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81.
Krimer LS; Hyde TM; Herman MM; Saunders RC 《Cerebral cortex (New York, N.Y. : 1991)》1997,7(8):722-731
The entorhinal cortex (ERC) has been implicated in the pathophysiology of
Alzheimer's disease, schizophrenia and other disorders affecting cognitive
functions. While powerful anatomical and histochemical methods
(immunohistochemistry, in situ hybridization, etc.) may be applied
(although with limitations) to postmortem human brain, each analysis should
utilize a cytoarchitectonic approach to provide appropriate comparisons
within the subdivisions of the ERC. Accordingly, we describe here the
normal cyto- and myeloarchitecture of the human ERC as a prerequisite for
the accompanying study of this region in schizophrenia. Our parcellation of
this cortex differs from previous treatments in three ways. First, we
adopted specific criteria of inclusion to define each subdivision of the
region. Although distinctive ERC features are most prominent in the
intermediate portion of this region, at least one of these features was
considered the minimum necessary criterion to include adjacent tissue in
the entorhinal area. Second, we used morphometric measurements (neuronal
size and density as well as subdivisional volume and laminar thickness) to
support our qualitative evaluation. Third, we have applied to the human ERC
the conventional cytoarchitectonic nomenclature of the entorhinal cortex
used previously in studies of non-human primates. This allows a more
accurate extrapolation of the available numerous experimental anatomical,
physiological and psychological data on this region to the human. As in the
monkey, the five main subareas were recognized in the human (prorhinal,
lateral, intermediate, sulcal and medial) but three required further
subdivision (intermediate, sulcal and medial). The morphometric results
obtained suggested a progression of the human entorhinal cortex from the
peripheral to the central subareas, with the intermediate subarea (281) as
the most complete entorhinal subdivision. Compared with non-human primates,
the human ERC not only retains the basic periallocortical organization but
also demonstrates further evolution. Taken together with available
experimental data on the connectivity of this brain region, these results
provide an anatomical basis for evaluating the ERC in human behavior.
相似文献
82.
Colin T Walsh Yong Wei M Guillaume Wientjes Jessie LS Au 《Journal of translational medicine》2008,6(1):4
Background
The role of basic fibroblast growth factor (bFGF) in chemoresistance is controversial; some studies showed a relationship between higher bFGF level and chemoresistance while other studies showed the opposite finding. The goal of the present study was to quantify bFGF levels in archived tumor tissues, and to determine its relationship with chemosensitivity. 相似文献83.
硝基甘油对狗缺血区冠脉循环的作用 总被引:1,自引:0,他引:1
用实验性犬冠脉狭窄模型,冠脉内恒流灌注硝基甘油0.5μg/kg.min-1,使冠脉血流量(CBF)增加、远端小动脉压(DCP)、冠脉血管总阻力(RT)、小冠脉血管阻力(RS)及冠状静脉低切血粘(ηb)减少;而主动脉压和心率无明显变化。恒流灌注硝基甘油1μg/kg.min-1时,在开始5min内冠脉循环的变化同上,并伴大冠脉血管阻力(RL)减少,10 min后出现CBF减少和RT,RL及ηb增加。结果提示,硝基甘油有缓解和加重心肌缺血的双重作用,其作用可能与剂量张扩张远端小动脉压的程度有关。 相似文献
84.
O. DANIËLS J. HOPMAN S. DE KNECHT A. VAN OORT H. BUSCH 《Acta paediatrica (Oslo, Norway : 1992)》1986,75(S329):44-52
ABSTRACT. The pulsed Doppler principle enables us to study the bloodflow velocity at specific points in the heart and great vessels. In such aorto-pulmonary connections as patent dnctus arteriosus, aorto-pulmonary window and truncus arteriosus the bloodflow velocity patterns are typical of the malformation. Based on knowledge of these abnormal flow patterns the diagnoses of these malformations can be made. 相似文献
85.
86.
87.
中国大陆地区妇女骨质疏松筛选工具探讨 总被引:3,自引:0,他引:3
张菊英 吴涛 杨定焯 程晓光 周琦 卓铁军 张华寿 项静 王洪复 区品中 刘建立 徐苓 黄公怡 黄琪仁 Barden HS Weynand LS Fqukner KG 孟迅吾 《中国修复重建外科杂志》2007,21(1):86-89
目的建立适用于中国大陆地区40岁及以上妇女的骨质疏松(osteoporosis,OP)筛选工具。方法以20~39岁妇女腰椎骨密度的均数和标准差作为参考值计算T—score。以双能X线骨密度仪(dual—energy X—ray absorptiometry,DxA)的测量结果作为金标准,采用二分类的Bayes判别分析,建立判别函数。结果我国大陆地区40岁及以上妇女OP筛选工具(osteoporosis screening tool for Chinese,OSTC)为:体重-2×年龄+50。判别准则为OSTC〉0为无OP危险性,OSTC≤0为有OP危险性。OSTC的正判率为75.78%,灵敏度为76.8%,特异度为75.1%,Kappa值为0.51(P=0.000),说明OSTC与DXA的判定结果一致性尚可。结论OSTC是一个简便的OP筛选工具。根据年龄、体重两个变量的简单计算,即可对我国大陆地区40岁及以上的妇女进行OP危险性的筛选。但OSTC没有得到外部数据的验证,其优劣还有待进一步评价。 相似文献
88.
AM Roelants-van Rijn J van der Grond LS de Vries F Groenendaal 《Acta paediatrica (Oslo, Norway : 1992)》2001,90(11):1288-1291
During venoarterial extracorporeal membrane oxygenation the right carotid artery is ligated in a hypoxic neonate. The aim of the present study was to compare the morphology and metabolism of the left and right basal ganglia in 10 neonates after extracorporeal membrane oxygenation, using proton magnetic resonance imaging and spectroscopy. Data could be obtained in 9 neonates. No significant metabolic differences were found between either the left or right basal ganglia, despite a small right-sided thalamic infarct in one child. Metabolism was normal in all cases. All the infants showed symmetrical neurodevelopment.
Conclusion: Ligation of the right carotid artery for venoarterial extracorporeal membrane oxygenation did not produce persistent changes in brain metabolism in the basal ganglia in this small group of patients. 相似文献
Conclusion: Ligation of the right carotid artery for venoarterial extracorporeal membrane oxygenation did not produce persistent changes in brain metabolism in the basal ganglia in this small group of patients. 相似文献
89.
90.
Matthew J Thurtell FRACP Alison LS Chiu FRANZCO Lucy A Goold MM Gulden Akdal MD John L Crompton FRANZCO Rebekah Ahmed FRACP Simon N Madge FRCOphth Dinesh Selva FRANZCO Ian Francis FRANZCO Raf Ghabrial FRANZCO Arj Ananda FRACS John Gibson FRACP Raymond Chan FRACP Elizabeth O Thompson FRANZCR Michael Rodriguez FRCPA Peter J McCluskey FRANZCO G Michael Halmagyi FRACP 《Clinical & experimental ophthalmology》2013,41(6):567-576