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B. Bertram K.-D. Lemmen H. Agostini F. Ziemssen H.-P. Hammes R. Landgraf 《Der Diabetologe》2016,12(7):509-521
In September 2015 a revised version of the guideline “Prevention and therapy of diabetes-induced retinal complications” was released in Germany. It summarizes current recommendations for diagnosis and therapy of diabetic retinopathy with a special focus on practicability in daily routine. Newly included were the use of optical coherence tomography (OCT) for the diagnosis of diabetic macular edema and the evaluation of the therapeutic effect of anti-VEGF drugs (VEGF: vascular endothelial growth factor) or corticosteroids after intravitreal drug delivery. Screening intervals for diabetic retinopathy were extended to every 2 years for all diabetic patients with no retinopathy and limited systemic risk factors. Patients with known risk factors should be screened annually or in case of retinopathy, followed-up as recommended by the ophthalmologist. 相似文献
84.
S W Werns M J Shea A Vaporciyan S Phan G D Abrams A J Buda B Pitt B R Lucchesi 《Journal of the American College of Cardiology》1987,9(4):898-902
Previous studies demonstrated that treatment with superoxide dismutase, a scavenger of superoxide anions, limits the extent of myocardial injury in a canine preparation of regional myocardial ischemia and reperfusion. Little is known, however, about the effects of superoxide dismutase on the healing of a myocardial infarct. Therefore, this study was performed to determine whether treatment with superoxide dismutase during myocardial ischemia impairs formation of scar tissue after infarction. Dogs received 2 hour infusions of superoxide dismutase or albumin (controls) by way of the left atrium beginning 15 minutes before and ending 15 minutes after a 90 minute occlusion of the left circumflex coronary artery. Six weeks later the animals were killed. Two-dimensional echocardiography was performed before surgery and before induced death. Wall thickening in the central ischemic zone was decreased at 6 weeks compared with baseline studies (p less than 0.05), but the decrease was similar for both groups. The hydroxyproline concentrations (microgram/mg dry weight) of the scar tissue in the superoxide dismutase and control groups, respectively, were 35.3 +/- 3.8 and 28.7 +/- 5.0 (p less than 0.05). The ratios of the scar thickness to normal wall thickness were superoxide dismutase 0.91 +/- 0.03 and control 0.89 +/- 0.03 (p greater than 0.05). Thus, superoxide dismutase had no adverse effect on wall thickening or scar formation assessed 6 weeks after myocardial infarction, and may be useful to limit oxygen radical-mediated damage during reperfusion of the ischemic myocardium. 相似文献
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Burcin
zdirik Henning Jann Philip Bischoff Uli Fehrenbach Frank Tacke Christoph Roderburg Bertram Wiedenmann 《Medicine》2021,100(1)
Immune check-point inhibitors (ICIs) have changed our view on how to treat cancer. Despite their approval in treatment of many different cancers, efficacy of immune check-point inhibitors (ICI) in neuroendocrine neoplasia is limited and poorly understood. Established treatment options of neuroendocrine tumors (NET) and neuroendocrine carcinomas (NECs) are based on surgery, tumor-targeted medical treatments, Peptide Receptor Radionuclide Therapy (PRRT), and locoregional therapies. However, in many patients these treatments lose efficacy over time, and novel therapies are urgently needed. We report on 8 patients diagnosed with neuroendocrine neoplasms (NEN) that were treated with ICI (pembrolizumab, avelumab, nivolumab plus ipilimumab) as salvage therapy. In this cohort, we observed tumor response with partial remission in 3 patients and stable disease in 1 patient. Four patients showed progressive disease. Of note, responses were observed both in PD-L1 positive and PD-L1 negative patients. Here, we discuss clinical courses of these patients in the context of available literature to highlight limitations and drawbacks currently preventing the use of ICI in routine management of patients with NEN. 相似文献
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Lars Nyberg Fredrik Magnussen Anders Lundquist William Baar David Bartrs-Faz Lars Bertram C. J. Boraxbekk Andreas M. Brandmaier Christian A. Drevon Klaus Ebmeier Paolo Ghisletta Richard N. Henson Carme Junqu Rogier Kievit Maike Kleemeyer Ethan Knights Simone Kühn Ulman Lindenberger Brenda W. J. H. Penninx Sara Pudas
ystein Srensen Lídia Vaqu-Alczar Kristine B. Walhovd Anders M. Fjell 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(18)
Education has been related to various advantageous lifetime outcomes. Here, using longitudinal structural MRI data (4,422 observations), we tested the influential hypothesis that higher education translates into slower rates of brain aging. Cross-sectionally, education was modestly associated with regional cortical volume. However, despite marked mean atrophy in the cortex and hippocampus, education did not influence rates of change. The results were replicated across two independent samples. Our findings challenge the view that higher education slows brain aging. 相似文献
90.
Dr. Robert C. Smith MD Jennifer A. Mettler MA Bertram E. Stöffelmayr PhD Judith S. Lyles MA Alicia A. Marshall PhD Lawrence F. Van Egeren PhD Gerald G. Osborn DO Valerie Shebroe PhD 《Journal of general internal medicine》1995,10(6):315-320
OBJECTIVE: To evaluate an intensive training program’s effects on residents’ confidence in their ability in, anticipation of positive
outcomes from, and personal commitment to psychosocial behaviors.
DESIGN: Controlled randomized study.
SETTING: A university- and community-based primary care residency training program.
PARTICIPANTS: 26 first-year residents in internal medicine and family practice.
INTERVENTION: The residents were randomly assigned to a control group or to one-month intensive training centered on psychosocial skills
needed in primary care.
MEASUREMENTS: Questionnaires measuring knowledge of psychosocial medicine, and self-confidence in, anticipation of positive outcomes from,
and personal commitment to five skill areas: psychological sensitivity, emotional sensitivity, management of somatization,
and directive and nondirective facilitation of patient communication.
RESULTS: The trained residents expressed higher self-confidence in all five areas of psychosocial skill (p<0.03 for all tests), anticipated
more positive outcomes for emotional sensitivity (p=0.05), managing somatization (p=0.03), and nondirectively facilitating
patient communication (p=0.02), and were more strongly committed to being emotionally sensitive (p=0.055) and managing somatization
(p=0.056), compared with the untrained residents. The trained residents also evidenced more knowledge of psychosocial medicine
than did the untrained residents (p<0.001).
CONCLUSIONS: Intensive psychosocial training improves residents’ self-confidence in their ability regarding key psychosocial behaviors
and increases their knowledge of psychosocial medicine. Training also increases anticipation of positive outcomes from and
personal commitment to some, but not all, psychosocial skills.
Presented at the annual meeting of the Society of General Internal Medicine, Washington, DC, April 27–29, 1994.
Supported by the Fetzer Institute in Kalamazoo, MI. 相似文献