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31.
M.D.Bradley P. Kropp M.D.Mark D. Dabagia M.D.John W. Scott M.D.James E. Lingeman 《Urology》1994,44(6)
We present a patient with tuberous sclerosis and bilateral angiomyolipomaswith a right partial staghorn calculi in which the calculi was managed with a percutaneous nephrolithotomy. Despite the inherent risk of hemorrhage with a percutaneous approach compounded by the fact that this was done directly through a tumor, we were able to render the patient stone free with no intraoperative bleeding, complications, or the need for postoperative blood transfusion. To our knowledge, this is the first reported case of percutaneous nephrolithotomy directly through a renal angiomyolipoma. 相似文献
32.
Sylvia Mitchell Veronica A. Bradley John L. Welch Peter G. Britton 《Brain injury : [BI]》1990,4(3):273-279
This study reports on the efficacy of a 'coma arousal procedure'. This procedure involved a programme of vigorous sensory stimulation administered to comatose patients by relatives using Comakits. An experimental group of 12 severely head-injured patients received the coma arousal procedure while a matched control group did not. Total duration of coma and weekly Glasgow Coma Scale Scores were recorded for the two groups. Results indicate that the total duration of coma was significantly shorter and that coma lightened more rapidly for the experimental group. 相似文献
33.
Hydrogen peroxide-induced endothelial retraction is accompanied by a loss of the normal spatial organization of endothelial cell adhesion molecules. 总被引:3,自引:2,他引:1 下载免费PDF全文
Treatment of confluent monolayers of human umbilical vein endothelial cells with sublethal concentrations of hydrogen peroxide (H2O2) produces reversible cell retraction that opens gaps between adjacent cells. Despite the retraction, adjacent cells remain in contact through a network of dendrite-like processes. Retraction depends on cellular metabolism but not new protein synthesis or protein kinase C. Shape changes induced by H2O2 are accompanied by partial redistribution of actin filaments from the cell periphery in resting endothelial cells to a tangled network of centrally located filaments in H2O2-treated endothelial cells. This change in actin organization is associated with a loss of the normal distribution pattern of surface protein expression. Specifically, beta 1 and beta 3 integrins partly escape from focal adhesion plaques and migrate to the lateral and apical surface of the cell; PECAM-1 redistributes from the lateral borders to the basal surface; and ICAM-1 and ICAM-2 spread from apical caps to the basal surface and to the dendrite-like processes. The likely consequence of endothelial retraction accompanied by abnormal membrane protein distribution is a loss of normal endothelial cell functions. These changes are best considered manifestations of H2O2-induced sublethal injury that may cause endothelial dysfunction. 相似文献
34.
Alternatives in the surgical management of in situ breast cancer. A meta-analysis of outcome 总被引:2,自引:0,他引:2
The surgical management of lobular carcinoma in situ (LCIS) and ductal carcinoma in situ (DCIS) remains controversial. For in situ breast cancer local excision (LE), local excision and radiation therapy (LERT) and mastectomy (MAST) have all been advocated. A search of the English literature found 13 reports concerning the surgical management of LCIS and 12 reports concerning the management of DCIS. The data were combined in a meta-analysis of outcome. As expected, recurrence rates following LE with both LCIS 8.4%) and DCIS (17%) are high. However,the overall mortality following mastectomy for recurrence, LCIS (2.8%) and DCIS (2.3%) does not differ statistically from those treated initially with mastectomy for LCIS (0.9%) and DCIS (1.7%). We conclude from these data that local recurrence after breast conserving procedures for in situ breast cancer does not carry an ominous prognosis. This knowledge should aid in planning individual therapy. 相似文献
35.
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37.
Norman R. I.; Hirst R.; Appadu B. L.; McKay M.; Bradley P.; Griffiths R.; Rowbotham D. J. 《British journal of anaesthesia》1997,78(3):290-295
The decrease in membrane microviscosity of erythrocyte ghosts in the
presence of clinically relevant concentrations of seven inhalation
anaesthetic agents was studied using fluorescence polarization anisotropy
of the membrane incorporated fluorescent probes 1,6-diphenyl-
1,3,5-hexatriene and 1-[4-trimethylammoniumphenyl]-6-phenyl-1,3,5-
hexatriene. All anaesthetic agents produced a dose-dependent decrease in
anisotropy of both probes, indicating decreased membrane microviscosity.
The reduction in anisotropy measured at the minimum alveolar concentration
(ED50) for anaesthesia was related inversely to the anaesthetic potency of
the agent and was directly proportional to the hypothetical concentration
of agent in the membrane calculated from lipid-water partition
coefficients. These findings do not support the hypothesis that volatile
anaesthetic agents act by increasing membrane microviscosity of the bulk
lipid bilayer to produce anaesthesia.
相似文献
38.
J D Bradley K D Brandt B P Katz L A Kalasinski S I Ryan 《The Journal of rheumatology》1992,19(12):1950-1954
Our randomized double blinded comparison of acetaminophen versus analgesic and antiinflammatory doses of ibuprofen in the treatment of 182 subjects with knee osteoarthritis (OA) systematically evaluated soft tissue tenderness and joint swelling. Improvement in these signs of joint inflammation was associated with lessening of disability (p = 0.02), and reduction in rest pain (p = 0.07), but not with the drug treatment regimen. Thus, joint tenderness and swelling, presumptive evidence of synovitis, may not be a priori indications for use of an antiinflammatory drug, or predict greater responsiveness to treatment with an antiinflammatory drug than to a pure analgesic, in symptomatic treatment of patients with knee OA. 相似文献
39.
40.
Richard N. Bradley 《Disease Management & Health Outcomes》2003,11(5):321-325
Acute stroke affects large numbers of people worldwide. It causes significant morbidity and mortality. Data support the hypothesis that the public is not familiar with either the risk factors or the signs of stroke. Educating the public about stroke may result in a lower incidence of the disease as individuals modify their risk factors, and in improved outcomes as a result of reductions in delays to treatment. There is clear and convincing evidence that reducing delays to treatment of patients with acute stroke results in improved outcomes. Public education programs should be broad-based, tailored to individual audiences, and carry a common theme. 相似文献