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Wayne L. Monsky Armando S. Garza Isaac Kim Shaun Loh Tzu-Chun Lin Chin-Shang Li Jerron Fisher Parmbir Sandhu Vishal Sidhar Abhijit J. Chaudhari Frank Lin Larry-Stuart Deutsch Ramsey D. Badawi 《Cardiovascular and interventional radiology》2011,34(2):306-318
Purpose
The primary purpose of this study was to demonstrate intraobserver/interobserver reproducibility for novel semiautomated measurements of hepatic volume used for Yttrium-90 dose calculations as well as whole-liver and necrotic-liver (hypodense/nonenhancing) tumor volume after radioembolization. The secondary aim was to provide initial comparisons of tumor volumetric measurements with linear measurements, as defined by Response Evaluation Criteria in Solid Tumors criteria, and survival outcomes.Methods
Between 2006 and 2009, 23 consecutive radioembolization procedures were performed for 14 cases of hepatocellular carcinoma and 9 cases of hepatic metastases. Baseline and follow-up computed tomography obtained 1?month after treatment were retrospectively analyzed. Three observers measured liver, whole-tumor, and tumor-necrosis volumes twice using semiautomated software.Results
Good intraobserver/interobserver reproducibility was demonstrated (intraclass correlation [ICC]?>?0.9) for tumor and liver volumes. Semiautomated measurements of liver volumes were statistically similar to those obtained with manual tracing (ICC?=?0.868), but they required significantly less time to perform (p?<?0.0001, ICC?=?0.088). There was a positive association between change in linear tumor measurements and whole-tumor volume (p?<?0.0001). However, linear measurements did not correlate with volume of necrosis (p?>?0.05). Dose, change in tumor diameters, tumor volume, and necrotic volume did not correlate with survival (p?>?0.05 in all instances). However, Kaplan?CMeier curves suggest that a >10% increase in necrotic volume correlated with survival (p?=?0.0472).Conclusion
Semiautomated volumetric analysis of liver, whole-tumor, and tumor-necrosis volume can be performed with good intraobserver/interobserver reproducibility. In this small retrospective study, measurements of tumor necrosis were suggested to correlate with survival. 相似文献84.
We evaluated a recently developed live fowl typhoid (FT) vaccine candidate, JOL916, the cpxR/lon mutant of Salmonella Gallinarum (SG), for safety and protection efficacy in 5-week-old layer chickens. Intramuscular vaccination with JOL916 revealed no or very few lesions in livers and spleens of the animals until the fourth week post-vaccination (wpv). This candidate clearly induced cellular immune responses in 5 of 5 chickens on the first and second wpv based on the peripheral lymphocyte proliferation assay. Systemic IgG responses were observed in 5 of 5 chickens from the first wpv and dramatic elevations were observed on the second and third wpv. Vaccination of chickens offered efficient protection against challenge by a wild-type SG; only slight anorexia and depression were temporarily observed after challenge in the vaccinated group while 100% mortality was observed in the positive control group. Body weight increases per day were slightly reduced between the 3rd and 6th day post challenge (dpc) compared to the negative control group; it was recovered from the 6th dpc. Collectively, these results demonstrate the safety and protective efficacy of JOL916 as a live vaccine for systemic FT. 相似文献
85.
Ruani N. Fernando Umesh Chaudhari Sylvia E. Escher Jan G. Hengstler Jürgen Hescheler Paul Jennings Hector C. Keun Jos C. S. Kleinjans Raivo Kolde Laxmikanth Kollipara Annette Kopp-Schneider Alice Limonciel Harshal Nemade Filomain Nguemo Hedi Peterson Pilar Prieto Robim M. Rodrigues Agapios Sachinidis Christoph Schäfer Albert Sickmann Dimitry Spitkovsky Regina Stöber Simone G. J. van Breda Bob van de Water Manon Vivier René P. Zahedi Mathieu Vinken Vera Rogiers 《Archives of toxicology》2016,90(6):1529-1539
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Mishra V Mishra M Ansari KM Chaudhari BP Khanna R Das M 《European journal of cancer (Oxford, England : 1990)》2012,48(13):2075-2085
Carcinogenic potential of argemone oil (AO) and butter yellow (BY), the adulterants encountered in edible oil, in gall bladder of Swiss albino mice was undertaken to investigate the potential aetiological factors of gall bladder carcinoma (GBC) in the Indo-Gangetic basin. Twice weekly intraperitoneal (ip) administration of AO (5 ml/kg body wt) and BY (25 mg/kg body wt) to Swiss albino male and female mice for 30 and 60 days indicated that females were more vulnerable to these adulterants in terms of responses to inflammatory markers. Subsequent experiments with dietary exposure of AO (1%) and BY (0.06%) for 6 months in female mice showed symptoms related to cachexia, jaundice and anaemia. High levels of total cholesterol, low density lipoprotein (LDL), TG, bilirubin and low level of high density lipoprotein (HDL) as well as gallstone formation was shown by AO exposure only, leading to the development of adenocarcinoma. BY exposure resulted in adenoma and hyperplasia without stone formation. The cyclooxygenase (COX-2) overexpression was found to be related to prostaglandin E2 (PGE2) production in AO treated mice but not in BY exposed animals, thereby indicating a differential pathway specific carcinogenicity. PGE2 stimulates the secretion of secreted mucins (MUC5AC), which is involved in stone formation following AO exposure. Enhanced secretion of membrane bound mucins (MUC4) in BY and AO exposed mice resulted in the activation of ErbB2 and downstream signalling such as p-AKT, p-ERK and p-JNK, which ultimately affects the target proteins, p53 and p21 leading to adenoma and adenocarcinoma, respectively. The study suggests that AO and BY are responsible for producing GBC in mice along with stone formation in the AO exposed animals. 相似文献
89.
Tejasvi Chaudhari Meiri Robertson David Ellwood Erroll Simpson Zsuzsoka Kecskes Alison L Kent 《Journal of paediatrics and child health》2013,49(1):E97-E100
Urinary ascites in a newborn infant is unusual and most commonly results from bladder perforation following umbilical arterial catheterisation or obstructive uropathy. The following report describes a case of fetal bladder rupture with urinary ascites in a mother ventilated and sedated with narcotics and benzodiazepines for H1N1 influenza. This was associated with a unique biochemical profile of hyponatraemia and elevated serum urea and creatinine characteristic of urinary autodialysis in the neonate. 相似文献
90.
Sudha Chaudhari Madhumati Otiv Bharati Khairnar Anand Pandit Mahendra Hoge Mehmood Sayyad 《Indian pediatrics》2013,50(9):853-857