CAN WE SATISFY OUR CLIENTS? INTROSPECTION

Criticism of medical professionals is on the rise. The perception of the medical profession and the media, which educates the clientele, is widely different. The likely causes for dissatisfaction of the clientele and some possible solutions are presented.KEY WORDS: Armed Forces Medical Services, Medical care, Cost effective     

Organization, expression and polymorphism of the human persyn gene

Persyn is a recently identified member of the synuclein family with a distinct pattern of expression during pre- and postnatal development of the mouse peripheral and central nervous systems. As with other synucleins, persyn is believed to be involved in the pathogenesis of human neurodegenerative diseases. However, in contrast to other synucleins, high levels of persyn mRNA expression were also found in advanced breast carcinomas, suggesting an involvement of the encoded protein in breast tumour progression. Here we have used an antibody specific to human persyn to demonstrate that the level of this protein is increased in ageing cerebral cortex and in breast tumours. We cloned, characterized and sequenced the human persyn genomic locus and localized it to the long arm of chromosome 10 in the q23.2-q23.3 region. Sequence information was used to search for specific mutations in the protein coding regions of persyn mRNA and the persyn gene in breast tumours and tumour cell lines. No tumour-specific mutations were found, but two linked polymorphisms in the coding region were detected, both in mRNA and exons III and IV of the gene. These results suggest that development of breast tumours correlates with overexpression of the wild-type persyn protein. Detailed characterization of the human persyn locus is important for further studies of the involvement of persyn in neurodegeneration and malignancy.      

性病患者100例心理状况分析

1临床资料2003-03/2004-12就诊性病患者100(男68,女32)例;年龄19～60岁;文化程度中学以下78例,大专以上22例;职业个体49例,有工作单位39例,无业12例;病种尖锐湿疣52例、非淋菌性尿道炎20例、淋病18例、梅毒3例、生殖器疱疹7例; 96例经0.5～6.0 mo的治疗康复,4例病情好转. 接诊过程从交谈及肢体语言发现,98%的患者就诊时对病史遮遮掩掩,甚至隐瞒,觉得羞耻,见不得人,愧对家人;68%的患者由于对性病的一知半解,存在有恐惧感、悲观、自责、压抑、焦虑的情绪表现;36%的患者担心家人、同事知道病情而引发一系列家庭、工作问题[1];43%的患者担心病情加重、扩散、传染家人、治疗后复发、未彻底治愈以及治疗费用太高等.     

女大学生痛经80例分析

1 临床资料 门诊女大学生痛经患80例,均系原发性痛经．年龄18～26岁．城市女生56例,占70％,农村女生24例,占30％．腹坠胀感52例,占65％;性情急躁16例,20％;下腹痛12例,占15％．性情急躁并下腹痛8例,占10%;腹坠胀感、性情急躁并下腹痛6例,占7．5％．对月经疼痛缺乏正确认识恐惧32例,占40%;经期进行剧烈运动66例,占82．5%;经期注意饮食调整,讲究膳食营养42例,占52．5％;     

Initial Management of Burns

Burns is a preventable tragedy, which is unfortunately still common in India. The possibility of disfigurement, death and emotional trauma as a result of burns is a shattering experience to the victim as well as his/her family. Proper initial management can salvage many such unfortunate victims. Burns patients require close monitoring, barrier nursing and sympathetic attitude of medical and paramedical staff in a burns ICU to have a reasonable chance of survival.Key Words: Burns, Inhalation injury, Resuscitation, Wound management     

High-resolution real-time ultrasonography of thyroid nodules

High-resolution real-time ultrasonography was used to evaluate 98 patients with palpable abnormalities of the thyroid and positive isotopic studies. It confirmed 37 of 73 (51%) suspected solitary nodules. Of 25 patients thought to have multinodular goiter, sonography was supportive in 21 (84%). In patients with adenoma or adenomatous nodules, characteristic features included a sonolucent "halo". Colloid nodules tended to be more sonolucent than normal thyroid tissue, whereas Hashimoto thyroiditis was characterized by an enlarged gland and decreased echogenicity.     

Adrenal abscess in the neonate

Adrenal abscess in the neonate is a rare complication of adrenal hemorrhage. The radiographic and clinical findings of 12 previously published cases and two new cases of adrenal abscess in the newborn are presented. Sonography was the most helpful examination in distinguishing a suprarenal lesion from an intrarenal lesion and in demonstrating the morphology of the abscess.     

脑源性神经营养因子对周围神经修复与再生的促进效应

目的:观察脑源性神经营养因子对周围神经损伤修复与再生的作用。方法:实验于2000-06/2002-08在大连医科大学神经解剖研究室完成。取健康SD大鼠24只,体质量180～200g,雌雄各半。腹腔内麻醉后,暴露左、右侧坐骨神经,在距梨状肌出口侧1.0cm处切除5mm长的坐骨神经,两断端用硅胶管桥接形成神经再生室。局部用药右侧再生室内注入0.5mL脑源性神经营养因子作为实验组,左侧再生室内注入生理盐水0.5mL作为对照组,观察局部应用脑源性神经营养因子对神经再生的影响。实验评估:术后9周对动物进行损伤肢体行为功能评价、小腿三头肌湿重测定、轴突计算机图像分析轴突数目及直径。结果:纳入SD大鼠24只,均进入结果分析。①各组动物精神状态及行为变化:对照组大鼠第3～4周时出现脱趾、溃疡加剧至第9周仍无愈合及减轻迹象。实验组于第4～5周时溃疡相继愈合,至9周时基本恢复正常。②小腿三头肌湿重测定:实验组明显重于对照组,差异显著[(0.677±0.112),(0.546±0.155)g,P<0.01]。③轴突计算机图像分析轴突计数及直径:实验组均高于对照组,差异显著[轴突数目:(2.361±0.180)×103,(1.757±0.113)×103个,P<0.01;轴突直径:(0.800±0.120),(0.530±0.170)μm,P<0.01]。结论:局部应用脑源性神经营养因子对周围神经再生有明显的促进作用。