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61.
Takahiro Arima Osamu Nagata Takeshi Miura Katsuki Ikeda Tomoya Mizushima Azusa Takahashi Koji Sakaida 《The American journal of emergency medicine》2014
Study objective
This study sought to determine and compare the utility of the Airway scope (AWS; Pentax Corporation, Tokyo, Japan) and the conventional Macintosh laryngoscope (MLS) for intubation in the prehospital setting.Methods
In this randomized controlled trial in the prehospital setting, the primary outcome was time required for intubation, and the secondary outcomes were ultimate success, first attempt success, and difficulty of intubation. The intent-to-treat principle was used to analyze time to intubation. Ultimate success was defined as intubation completed within 600 s regardless of the device ultimately used.Results
A total of 109 patients, primarily with cardiac arrest, were randomly assigned to the AWS or MLS arms. Median time (interquartile range) to intubation was 155 (71-216) s with the AWS versus 120 (60-170) s with the MLS (P = .095). Ultimate success rate was slightly lower with the AWS (96.4%) than with the MLS (100%) (P = .496), while the first attempt success rate was significantly lower (46% and 75%, respectively; P = .002). There was no significant difference in difficulty of intubation (P = .066). Multivariate logistic regression analysis revealed that cervical immobilization and oral contamination, such as vomit, was associated with first attempt success (odds ratio [95% confidence interval]: 0.11 [0.01-0.87] and 0.43 [0.18-0.99], respectively).Conclusion
Despite its many advantages seen in other settings, the AWS did not show superior efficacy to the MLS in relation to time required for intubation, ultimate or first attempt success rate, or difficulty level of intubation in the prehospital setting. 相似文献62.
Azusa Tanimoto Tadaaki Yamada Shigeki Nanjo Shinji Takeuchi Hiromichi Ebi Kenji Kita Kunio Matsumoto Seiji Yano 《Oncotarget》2014,5(13):4920-4928
Alectinib is a new generation ALK inhibitor with activity against the gatekeeper L1196M mutation that showed remarkable activity in a phase I/II study with echinoderm microtubule associated protein-like 4 (EML4) - anaplastic lymphoma kinase (ALK) non-small cell lung cancer (NSCLC) patients. However, alectinib resistance may eventually develop. Here, we found that EGFR ligands and HGF, a ligand of the MET receptor, activate EGFR and MET, respectively, as alternative pathways, and thereby induce resistance to alectinib. Additionally, the heat shock protein 90 (Hsp90) inhibitor suppressed protein expression of ALK, MET, EGFR, and AKT, and thereby induced apoptosis in EML4-ALK NSCLC cells, even in the presence of EGFR ligands or HGF. These results suggest that Hsp90 inhibitors may overcome ligand-triggered resistance to new generation ALK inhibitors and may result in more successful treatment of NSCLC patients with EML4-ALK. 相似文献
63.
Shiroh Miura Kengo Kosaka Ryuta Fujioka Yusuke Uchiyama Tomofumi Shimojo Takuya Morikawa Azusa Irie Takayuki Taniwaki Hiroki Shibata 《European journal of medical genetics》2019,62(3):172-176
Spinocerebellar ataxia 27 (SCA27) is an autosomal dominant SCA caused by variants in the fibroblast growth factor 14 (FGF14) gene. We examined a Japanese SCA patient whose deceased father also suffered from SCA. The patient was a 63-year-old male. He graduated from junior high school but received no further education. The predominant complaint was slowly progressive dysarthria and gait disturbance, which appeared at age 47. He showed pathological saccadic dysmetria, saccadic intrusions into smooth pursuit eye movements, dysarthria, and limb and truncal ataxia. His gait was wide-based but he did not require a walking stick. Limb muscle strength was intact. Deep tendon reflexes were normal or slightly reduced. Pathological reflexes were absent. He demonstrated mildly impaired vibration sense in the lower limbs. There was no urinary dysfunction. Brain MRI showed cerebellar atrophy without brainstem involvement. We first confirmed the absence of repeat expansion in genes known to be responsible for SCAs 1–3, 6–8, 10, 12, 17, 36 and dentatorubral-pallidoluysian atrophy. By exome analysis, we identified a novel heterozygous variant (NM_004115, c.529A>T; Lys177X) in exon 4 of the FGF14 gene. This variant is expected to generate a truncated FGF14 protein lacking the heparin binding sites, those are likely to modify the activity of FGF14. We confirmed the absence of the variant in 502 healthy Japanese individuals by Sanger sequencing. There is no record of the variant in public databases. We conclude that the novel variation in FGF14 is causative for SCA27 in this patient. 相似文献
64.
Idiopathic portal hypertension (IPH) is a non-cirrhotic presinuosidal portal hypertension of unknown etiology. Stenosis of smaller portal veins with portal fibrosis is a pathologic hallmark of IPH. Association of systemic sclerosis (SSc) with IPH is recognized, and similar pathologic features are reported in small portal tracts and skin of IPH and SSc, respectively. In addition, levels of transforming growth factor-β (TGF-β) and connective tissue growth factor are elevated in serum and in affected skin and portal tracts of these two diseases, suggesting that IPH share fibrogenetic mechanisms with SSc. Endothelial to mesenchymal transition (EndMT) of microvasculatures of skin could be responsible for dermal fibrosis in SSc. In IPH, EndMT of portal vein endothelium via TGF-β/Smad activation may also be involved in small portal venpathy. In IPH, enhanced expression of pSmad2 in venous endothelium of smaller portal veins was associated with reduced CD34 expression. CD34 and S100A4, and CD34 and type I collagen were colocalized to portal vein endothelium in IPH. Such myofibroblastic phenotypes may be responsible for periportal-venous deposition of collagen and compressive portal venous obliteration. These small portal venous lesions may in turn lead to portal venous insufficiency followed by subcapsular atrophy in IPH. 相似文献
65.
The effect of citrate and pyrophosphate on the stability of calcium oxalate dihydrate (COD) was studied in an aqueous solution
over 7 days. COD was precipitated from 1.0 × 10−2 mol/l calcium oxalate solution with the addition of citrate and/or pyrophosphate and separated by centrifugation immediately,
48 h and 7␣days after the precipitation. The percentage of COD in the precipitate, determined by X-ray diffraction, increased
with a rise in citrate or pyrophosphate concentration and reached ≥90% at a citrate concentration of 1.0 × 10−3 mol/l or a pyrophosphate concentration of 2.0 × 10−4 mol/l. The resulting COD was completely transformed into calcium oxalate monohydrate within 48 h when the precipitate was
composed of <90% COD. Nearly pure COD produced with pyrophosphate was stable over 7 days while that with citrate underwent
partial transformation within 48 h. An additive effect of citrate and pyrophosphate was found on the stability of COD. It
was concluded that a pyrophosphate concentration above a critical point was sufficient to prevent solution-mediated transformation
of COD, and this critical point might be lowered to the physiological range with the presence of citrate.
Received: 4 March 1997 / Accepted: 13 October 1997 相似文献
66.
67.
68.
Testicular metastasis of multiple myeloma: a case report 总被引:1,自引:0,他引:1
Y Kobayashi S Hashimoto S Tanaka S Ishiyama K Goto K Tozuka A Tokue N Shinohara 《Hinyokika kiyo. Acta urologica Japonica》1989,35(9):1617-1621
A 49-year-old man was admitted to our department with the complaint of right scrotal painless swelling in May 1986. The patient had been treated for multiple myeloma since November 1985. Right orchiectomy was performed under the diagnosis of malignant testicular tumor. The right scrotal mass was 5 x 7.5 x 3.5 cm in size. Histological diagnosis was testicular metastasis of multiple myeloma. Testicular metastasis of multiple myeloma is very rare and only 5 cases have been reported in the Japanese literature. The 6 cases including our case with testicular metastasis of multiple myeloma in Japan are reviewed. 相似文献
69.
Fifteen patients with esophageal carcinoma received the Photosensitizing dye Eosin Yellow (10 mg/kg) intravenously prior to
surgery, and their para-esophageal lymph nodes were then examined for fluorescence using a laser beam at the time of operation.
When the time interval between the injection of Eosin Yellow and the operation was 48 hours, 21 out of 22 (95.4 per cent)
metastatic lymph nodes exhibited fluorescence and 25 out of 26 (96.2 per cent) non-metastatic lymph nodes did not exhibit
fluorescence. This method proved to be invaluable for detecting metastatic lymph nodes macroscopically at the time of surgery
for esophageal carcinoma. 相似文献
70.