全文获取类型
收费全文 | 3769篇 |
免费 | 401篇 |
国内免费 | 252篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 18篇 |
妇产科学 | 62篇 |
基础医学 | 454篇 |
口腔科学 | 133篇 |
临床医学 | 461篇 |
内科学 | 551篇 |
皮肤病学 | 41篇 |
神经病学 | 184篇 |
特种医学 | 111篇 |
外国民族医学 | 2篇 |
外科学 | 360篇 |
综合类 | 632篇 |
现状与发展 | 3篇 |
预防医学 | 310篇 |
眼科学 | 88篇 |
药学 | 464篇 |
2篇 | |
中国医学 | 238篇 |
肿瘤学 | 281篇 |
出版年
2024年 | 10篇 |
2023年 | 61篇 |
2022年 | 148篇 |
2021年 | 208篇 |
2020年 | 144篇 |
2019年 | 140篇 |
2018年 | 149篇 |
2017年 | 137篇 |
2016年 | 146篇 |
2015年 | 184篇 |
2014年 | 212篇 |
2013年 | 177篇 |
2012年 | 283篇 |
2011年 | 295篇 |
2010年 | 177篇 |
2009年 | 137篇 |
2008年 | 182篇 |
2007年 | 180篇 |
2006年 | 213篇 |
2005年 | 182篇 |
2004年 | 116篇 |
2003年 | 102篇 |
2002年 | 90篇 |
2001年 | 97篇 |
2000年 | 101篇 |
1999年 | 108篇 |
1998年 | 57篇 |
1997年 | 76篇 |
1996年 | 51篇 |
1995年 | 36篇 |
1994年 | 36篇 |
1993年 | 26篇 |
1992年 | 32篇 |
1991年 | 33篇 |
1990年 | 23篇 |
1989年 | 15篇 |
1988年 | 11篇 |
1987年 | 14篇 |
1986年 | 8篇 |
1985年 | 9篇 |
1984年 | 2篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 4篇 |
1980年 | 1篇 |
1979年 | 3篇 |
排序方式: 共有4422条查询结果,搜索用时 0 毫秒
71.
April Vassantachart Michael Marietta Shahil Mehta Eugene Lin Shelly X. Bian 《Journal of gastrointestinal oncology.》2022,13(6):2922
BackgroundMortality rates in colorectal cancer (CRC) continue to be higher in Black compared to White patients. While standard treatment modalities for locally advanced rectal cancer have been shown to improve outcomes, there are limited studies assessing the receipt of standard treatment in rectal cancer based on race. Therefore, we sought to evaluate the use of standard treatment across racial groups in locally advanced rectal cancer and its effect on survival.MethodsThe National Cancer Database (NCDB) was queried for patients ≥18 years old with clinical and pathologic stage II–III rectal adenocarcinoma who received treatment from 2004 to 2014. Standard treatment was defined as complete surgical excision with either neoadjuvant or adjuvant concurrent chemoradiation. Multivariable logistic regressions were used to identify racial differences in receiving standard treatment. Cox proportional hazards were used to estimate the effects of standard vs. nonstandard treatment on survival differences based on race.ResultsA total of 70,677 patients with stage II (n=35,079) or stage III (n=35,598) rectal adenocarcinoma met the inclusion criteria. On multivariate analysis, Black [odds ratio (OR): 0.75; 95% confidence interval (CI): 0.71–0.79; P<0.001] and Hispanic White (OR: 0.86; 95% CI: 0.80–0.92; P>0.001) patients were less likely to receive standard treatment compared to non-Hispanic White patients. On multivariable Cox regression, nonstandard treatment was significantly associated with worse survival [hazard ratio (HR): 1.69; 95% CI: 1.65–1.73; P<0.001] compared to standard treatment. Even after adjusting for patient, demographic, and facility characteristics, Black patients had higher mortality rates compared to White patients in the whole population (HR: 1.15; 95% CI: 1.09–1.20; P<0.0001). This survival difference between Black and non-Hispanic White patients persisted in both the standard (HR: 1.10; 95% CI: 1.03–1.19; P=0.008) and nonstandard (HR: 1.17; 95% CI: 1.10–1.25; P<0.0001) treatment subgroups. Decreased survival outcomes in Black patients were more pronounced for those who underwent nonstandard treatment, particularly when treating stage III disease (HR: 1.30; 95% CI: 1.19–1.42; P<0.0001).ConclusionsNonstandard treatment in stage II and III rectal cancer is associated with worse survival compared to standard treatment regimens. Black patients are more likely to receive nonstandard treatment and have worse survival outcomes compared to White patients. 相似文献
72.
骨髓间充质干细胞不同移植方法治疗脊髓损伤的实验研究 总被引:7,自引:0,他引:7
为探讨骨髓基质干细胞(MSCs)不同的移植方法对脊髓损伤修复的影响,我们采用静脉移植、蛛网膜下腔移植或腹腔移植荧光标记MSCs的方法检测MSCs在损伤处的分布迁移情况及运动功能恢复情况。结果显示:各种移植方法在损伤脊髓节段上、下均可检测到荧光标记的MSCs,不同移植方法在损伤脊髓内荧光标记的MSCs数量有所不同。损伤脊髓节段和非损伤脊髓节段内的细胞数量和密度也有明显差异(P<0.05)。BBB评分显示:术后第2d各组平均未超过1分者,移植后的1周内无明显差异(P>0.05);3周后,各组间差异也不大(P>0.05),但各移植组同对照组相比有明显差异(P<0.05)。以上结果提示:通过各种移植方法MSCs均可迁移到损伤脊髓节段,并在该部位存活、聚集和向损伤部位迁移,说明MSCs不同的移植方法对于治疗脊髓损伤均有一定的作用。 相似文献
73.
鼻咽癌(NPC)是一种起源于鼻咽部上皮细胞的恶性肿瘤,是青少年人群头颈部最常见的恶性肿瘤之一。青少年鼻咽癌的治疗通常参照成人治疗指南,但是青少年鼻咽癌有其自身的临床特点。对于处于发育阶段的青少年患者来说,治疗的晚期不良反应也不可忽视。寻找适合青少年的治疗方案具有重要意义。本文对青少年鼻咽癌的流行病学、临床特点、治疗现状... 相似文献
74.
Cardiovascular disease (CVD) is a group of diseases affecting the heart and blood vessels and is the leading cause of morbidity and mortality worldwide. Increasingly more evidence has shown that the senescence of vascular endothelial cells is the key to endothelial dysfunction and cardiovascular diseases. Anthocyanin is a type of water-soluble polyphenol pigment and secondary metabolite of plant-based food widely existing in fruits and vegetables. The gut microbiome is involved in the metabolism of anthocyanins and mediates the biological activities of anthocyanins and their metabolites, while anthocyanins also regulate the growth of specific bacteria in the microbiota and promote the proliferation of healthy anaerobic flora. Accumulating studies have shown that anthocyanins have antioxidant, anti-inflammatory, and anti-aging effects. Many animal and in vitro experiments have also proven that anthocyanins have protective effects on cardiovascular-disease-related dysfunction. However, the molecular mechanism of anthocyanin in eliminating aging endothelial cells and preventing cardiovascular diseases is very complex and is not fully understood. In this systematic review, we summarize the metabolism and activities of anthocyanins, as well as their effects on scavenging senescent cells and cardioprotection. 相似文献
75.
76.
77.
目的探讨实验性自身免疫性心肌炎BALB/C小鼠模型心肌组织中annexin Ⅵ的表达变化及意义。方法1.模型复制合成与心肌肌球蛋白抗原表位具有相同氨基酸序列的多肽,与完全佛氏佐剂混合后于第0、7天在腹股沟和腋下皮下免疫BALB/C小鼠;2.指标检测HE染色光镜下观察模型的炎症情况,间接ELISA法检测小鼠血清中抗肌球蛋白IgG抗体,Western Blot法检测心肌组织中annexin Ⅵ的表达变化。结果光镜下表现与血清学指标均一致提示心肌炎症;annexin Ⅵ检测结果示实验组与对照组相比,第14天、21天、30天组Annexin Ⅵ表达降低,差异具有显著性(P〈0.05);实验组间相比,第14天、21天、30天组与第60天组间均具有显著性差异(P〈0.05)。结论本实验中的多肽可以诱导出心肌炎;炎症急性期annexin Ⅵ表达下降可对抗心肌收缩力的减弱,在心肌炎早期心功能下降过程中起到代偿作用。 相似文献
78.
导乐联合硬膜外阻滞无痛分娩142例效果观察及护理 总被引:1,自引:0,他引:1
目的:探讨导乐联合硬膜外阻滞无痛分娩的镇痛效果与护理方法。方法:将284例产妇随机分为实验组和对照组各142例,实验组采用导乐联合硬膜外阻滞无痛分娩,对照组采用单纯硬膜外阻滞无痛分娩,对两组镇痛效果、并发症、PCA泵实时记录、产程时间、分娩方式、产后出血量及镇痛方法对胎儿、新生儿的影响进行分析比较。结果:两组镇痛效果及并发症发生率比较无显著性差异(P>0.05);实验组平均进药总量、按压次数与实际有效进药次数比值均显著低于对照组(P<0.01);实验组第一产程活跃期及第二产程均显著短于对照组(P<0.01),阴道手术助产率也显著低于对照组(P<0.01);两组胎儿窒息及新生儿窘迫发生率比较无显著性差异(P>0.05)。结论:导乐联合硬膜外阻滞用于无痛分娩,镇痛效果良好,对母婴无不良影响,减少了麻醉药物的用量,减轻了运动神经阻滞对产力的影响,缩短了第一产程活跃期及第二产程,降低了阴道助产率,充分保障了母婴安全,值得推广应用。 相似文献
79.
80.
Yugui Zhang Jiangtao Niu Shujuan Zhang Xinlei Si Tian-Tian Bian Hongwei Wu Donghui Li Yujing Sun Jing Jia Erdan Xin Xingke Yan Yuefeng Li 《Pharmaceutical biology》2022,60(1):1237
ContextHedysari Radix Praeparata Cum Melle (HRPCM) and Astragali Radix Praeparata Cum Melle (ARPCM) are used interchangeably in clinics to treat spleen-qi deficiency (SQD) symptom mainly including gastrointestinal dysfunction and decreased immunity, which has unknown differences in efficacy.ObjectiveTo investigate the differences between HRPCM and ARPCM on intervening gastrointestinal- and immune-function with SQD syndrome.Materials and methodsAfter the SQD model was established, the Sprague–Dawley (SD) rats were randomly divided into nine groups (n = 10): normal; model; Bu-Zhong-Yi-Qi Pills; 18.9, 12.6 and 6.3 g/kg dose groups of HRPCM and ARPCM. Gastrointestinal function including d-xylose, gastrin, amylase vasoactive intestinal peptide, motilin, pepsin, H+/K+-ATPase, Na+/K+-ATPase, sodium-glucose cotransporter 1 (SGLT1), glucose transporter 2 (GLUT2) and immune function including spleen and thymus index, blood routine, interleukin (IL)-2, IL-6, interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α), immunoglobulin (Ig) M, IgA, IgG and delayed-type hypersensitivity (DTH) were detected. Finally, the efficacy differences were analysed comprehensively by the fuzzy matter-element method.ResultsIn regulating immune, the doses differences in efficacy between HRPCM and ARPCM showed in the high-dose (18.9 g/kg), but there were no differences in the middle- and low- dose (12.6 and 6.3 g/kg); the efficacy differences were primarily reflected in levels of IL-6, IFN-γ, TNF-α and IgM in serum, and the mRNA expression of IL-6 and IFN-γ in the spleen. In regulating gastrointestinal, the efficacy differences were primarily reflected in the levels of D-xylose, MTL, and GAS in serum, and the mRNA and protein expression of SGLT1 and GLUT2 in jejunum and ileum.Discussion and conclusionsHRPCM is more effective than ARPCM on regulating gastrointestinal function and immune function with SQD syndrome. Therefore, we propose that HRPCM should be mainly used to treat SQD syndrome in the future. 相似文献