全文获取类型
收费全文 | 875篇 |
免费 | 46篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 45篇 |
妇产科学 | 37篇 |
基础医学 | 110篇 |
口腔科学 | 10篇 |
临床医学 | 100篇 |
内科学 | 87篇 |
皮肤病学 | 23篇 |
神经病学 | 87篇 |
特种医学 | 77篇 |
外国民族医学 | 1篇 |
外科学 | 194篇 |
综合类 | 9篇 |
预防医学 | 47篇 |
眼科学 | 18篇 |
药学 | 36篇 |
中国医学 | 1篇 |
肿瘤学 | 37篇 |
出版年
2021年 | 17篇 |
2020年 | 6篇 |
2019年 | 8篇 |
2018年 | 9篇 |
2017年 | 13篇 |
2016年 | 13篇 |
2015年 | 8篇 |
2014年 | 20篇 |
2013年 | 31篇 |
2012年 | 37篇 |
2011年 | 31篇 |
2010年 | 24篇 |
2009年 | 35篇 |
2008年 | 21篇 |
2007年 | 32篇 |
2006年 | 43篇 |
2005年 | 26篇 |
2004年 | 26篇 |
2003年 | 36篇 |
2002年 | 29篇 |
2001年 | 32篇 |
2000年 | 15篇 |
1999年 | 23篇 |
1998年 | 20篇 |
1997年 | 19篇 |
1996年 | 13篇 |
1995年 | 14篇 |
1994年 | 21篇 |
1993年 | 17篇 |
1992年 | 19篇 |
1991年 | 24篇 |
1990年 | 17篇 |
1989年 | 17篇 |
1988年 | 23篇 |
1987年 | 26篇 |
1986年 | 17篇 |
1985年 | 22篇 |
1984年 | 8篇 |
1983年 | 8篇 |
1982年 | 9篇 |
1981年 | 7篇 |
1980年 | 8篇 |
1979年 | 7篇 |
1978年 | 7篇 |
1975年 | 8篇 |
1974年 | 4篇 |
1973年 | 7篇 |
1972年 | 6篇 |
1971年 | 5篇 |
1957年 | 5篇 |
排序方式: 共有922条查询结果,搜索用时 15 毫秒
41.
Characterization of mild whole-body hyperthermia protocols using human breast, ovarian, and colon tumors grown in severe combined immunodeficient mice 总被引:2,自引:0,他引:2 下载免费PDF全文
Repasky EA Tims E Pritchard M Burd R 《Infectious diseases in obstetrics and gynecology》1999,7(1-2):91-97
OBJECTIVE: We have shown that one treatment of fever-like whole body hyperthermia (WBH) on mice bearing human breast tumors results in a tumor growth delay. Our goal was to repeat this study in mice bearing human ovarian or colon tumors. We further evaluated this WBH protocol by performing multiple and interrupted WBH treatments. METHODS: Human tumors were grown in severe combined immunodeficient (SCID) mice. For WBH, core body temperatures were maintained at 39.8+/-0.2 degrees C for 6-8 hours. Multiple treatments were given 6-7 days apart. Interrupted WBH consisted of three 2-hour heatings, 15 minutes apart. Tumor growth time (TGT) was the number of days to grow 1.5 or 2 times in volume. RESULTS: For WBH-treated ovarian tumors, TGT was 12+/-1.2d, compared with 5.0+/-0.1d for untreated mice (P < 0.05). For colon tumors with one WBH treatment TGT was 4.4+/-1.1d. Two and three treatments had TGTs of 9+/-2.3d and 8+/-1.6d. For the untreated tumors, TGT was 2+/-0.7d (P < 0.01 for one, two, and three treatments). Histological examination indicated that one and two treatments were associated with cellular damage within the tumors. With a slower growing colon tumor, the TGT was 24+/-3.3d with three WBH treatments, compared with 14+/-1.8d for controls (P < 0.01). The TGT of breast tumors treated with interrupted WBH was not significantly different than the noninterrupted, with TGT of 7.3+/-0.8d and 6.2+/-1.0d, respectively. CONCLUSIONS: These data illustrate that WBH causes a tumor growth delay in mice bearing human ovarian and colon tumors. This response is enhanced with a second treatment of WBH. Interrupted and noninterrupted WBH give comparable anti-tumor results. We will continue to evaluate WBH in various animal models to optimize its potential for clinical administration and maximize the anti-tumor response. 相似文献
42.
Allan C. Harrington MD Jason M. Cheyney MPAS PA-C LT BSC USAF Tina Kinsley-Scott MD CAPT MSC USAF Robert J. Willard MD MAJ MC USA 《Dermatologic surgery》2004,30(7):1065-1067
Background. Surgery of the digit is facilitated with adequate hemostasis for visualization of the operative field. Several types of tourniquets have been used for this purpose, including glove fingers, Penrose drains, Marmed digital tourniquets, and standard pneumatic tourniquets.
Objective. To present a novel method to achieve hemostasis during surgery of the digit.
Materials. A slightly oversized sterile glove, a hemostat, and a pair of scissors.
Conclusion. We present a novel method to achieve hemostasis using a sterile glove and a hemostat, that allows the surgeon to methodically titrate the amount of compression necessary to attain a bloodless field while minimizing the risks of excessive pressures.
Surgery of the digit is facilitated with adequate hemostasis for visualization of the operative field. Several types of tourniquets have been used for this purpose, including glove fingers, Penrose drains, Marmed digital tourniquets, and standard pneumatic tourniquets. We present a novel method to achieve hemostasis using a sterile glove and a hemostat that allows the surgeon to methodically titrate the amount of compression necessary to attain a bloodless field while minimizing the risks of excessive pressures. 相似文献
Objective. To present a novel method to achieve hemostasis during surgery of the digit.
Materials. A slightly oversized sterile glove, a hemostat, and a pair of scissors.
Conclusion. We present a novel method to achieve hemostasis using a sterile glove and a hemostat, that allows the surgeon to methodically titrate the amount of compression necessary to attain a bloodless field while minimizing the risks of excessive pressures.
Surgery of the digit is facilitated with adequate hemostasis for visualization of the operative field. Several types of tourniquets have been used for this purpose, including glove fingers, Penrose drains, Marmed digital tourniquets, and standard pneumatic tourniquets. We present a novel method to achieve hemostasis using a sterile glove and a hemostat that allows the surgeon to methodically titrate the amount of compression necessary to attain a bloodless field while minimizing the risks of excessive pressures. 相似文献
43.
Templeton AW; Johnson JA; Anderson WH; Cook LT; Dwyer SJ d; Preston DF; Lee KR; Rosenthal SJ; Batnitzky S; Levine E 《Radiology》1984,151(2):527-528
The increasing use of digitally formatted imaging systems requires high-quality interactive gray-scale computer raster graphics systems for the management, display, and analog film recording of digital image and alphanumeric information. These systems are a combination of computer hardware and software and implement a set of graphics protocols. This paper describes a set of interactive graphics protocols that has been developed for clinical use. 相似文献
44.
45.
Barry J. Davis Gail D. Burd Foteos Macrides 《The Journal of comparative neurology》1982,204(4):377-383
Methionine-enkephalin, substance P, and somatostatin immunoreactivities are associated with different classes of neurons in the main olfactory bulb of the hamster. In the glomerular layer, methionine-enkephalin immunoreactivity is observed in the somata and dendrites of periglomerular cells whereas substance P immunoreactivity is present in the somata and dendrites of external tufted cells. Substance P immunoreactivity may also be present in the superficial short axon cells. In the deeper layers, methionine-enkephalin immunoreactivity is observed in a mixed population of neurons which appear to be primarily granule cells, whereas somatostatin immunoreactivity is present only in deep short axon cells. Methionine-enkephalin-, substance P-, and somatostatin-positive fibers of central origin are also observed in the main olfactory bulb. 相似文献
46.
J.F. Burd M. Usategui-Gomez 《Clinica chimica acta; international journal of clinical chemistry》1973,46(3):223-227
A simple, rapid, colorimetric assay for serum lactate dehydrogenase is described. The method requires 0.05 ml serum and a 12-min incubation at 37° and utilizes a tetrazolium salt in conjunction with a stable intermediate electron carrier (Meldola Blue). Good correlation between the colorimetric assay and a reference spectrophotometric assay was observed. 相似文献
47.
Ultrastructural characterization of synaptic terminals formed on newly generated neurons in a song control nucleus of the adult canary forebrain 总被引:9,自引:0,他引:9
The fine structure of synaptic terminals contacting neurons generated in the forebrain of adult male canaries was investigated by autoradiography and electron microscopy. The procedure for labeling the new neurons included pretreating adult canaries with 3H-thymidine and sacrificing them 23-45 days later. Neurons were identified as newly generated by the presence of 3H-thymidine in the cell nucleus. The new neurons in the nucleus hyperstriatum ventralis, pars caudalis (HVc) were identified by autoradiography and light microscopy and examined with electron microscopy. Several types of synaptic terminals contacted the cell body and proximal dendrites of the newly formed neurons. Synaptic junctions were formed by terminals that contained spherical, agranular vesicles, large dense-core vesicles and spherical, agranular vesicles, and pleomorphic or flattened synaptic vesicles. Terminals that contained spherical vesicles were most often associated with asymmetric synaptic densities, and terminals that contained pleomorphic or flattened vesicles formed symmetric junctions. New neurons were also contacted by small terminals that contained few vesicles and had little pre- or postsynaptic density associated with the junction; these terminals may be a special type or may be in the process of developing their synaptic contact with the new neuron. In addition, rare terminals that appeared to be degenerating or to contain debris from other degenerating neural elements contacted new neurons. In summary, these data indicate that the new neurons, which are known to be inserted into existing neural networks, receive synaptic input from at least three different sources. 相似文献
48.
49.
50.
Burd M 《Professional nurse (London, England)》2005,20(8):40-42
Guidelines on the management of hospital waste aim not only to minimise the risks posed to staff at all levels but also to contain potential environmental hazards, such as infection and sharps injuries. It is therefore important for all personnel to be vigilant and to ensure that they dispose of clinical waste safety and appropriately. 相似文献