全文获取类型
收费全文 | 3591692篇 |
免费 | 300307篇 |
国内免费 | 14297篇 |
专业分类
耳鼻咽喉 | 48613篇 |
儿科学 | 114116篇 |
妇产科学 | 93230篇 |
基础医学 | 569571篇 |
口腔科学 | 95213篇 |
临床医学 | 323961篇 |
内科学 | 642147篇 |
皮肤病学 | 94328篇 |
神经病学 | 310510篇 |
特种医学 | 140213篇 |
外国民族医学 | 493篇 |
外科学 | 549452篇 |
综合类 | 108401篇 |
现状与发展 | 24篇 |
一般理论 | 2392篇 |
预防医学 | 302253篇 |
眼科学 | 81754篇 |
药学 | 246061篇 |
22篇 | |
中国医学 | 10544篇 |
肿瘤学 | 172998篇 |
出版年
2021年 | 56019篇 |
2020年 | 35689篇 |
2019年 | 58858篇 |
2018年 | 72658篇 |
2017年 | 55504篇 |
2016年 | 61488篇 |
2015年 | 75306篇 |
2014年 | 109773篇 |
2013年 | 175253篇 |
2012年 | 103688篇 |
2011年 | 104473篇 |
2010年 | 119806篇 |
2009年 | 123881篇 |
2008年 | 90853篇 |
2007年 | 95018篇 |
2006年 | 104983篇 |
2005年 | 100134篇 |
2004年 | 101321篇 |
2003年 | 91382篇 |
2002年 | 80826篇 |
2001年 | 119063篇 |
2000年 | 112568篇 |
1999年 | 108325篇 |
1998年 | 67115篇 |
1997年 | 64584篇 |
1996年 | 62334篇 |
1995年 | 57794篇 |
1994年 | 51679篇 |
1993年 | 48228篇 |
1992年 | 74801篇 |
1991年 | 70461篇 |
1990年 | 66127篇 |
1989年 | 64911篇 |
1988年 | 59825篇 |
1987年 | 58506篇 |
1986年 | 55054篇 |
1985年 | 54844篇 |
1984年 | 49802篇 |
1983年 | 45326篇 |
1982年 | 42328篇 |
1981年 | 39668篇 |
1980年 | 37345篇 |
1979年 | 40471篇 |
1978年 | 35728篇 |
1977年 | 32417篇 |
1976年 | 29744篇 |
1975年 | 28089篇 |
1974年 | 29191篇 |
1973年 | 28202篇 |
1972年 | 26388篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
H N David M Dhilly M Degoulet G Poisnel C Meckler N Vallée J-é Blatteau J-J Risso M Lemaire D Debruyne J H Abraini 《Translational psychiatry》2015,5(7):e594
We investigated the effects of the noble gas argon on the expression of locomotor sensitization to amphetamine and amphetamine-induced changes in dopamine release and mu-opioid neurotransmission in the nucleus accumbens. We found (1) argon blocked the increase in carrier-mediated dopamine release induced by amphetamine in brain slices, but, in contrast, potentiated the decrease in KCl-evoked dopamine release induced by amphetamine, thereby suggesting that argon inhibited the vesicular monoamine transporter-2; (2) argon blocked the expression of locomotor and mu-opioid neurotransmission sensitization induced by repeated amphetamine administration in a short-term model of sensitization in rats; (3) argon decreased the maximal number of binding sites and increased the dissociation constant of mu-receptors in membrane preparations, thereby indicating that argon is a mu-receptor antagonist; (4) argon blocked the expression of locomotor sensitization and context-dependent locomotor activity induced by repeated administration of amphetamine in a long-term model of sensitization. Taken together, these data indicate that argon could be of potential interest for treating drug addiction and dependence. 相似文献
992.
993.
994.
995.
996.
Abdelhadi Lahoum Nasserdine Sabaou Christian Bijani Noureddine Bouras Frédéric Pont Selma P. Snini Florence Mathieu 《Saudi Pharmaceutical Journal》2019,27(1):56-65
The actinobacterium strain ABH26 closely related to Saccharothrix xinjiangensis, isolated from an Algerian Saharan soil sample, exhibited highly antagonist activity against Gram-positive bacteria, yeasts and filamentous fungi. Its ability to produce antimicrobial compounds was investigated using several solid culture media. The highest antimicrobial activity was obtained on Bennett medium. The antibiotics secreted by strain ABH26 on Bennett medium were extracted by methanol and purified by reverse-phase HPLC using a C18 column. The chemical structures of the compounds were determined after spectroscopic (1H NMR, 13C NMR, 1H-1H COSY and 1H-13C HMBC spectra), and spectrometric (mass spectrum) analyses. Two new cyanogriside antibiotics named cyanogriside I (1) and cyanogriside J (2), were characterized along with three known caerulomycins, caerulomycin A (3), caerulomycin F (4) and caerulomycinonitrile (5). This is the first report of cyanogrisides and caerulomycins production by a member of the Saccharothrix genus. The minimum inhibitory concentrations (MIC) of these antibiotics were determined against pathogenic microorganisms. 相似文献
997.
998.
999.
1000.