全文获取类型
收费全文 | 403篇 |
免费 | 9篇 |
专业分类
儿科学 | 1篇 |
基础医学 | 5篇 |
临床医学 | 69篇 |
内科学 | 145篇 |
皮肤病学 | 2篇 |
神经病学 | 1篇 |
特种医学 | 158篇 |
外科学 | 13篇 |
综合类 | 2篇 |
预防医学 | 6篇 |
药学 | 1篇 |
肿瘤学 | 9篇 |
出版年
2022年 | 3篇 |
2021年 | 5篇 |
2020年 | 1篇 |
2018年 | 8篇 |
2017年 | 4篇 |
2016年 | 6篇 |
2015年 | 9篇 |
2014年 | 18篇 |
2013年 | 22篇 |
2012年 | 28篇 |
2011年 | 27篇 |
2010年 | 17篇 |
2009年 | 21篇 |
2008年 | 28篇 |
2007年 | 29篇 |
2006年 | 36篇 |
2005年 | 40篇 |
2004年 | 21篇 |
2003年 | 20篇 |
2002年 | 13篇 |
2001年 | 9篇 |
2000年 | 15篇 |
1999年 | 6篇 |
1998年 | 2篇 |
1997年 | 5篇 |
1995年 | 8篇 |
1994年 | 3篇 |
1993年 | 4篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1983年 | 1篇 |
排序方式: 共有412条查询结果,搜索用时 15 毫秒
131.
132.
133.
134.
Anneline S.J.M. te Riele Cynthia A. James Neda Rastegar Aditya Bhonsale Brittney Murray Crystal Tichnell Daniel P. Judge David A. Bluemke Stefan L. Zimmerman Ihab R. Kamel Hugh Calkins Harikrishna Tandri 《Journal of the American College of Cardiology》2014
Background
Incomplete penetrance and variable expressivity of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) complicate family screening.Objectives
The objective of the present study was to determine the optimal approach to longitudinal follow-up regarding: 1) screening interval; and 2) testing strategy in at-risk relatives of ARVD/C patients.Methods
We included 117 relatives (45% male, age 33.3 ± 16.3 years) from 64 families who were at risk of developing ARVD/C by virtue of their familial predisposition (72% mutation carriers [92% plakophilin-2]; 28% first-degree relatives of a mutation-negative proband). Subjects were evaluated by electrocardiography (ECG), Holter monitoring, signal-averaged ECG, and cardiac magnetic resonance (CMR). Disease progression was defined as the development of a new criterion by the 2010 Task Force Criteria (not the “Hamid criteria”) at last follow-up that was absent at enrollment.Results
At first evaluation, 43 subjects (37%) fulfilled an ARVD/C diagnosis according to the 2010 Task Force Criteria. Among the remaining 74 subjects (63%), 11 of 37 (30%) with complete re-evaluation experienced disease progression during 4.1 ± 2.3 years of follow-up. Electrical progression (n = 10 [27%], including by ECG [14%], Holter monitoring [11%], or signal-averaged ECG [14%]) was more frequently observed than structural progression (n = 1 [3%] on CMR). All 5 patients (14%) with clinical ARVD/C diagnosis at last follow-up had an abnormal ECG or Holter monitor recording, and the only patient with an abnormal CMR already had an abnormal ECG at enrollment.Conclusions
Over a mean follow-up of 4 years, our study showed that: 1) almost one-third of at-risk relatives have electrical progression; 2) structural progression is rare; and 3) electrical abnormalities precede detectable structural changes. This information could be valuable in determining family screening protocols. 相似文献135.
Türkbey B Aras Ö Karabulut N Turgut AT Akpinar E Alibek S Pang Y Ertürk ŞM El Khouli RH Bluemke DA Choyke PL 《Diagnostic and interventional radiology (Ankara, Turkey)》2012,18(1):46-59
Diffusion-weighted magnetic resonance imaging (MRI), which involves the acquisition of a magnetic resonance signal related to the Brownian motion of water protons in tissue, has become a useful technique for assessing tumors. In this article, we review the basic concepts, imaging strategies, and body applications of diffusion-weighted MRI in detecting and monitoring cancer. 相似文献
136.
137.
138.
MS Nacif N Kawel JJ Lee X Chen J Yao A Zavodni CT Sibley JA Lima S Liu DA Bluemke 《Radiology》2012,264(3):876-883
Purpose: To develop a cardiac computed tomographic (CT) method with which to determine extracellular volume (ECV) fraction, with cardiac magnetic resonance (MR) imaging as the reference standard. Materials and Methods: Study participants provided written informed consent to participate in this institutional review board-approved study. ECV was measured in healthy subjects and patients with heart failure by using cardiac CT and cardiac MR imaging. Paired Student t test, linear regression analysis, and Pearson correlation analysis were used to determine the relationship between cardiac CT and MR imaging ECV values and clinical parameters. Results: Twenty-four subjects were studied. There was good correlation between myocardial ECV measured at cardiac MR imaging and that measured at cardiac CT (r = 0.82, P < .001). As expected, ECV was higher in patients with heart failure than in healthy control subjects for both cardiac CT and cardiac MR imaging (P = .03, respectively). For both cardiac MR imaging and cardiac CT, ECV was positively associated with end diastolic and end systolic volume and inversely related to ejection fraction (P < .05 for all). Mean radiation dose was 1.98 mSv ± 0.16 (standard deviation) for each cardiac CT acquisition. Conclusion: ECV at cardiac CT and that at cardiac MR imaging showed good correlation, suggesting the potential for myocardial tissue characterization with cardiac CT. ? RSNA, 2012. 相似文献
139.
140.