全文获取类型
收费全文 | 1692篇 |
免费 | 123篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 213篇 |
妇产科学 | 43篇 |
基础医学 | 188篇 |
口腔科学 | 7篇 |
临床医学 | 116篇 |
内科学 | 280篇 |
皮肤病学 | 19篇 |
神经病学 | 223篇 |
特种医学 | 63篇 |
外科学 | 188篇 |
综合类 | 75篇 |
预防医学 | 98篇 |
眼科学 | 42篇 |
药学 | 115篇 |
中国医学 | 24篇 |
肿瘤学 | 107篇 |
出版年
2022年 | 19篇 |
2021年 | 29篇 |
2020年 | 14篇 |
2019年 | 20篇 |
2018年 | 28篇 |
2017年 | 19篇 |
2016年 | 29篇 |
2015年 | 28篇 |
2014年 | 33篇 |
2013年 | 62篇 |
2012年 | 72篇 |
2011年 | 58篇 |
2010年 | 41篇 |
2009年 | 30篇 |
2008年 | 68篇 |
2007年 | 74篇 |
2006年 | 71篇 |
2005年 | 66篇 |
2004年 | 67篇 |
2003年 | 44篇 |
2002年 | 59篇 |
2001年 | 52篇 |
2000年 | 50篇 |
1999年 | 43篇 |
1997年 | 14篇 |
1996年 | 13篇 |
1992年 | 41篇 |
1991年 | 36篇 |
1990年 | 34篇 |
1989年 | 23篇 |
1988年 | 32篇 |
1987年 | 15篇 |
1986年 | 28篇 |
1985年 | 14篇 |
1984年 | 15篇 |
1983年 | 15篇 |
1979年 | 13篇 |
1975年 | 18篇 |
1974年 | 20篇 |
1973年 | 27篇 |
1972年 | 16篇 |
1971年 | 12篇 |
1970年 | 18篇 |
1966年 | 14篇 |
1962年 | 12篇 |
1959年 | 13篇 |
1958年 | 14篇 |
1955年 | 13篇 |
1948年 | 12篇 |
1947年 | 15篇 |
排序方式: 共有1815条查询结果,搜索用时 0 毫秒
1.
The methanolic fraction of P. indica root extract was found to possess significant antiulcer activity in different experimental animal models. In preventive antiulcer tests, significant protective actions in acetylsalicylic acid, serotonin and indomethacin-induced gastric lesions were observed in experimental rats. The extract also afforded significant protection to chemically-induced duodenal lesion in guineapigs. Significant enhancement of healing process in acetic acid-induced chronic gastric lesions were also observed in the extract-treated animals. 相似文献
2.
A number of investigators have suggested treatment of precursor lesions for invasive breast cancer such as ductal carcinoma in situ with antiestrogen. However, very little information is available on the incidence of estrogen receptor in such lesions and the probability of treatment success. Fourteen formalin-fixed tissue specimens of intraductal carcinoma in situ from 14 female patients aged 40 to 66 years were evaluated for the presence of estrogen receptor by immunoperoxidase technique using estrogen receptor antibody. Eight of the 14 lesions (57%) were positive for estrogen receptor. The incidence of estrogen receptor in intraductal carcinoma in situ is very similar to that of invasive carcinoma of breast, leading to the speculation that ER-positive invasive carcinoma originates from ER-positive precursor lesions. Since only 70 per cent of positive receptor lesions are expected to respond to antiestrogens, it appears that only 40 per cent of patients with ductal carcinoma in situ of breast will benefit from endocrine therapy. 相似文献
3.
4.
A Misbahuddin M R Placzek K R Chaudhuri N W Wood K P Bhatia T T Warner 《Neurology》2002,58(1):124-126
Abnormalities in dopamine neurotransmission are thought to underlie the generation of dystonic movements. The authors performed a case-control allelic association study in patients with the focal dystonia blepharospasm, using polymorphisms in the dopamine receptor and transporter genes. Allele 2 of a DRD5 dinucleotide repeat was significantly associated with blepharospasm. This may indicate a pathogenic role for this receptor. 相似文献
5.
Kallol Ray Chaudhuri Pablo Martinez-Martin Anthony H V Schapira Fabrizio Stocchi Kapil Sethi Per Odin Richard G Brown William Koller Paolo Barone Graeme MacPhee Linda Kelly Martin Rabey Doug MacMahon Sue Thomas William Ondo David Rye Alison Forbes Susanne Tluk Vandana Dhawan Annette Bowron Adrian J Williams Charles W Olanow 《Movement disorders》2006,21(7):916-923
Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD NMS, median = 9.0, mean = 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals. 相似文献
6.
7.
8.
Shyamal K Das Tapas K Banerjee Atanu Biswas Trishit Roy Deepak K Raut Arijit Chaudhuri Abhijit Hazra 《Movement disorders》2007,22(14):2031-2036
An epidemiological study on dystonia has not been reported from India. As part of a major study to find out the prevalence of major neurological disorders in the large urban city of Kolkata, Eastern India, we planned to determine the prevalence of primary dystonia. The study design was a cross-sectional study of a sample population obtained through stratified random selection and conducted in a two-stage procedure of screening by a nonprofessional team followed by confirmation of screened positive cases by the study neurologist. A total population of 52,377 was screened, and 29 subjects with dystonia were diagnosed. Out of them 23 subjects had primary dystonias [crude prevalence rate (CPR), 43.91/100,000; 95% confidence interval (CI), 28.41-64.81; age-standardized rates to world standard population, 49.06 (95% CI,31.74-72.41)] and all cases were focal type and predominantly of limb dystonia variety. Mean onset of dystonias were earlier in women (43.5 years) as compared to men (46.6 years). Thus our study on primary dystonia shows higher prevalence when compared with that of many studies globally, predominantly of focal type, earlier onset among women, and more cases of limb dystonias when compared with more prominent blepharospasm and cervical dystonias in western reports. 相似文献
9.
A case of Waterhouse-Friderichsen syndrome associated with septicaemia caused by a DF-2 group bacterium (dysgonic fermenter--type 2--Atlanta classification) is presented. Attention is drawn to the relation of DF-2 group septicaemias to dog bites (or contact) and impaired host defence after splenectomy. 相似文献
10.
Conventional indirect haemagglutination test was performed in rhesus monkey sera (collected from Plasmodium knowlesi infected animals) with and without prior treatment of sera with 2-mercapto-ethanol (2-ME). Surprisingly, many sera samples showed significant enhancement of final titre with 2-ME. The 2-ME enhancement effect was more pronounced in the sera of hyperimmune monkeys on further injection of antigen or parasites. It was also noticeable in the sera during primary drug-suppressed P. knowlesi infection and appeared to have a bearing on the immune status of the animals to rechallenge. The use of a soluble antigen prepared from P. knowlesi infected erythrocytes was found to be essential in IHA test to demonstrate the 2-ME enhancement effect. Antigen prepared from freed parasites (commonly used) failed to show a similar effect in IHA. The possible role of certain T-lymphocyte products - antigen binding, non-agglutinating, 2-ME sensitive molecules - in malarial immunology has been proposed. 相似文献