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151.
Impact of Small Renal Ischemia in Hypertension Development: Renovascular Hypertension Caused by Small Branch Artery Stenosis
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![点击此处可从《Journal of clinical hypertension (Greenwich, Conn.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
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Hao Lu MD Yijun Liu MD Wenyong Xie MD Hui Liang BM Hao Guo MD Yuan Quan MM Boyu Zhang MM Canjun Zeng MD PhD Hailin Xu MD 《Orthopaedic Surgery》2023,15(7):1790-1798
Objective
There is a new medial malleolar fracture classification based on 3D CT reconstruction. However, there is no study assessing the reliability and accuracy of the new classification system and comparison between the new and the classic classification. This study aimed to compare the reliability and accuracy of the medial malleolar fracture classification based on 3D CT reconstruction and the Herscovici classification system.Methods
We retrospectively analyzed the consecutive ankle fractures in our hospital from January 2013 to September 2020. Five inexperienced and five experienced orthopedic surgeons were included as observers to assess 68 cases with medial malleolar fractures. Ten evaluators classified the cases according to the two classification systems. The reference results of each case were made by the consensus of three senior trauma surgeons. The interobserver reliability, intraobserver reliability, and accuracy were evaluated at an interval of 6 weeks using Fleiss's kappa (κ) statistics.Results
We found substantial interobserver and intraobserver reliability and 81.4% accuracy for the new classification, which was statistically superior to the Herscovici classification (P < 0.05). The reliability and accuracy of both classifications were similar in inexperienced and experienced groups, except for type III in the new classification. The interobserver reliability of type II was the best (P < 0.05), and the intraobserver reliability of IVc ranked the worst (P < 0.05) in the new classification.Conclusion
The reliability and accuracy of the new classification are superior to the Herscovici classification. Clinical experiences will not affect the assessment of both classification systems in most instances. 相似文献157.
Tianci Yu BM Zongyan Cai BM Xingyu Chang BM Chengwei Xing BM Sylvia White PhD Xiaoxue Guo BM Jiaxin Jin MD 《Orthopaedic Surgery》2023,15(9):2244-2259
Osteosarcoma (OS) is a common malignant bone tumor that occurs mostly in children and adolescents. At present, surgery after chemotherapy or postoperative adjuvant chemotherapy is the main treatment plan. However, the efficacy of chemotherapeutic drugs is limited by the occurrence of chemotherapeutic resistance, toxicity to normal cells, poor pharmacokinetic performance, and drug delivery failure. The delivery of chemotherapy drugs to the bone to treat OS may fail for a variety of reasons, such as a lack of selectivity for OS cells, initial sudden release, short-term release, and the presence of biological barriers (such as the blood-bone marrow barrier). Nanomaterials are new materials with at least one dimension on the nanometer scale (1–100 nm) in three-dimensional space. These materials have the ability to penetrate biological barriers and can accumulate preferentially in tumor cells. Studies have shown that the effective combination of nanomaterials and traditional chemotherapy can significantly improve the therapeutic effect. Therefore, this article reviews the latest research progress on the use of nanomaterials in OS chemotherapy. 相似文献
158.
Percutaneous hepatic perfusion with melphalan in uveal melanoma: A safe and effective treatment modality in an orphan disease
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![点击此处可从《Journal of surgical oncology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Ioannis Karydis MB BCh DPhil Alexandra Gangi MD Matthew J. Wheater BM PhD FRCP Junsung Choi MD Iain Wilson MEng BMBS MRCS FRCR Kerry Thomas MD Neil Pearce DM FRCS Arjun Takhar BMEd Sci BMBS PhD Sanjay Gupta MBBS FRCA Danielle Hardman BS Sean Sileno BS Brian Stedman BSc MBBS FRCS FRCR Jonathan S. Zager MD Christian Ottensmeier MD PhD 《Journal of surgical oncology》2018,117(6):1170-1178
Background
Metastatic uveal melanoma (UM) carries a poor prognosis; liver is the most frequent and often solitary site of recurrence. Available systemic treatments have not improved outcomes. Melphalan percutaneous hepatic perfusion (M‐PHP) allows selective intrahepatic delivery of high dose cytotoxic chemotherapy.Methods
Retrospective analysis of outcomes data of UM patients receiving M‐PHP at two institutions was performed. Tumor response and toxicity were evaluated using RECIST 1.1 and Common Terminology Criteria for Adverse Events (CTCAE) v4.03, respectively.Results
A total of 51 patients received 134 M‐PHP procedures (median of 2 M‐PHPs). 25 (49%) achieved a partial (N = 22, 43.1%) or complete hepatic response (N = 3, 5.9%). In 17 (33.3%) additional patients, the disease stabilized for at least 3 months, for a hepatic disease control rate of 82.4%. After median follow‐up of 367 days, median overall progression free (PFS) and hepatic progression free survival (hPFS) was 8.1 and 9.1 months, respectively and median overall survival was 15.3 months. There were no treatment related fatalities. Non‐hematologic grade 3‐4 events were seen in 19 (37.5%) patients and were mainly coagulopathic (N = 8) and cardiovascular (N = 9).Conclusions
M‐PHP results in durable intrahepatic disease control and can form the basis for an integrated multimodality treatment approach in appropriately selected UM patients. 相似文献159.
160.
Predictors of premature termination from psychotherapy for anorexia nervosa: Low treatment credibility,early therapy alliance,and self‐transcendence
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![点击此处可从《The International journal of eating disorders》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Jennifer Jordan PhD Virginia V. W. McIntosh PhD Frances A. Carter PhD Peter R. Joyce MD PhD DSC FRSNZ FRANZCP Christopher M. A. Frampton PhD Suzanne E. Luty BM BS PhD FRANZCP Janice M. McKenzie MB ChB FRANZCP Janet D. Carter PhD Cynthia M. Bulik PhD 《The International journal of eating disorders》2017,50(8):979-983