篇 |
2018年 | 43篇 |
2017年 | 18篇 |
2016年 | 42篇 |
2015年 | 41篇 |
2014年 | 42篇 |
2013年 | 70篇 |
2012年 | 72篇 |
2011年 | 97篇 |
2010年 | 80篇 |
2009年 | 73篇 |
2008年 | 55篇 |
2007年 | 94篇 |
2006年 | 60篇 |
2005年 | 82篇 |
2004年 | 42篇 |
2003年 | 48篇 |
2002年 | 31篇 |
2001年 | 46篇 |
2000年 | 48篇 |
1999年 | 42篇 |
1998年 | 100篇 |
1997年 | 99篇 |
1996年 | 110篇 |
1995年 | 68篇 |
1994年 | 65篇 |
1993年 | 68篇 |
1992年 | 25篇 |
1991年 | 43篇 |
1990年 | 34篇 |
1989年 | 59篇 |
1988年 | 47篇 |
1987年 | 56篇 |
1986年 | 39篇 |
1985年 | 55篇 |
1984年 | 27篇 |
1983年 | 24篇 |
1982年 | 28篇 |
1981年 | 21篇 |
1980年 | 32篇 |
1979年 | 16篇 |
1978年 | 17篇 |
1977年 | 18篇 |
1976年 | 28篇 |
1975年 | 17篇 |
1974年 | 9篇 |
1970年 | 7篇 |
排序方式: 共有2354条查询结果,搜索用时 982 毫秒
111.
Optimal pharmacological treatment and adherence to medication in secondary prevention of cardiovascular events in Spain: Results from the CAPS study
下载免费PDF全文
![点击此处可从《Cardiovascular therapeutics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
112.
K Nandar LW Ang J Tey L James KM Kyi Win CBE Chee OT Ng JL Cutter YT Wang 《HIV medicine》2018,19(1):59-64
Cross‐matching of records between Singapore's tuberculosis and HIV registries showed that 3.3% of individuals with tuberculosis (TB) were coinfected with HIV (2000?2014), the TB incidence among individuals with HIV infection was 1.65 per 100 person‐years, and 53% of coinfections were diagnosed within 1 month of each other. The findings supported joint prevention programmes for early diagnosis and treatment. 相似文献
113.
AMP-18,一种新发现的胃黏膜保护因子 总被引:3,自引:0,他引:3
AMP-18是一种新发现的由胃腺体上皮细胞合成的小分子蛋白质,独特表达于胃黏膜,机体其他部位少见,胃癌组织中表达缺失.AMP-18 由185个氨基酸组成,除去N端信号肽(20个氨基酸)后大小约18 ku,第54-150个氨基酸组成高度保守的结构域(BRICHOS区域)承担主要的生理功能.AMP-18由胃腺体上皮细胞以胞吐的方式分泌到胃黏液中,他的合成和分泌与个体生长发育有关,并受福斯高林、吲哚美辛、地塞米松等药物的影响.目前发现 AMP-18的生理功能主要有促进胃黏膜上皮细胞的有丝分裂,促进细胞的迁徙,促胃肠黏膜损伤的修复,保持胃肠黏膜的完整等. 相似文献
114.
Velázquez-Pérez Luis Medrano-Montero Jacqueline Rodríguez-Labrada Roberto Canales-Ochoa Nalia Campins Alí Jandy Carrillo Rodes Frank J Rodríguez Graña Tania Hernández Oliver María O. Aguilera Rodríguez Raul Domínguez Barrios Yennis Torres Vega Reydenis Flores Angulo Lissi Cordero Navarro Noharis Y. Sigler Villanueva Aldo A. Gámez Rodríguez Osiel Sagaró Zambrano Ilya Navas Napóles Nayime Y. García Zacarías Javier Serrano Barrera Orlando R. Ramírez Bautista María B. Estupiñán Rodríguez Annelié Guerra Rondón Leonardo A. Vázquez-Mojena Yaimeé González-Zaldivar Yanetza Almaguer Mederos Luis E. Leyva-Mérida Alejandro 《Cerebellum (London, England)》2020,19(2):252-264
The Cerebellum - The prevalence estimations of hereditary ataxias are biased since most epidemiological studies are confined to isolated geographical regions and few nationwide studies are... 相似文献
115.
Silvia Cmara M Concepcin Fournier Patricia Cordero Javier Melero Fernando Robles Borja Esteso M Teresa Vara Serafn Rodrguez lvaro Lassaletta Marcelo Budke 《Cerebellum (London, England)》2020,19(1):78-88
Cerebellar mutism syndrome (CMS) is a common surgical sequela in children following posterior fossa tumor (PFT) resection. Here, we analyze the neuropsychological features associated with PFT in children, focusing particularly on the differential profiles associated with the presence or absence of CMS after surgery. We further examine the effect of post-resection treatments, tumor type, and presence/absence of hydrocephalus on surgical outcome. Thirty-six patients diagnosed with PFT (19 with and 17 without CMS) and 34 age- and gender-matched healthy controls (HCs) were recruited. A comprehensive neuropsychological evaluation was conducted in all patients postoperatively and in HCs, including an assessment of general cognitive ability, motor skills, perception, language, memory, attention, executive functions, and academic competence. CMS was found to be a clinical marker of lower neuropsychological profile scores across all cognitive domains except auditory-verbal processing and visual memory tasks. PFT patients not presenting CMS exhibited milder impairment in intellectual functioning, motor tasks, reasoning, language, verbal learning and recall, attention, cognitive executive functions, and academic competence. High-grade tumors were associated with slower processing speed and verbal delayed recall as well as alterations in selective and sustained attention. Hydrocephalus was detrimental to motor functioning and nonverbal reasoning. Patients who had undergone surgery, chemotherapy, and radiotherapy presented impaired processing speed, verbal learning, and reading. In addition to the deleterious effects of PFT, post-resection PFT treatments have a negative cognitive impact. These undesired consequences and the associated tumor-related damage can be assessed using standardized, long-term neuropsychological evaluation when planning rehabilitation. 相似文献
116.
117.
BACKGROUND: HIV-1 infection has been associated with high expression of CD38 on peripheral blood (PB) CD8+ and CD4+ T-cells, which has been related with poor prognosis in untreated HIV-1+ patients. In turn, CD38 expression on PB monocytes from HIV-1+ individuals and its behavior after starting antiretroviral therapy (ART) have been poorly studied. METHODS: CD38 expression on PB CD8+ and CD4+ T-lymphocytes and monocytes was prospectively analyzed in 30 ART-naive HIV-1+ patients, using a quantitative multiparameter flow cytometry approach. Patients were tested prior to therapy, and at weeks +2, +4, +8, +12, and +52 after ART. RESULTS: Prior to ART, CD38 expression was significantly increased on PB CD8+ and CD4+ T-cells and monocytes; despite a significant decrease after ART, CD38 expression remained abnormally high on PB CD8+ T-cells and monocytes, even after one year of therapy, in the absence of detectable plasma viral load. The ART-induced early changes on CD38 expression by PB T-cells and monocytes differed among the cell subsets analyzed and patient groups, probably reflecting an interaction between the direct effects of therapy and a redistribution of the PB compartments of T-cells and monocytes. Hierarchical clustering analysis showed that the overall pattern of changes in CD38 expression observed early after starting ART was predictive of a better response to therapy, not only for PB CD8+ T-cells, but also for CD4+ T-cells and monocytes. Accordingly, those HIV-1+ patients, who experienced a more pronounced increase in CD38 expression on both PB CD4+ T-cells and monocytes after 2 weeks of ART, showed a more rapid viral clearance, which might reflect decreased HIV-1 replication in lymph nodes and other tissues, and a partial restoration of hematopoiesis. CONCLUSIONS: Combined quantitative measurement of CD38 expression on PB monocytes, and CD8+ and CD4+ T-cells is a more useful tool for monitoring HIV-1+ patients under ART, rather than quantitation of CD38 expression on PB CD8+ T-lymphocytes alone. 相似文献
118.
119.
120.
P Valenzuela MS Saiz Puente JL Valero R Azorín R Ortega R Guijarro 《BJOG : an international journal of obstetrics and gynaecology》2009,116(3):436-441
Objective To evaluate the repair techniques of continuous and interrupted methods for episiotomy or perineal tears.
Design A randomised controlled trial.
Setting The Hospital Universitario Principe de Asturias, a state hospital belonging to the community of Madrid.
Sample Four hundred forty-five women who had undergone vaginal deliveries with episiotomies or second-grade tearing of the perineum between September 2005 and July 2007.
Methods One group was repaired with continuous, nonlocking sutures involving the vagina, perineum, and subcutaneous tissues. The other group had continuous, locking sutures of the vagina, interrupted sutures in the perineal muscles, and interrupted transcutaneous sutures. The threads used for stitching were identical in both groups.
Main outcome measures The participants were questioned regarding the sensation of pain and the use of painkillers on the second and the tenth days, and 3 months postpartum.
Results When comparing the group with continuous suture to the group with interrupted sutures, the differences included less repair time (1 minute; P = 0.017) and less suture material used (relative risk [RR], 3.2, 95% CI: 2.6–4.0). The comparison of pain on the second and tenth days, and 3 months postpartum were not statistically different between the two techniques (RR, 1.08, 95% CI: 0.74–1.57; RR, 0.96, 95% CI: 0.59–1.55; and RR, 0.68, 95% CI: 0.19–2.46, respectively).
Conclusions Although we did not demonstrate that one technique was better than the other in the incidence of pain in the short or long term, we showed that episiotomy and perineal tear repairs with continuous suturing were quicker and used less suture material without an increase in complication than interrupted suturing. 相似文献
Design A randomised controlled trial.
Setting The Hospital Universitario Principe de Asturias, a state hospital belonging to the community of Madrid.
Sample Four hundred forty-five women who had undergone vaginal deliveries with episiotomies or second-grade tearing of the perineum between September 2005 and July 2007.
Methods One group was repaired with continuous, nonlocking sutures involving the vagina, perineum, and subcutaneous tissues. The other group had continuous, locking sutures of the vagina, interrupted sutures in the perineal muscles, and interrupted transcutaneous sutures. The threads used for stitching were identical in both groups.
Main outcome measures The participants were questioned regarding the sensation of pain and the use of painkillers on the second and the tenth days, and 3 months postpartum.
Results When comparing the group with continuous suture to the group with interrupted sutures, the differences included less repair time (1 minute; P = 0.017) and less suture material used (relative risk [RR], 3.2, 95% CI: 2.6–4.0). The comparison of pain on the second and tenth days, and 3 months postpartum were not statistically different between the two techniques (RR, 1.08, 95% CI: 0.74–1.57; RR, 0.96, 95% CI: 0.59–1.55; and RR, 0.68, 95% CI: 0.19–2.46, respectively).
Conclusions Although we did not demonstrate that one technique was better than the other in the incidence of pain in the short or long term, we showed that episiotomy and perineal tear repairs with continuous suturing were quicker and used less suture material without an increase in complication than interrupted suturing. 相似文献