Arsenik-Vergiftung. (Mordversuch.)

Ohne Zusammenfassung     

Die Bedeutung der Handführung und -stützung bei eigenhändigen Testamenten

Ohne ZusammenfassungNach einem Vortrag, gehalten auf der 18. Tagung der Deutschen Gesellschaft für gerichtliche Medizin in Heidelberg1929.     

Begrüßungsansprache

Ohne Zusammenfassung     

Gesetzgebung. Kriminologie. Gefängniswesen. Strafvollzug

International Journal of Legal Medicine -     

Mammographic findings following reduction mammaplasty

Clinical and mammographic follow-up checks were made on 64 women with a record of breast reduction surgery. Mammographic changes, such as thickened skin, distortion of nipples as well as thickening and dislocation of parenchymal tissue, can be relatively easily differentiated from malignant changes, primarily in cases in which such changes are symmetrical and in which case histories and earlier clinical findings are known. Bilateral calcifications in most cases are caused by calcified fat necrosis.     

Hepatic angiomyolipoma in a 26-year-old Caucasian woman with a history of tibial osteosarcoma

We report on a 26-year-old Caucasian woman who was referred to the Department of Surgery complaining of general malaise, feeling of fullness with occasional vomiting and intermittent jaundice. The patient had previously suffered from tibial osteosarcoma of the left leg which was resected 13 years ago and subsequently treated with radiation and chemotherapy. During clinical investigations a 12 x 12 x 6.5 cm large mass was found in the left lobe of the liver. This was resected, and subsequently shown to be a sporadic hepatic angiomyolipoma. In order to investigate a possible link between the two tumours, we investigated mutations in the p53-gene, loss of heterozygosity (LOH) at p53, Rb and p16, c-Myc expression, and the telomerase activity of the angiomyolipoma and the osteosarcoma. Whilst the tibial osteosarcoma showed LOH at p16, no genetic alterations or increased telomerase activity were found in the angiomyolipoma. The occurrence of both these tumours in this patient is therefore probably a coincidence.     

Metastatic adrenal neuroblastoma in an adult

BACKGROUND: Neuroblastoma (NB) is a common malignancy in children, but rarely occurs in adults. Accepted unfavourable prognostic factors include age > 1 year, low histologic grade and advanced stage, MYCN amplification, chromosomal aberrations, elevations of neuron specific enolase and lactate dehydrogenase, and increased catecholamine metabolites in urine or serum. In adults, abdomen/retroperitoneum are the primary sites and in children the adrenal gland. CASE REPORT: A 51- year-old man was admitted to our hospital with hypertension and a large right retroperitoneal mass. Clinically, phaeochromocytoma was suspected. Tumour resection revealed adrenal NB grade III. Chemotherapy according to the paediatric German Neuroblastoma Trial (NB97) was started. Follow-up computed tomography showed regression of the enlarged mediastinal and retroperitoneal lymph nodes. Because of local and systemic progression palliative radiochemotherapy was started. The patient died 9 months after diagnosis. CONCLUSION: To the best of our knowledge this is the oldest NB patient registered so far in Germany. Currently there are no standard treatment guidelines for patients with NB in adulthood. Collection and evaluation of data in adult patients with this tumour are warranted in order to optimise treatment strategies.