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11.
Renal complications of lipodystrophy: A closer look at the natural history of kidney disease
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Baris Akinci Sadiye Mehtat Unlu Ali Celik Ilgin Yildirim Simsir Sait Sen Banu Nur Fatma Ela Keskin Basak Ozgen Saydam Nilufer Kutbay Ozdemir Banu Sarer Yurekli Bekir Ugur Ergur Melda Sonmez Tahir Atik Atakan Arslan Tevfik Demir Canan Altay Ulku Aybuke Tunc Tugba Arkan Ramazan Gen Erdal Eren Gulcin Akinci Aslihan Arasli Yilmaz Habib Bilen Samim Ozen Aygul Celtik Senay Savas Erdeve Semra Cetinkaya Huseyin Onay Sulen Sarioglu Elif Arioglu Oral 《Clinical endocrinology》2018,89(1):65-75
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Ila Datar Xiaoliang Qiu Hong Zhi Ma Miranda Yeung Shweta Aras Ivana de la Serna Fahd Al-Mulla Jean Paul Thiery Robert Trumbly Xuan Fan Hongjuan Cui Kam C. Yeung 《Oncotarget》2015,6(36):39050-39061
Accumulating evidence suggests that presence of macrophages in the tumor microenvironment add to the invasive and tumor-promoting hallmarks of cancer cells by secreting angiogenic and growth factors. RKIP is a known metastasis suppressor and interferes with several steps of metastasis. However, the mechanistic underpinnings of its function as a broad metastasis suppressor remain poorly understood. Here, we establish a novel pathway for RKIP regulation of metastasis inhibition through the negative regulation of RANTES/CCL5 thereby limiting tumor macrophage infiltration and inhibition of angiogenesis. Using a combination of loss- and gain-of-function approaches, we show that RKIP hinders breast cancer cell invasion by inhibiting expression of the CC chemokine CCL5 in vitro. We also show that the expression levels of RKIP and CCL5 are inversely correlated among clinical human breast cancer samples. Using a mouse allograft breast cancer transplantation model, we highlight that ectopic expression of RKIP significantly decreases tumor vasculature, macrophage infiltration and lung metastases. Mechanistically, we demonstrate that the inhibition of the CCL5 expression is the cause of the observed effects resulting from RKIP expression. Taken together, our results underscore the significance of RKIP as important negative regulator of tumor microenvironment. 相似文献
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Andre R. Dur?es Milena A. O. Dur?es Luis C. L. Correia Roque Aras 《Arquivos brasileiros de cardiologia》2013,101(5):466-471
Heart valve prosthesis unquestionably improve quality of life and survival of
patients with severe valvular heart disease, but the need for antithrombotic therapy
to prevent thromboembolic complications is a major challenge to clinicians and their
patients. Of the articles analyzed, most were retrospective series of cases or
historical cohorts obtained from the database. The few published randomized trials
showed no statistical power to assess the primary outcome of death or thromboembolic
event. In this article, we decided to perform a systematic literature review, in an
attempt to answer the following question: what is the best antithrombotic strategy in
the first three months after bioprosthetic heart valve implantation (mitral and
aortic)?After two reviewers applying the extraction criteria, we found 1968 references,
selecting 31 references (excluding papers truncated, which combined bioprosthesis
with mechanical prosthesis, or without follow-up).Based on this literature review, there was a low level of evidence for any
antithrombotic therapeutic strategy evaluated. It´s therefore interesting to use
aspirin 75 to 100 mg / day as antithrombotic strategy after bioprosthesis replacement
in the aortic position, regardless of etiology, for patients without other risk
factors such as atrial fibrillation or previous thromboembolic event. In the mitral
position, the risk of embolism, although low, is more relevant than in the aortic
position, according to published series and retrospective cohorts comprised mostly of
elderly non-rheumatic patients.The current evidence is limited to have a consistent and safe level of evidence
regarding the best therapeutic strategy. Based on these studies, 75 to 100 mg/day of
aspirin is interesting as antithrombotic strategy after implantation of aortic
bioprosthesis, regardless of etiology, for patients with no other risk factors such
as atrial fibrillation or previous thromboembolic event. As for mitral bioprosthesis,
the risk of embolism, although low, is more relevant than in the aortic position,
according to published series and retrospective cohorts - usually elderly non
rheumatic patients. 相似文献
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Tugba Mandal Şenay Aydın Dilek Kanmaz Ahmet Levent Karasulu Gülfidan Aras Esin Tuncay 《Sleep & breathing》2016,20(3):1021-1027