全文获取类型
收费全文 | 1450篇 |
免费 | 94篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 36篇 |
妇产科学 | 11篇 |
基础医学 | 174篇 |
口腔科学 | 21篇 |
临床医学 | 121篇 |
内科学 | 368篇 |
皮肤病学 | 106篇 |
神经病学 | 122篇 |
特种医学 | 75篇 |
外科学 | 172篇 |
综合类 | 9篇 |
一般理论 | 1篇 |
预防医学 | 73篇 |
眼科学 | 15篇 |
药学 | 89篇 |
中国医学 | 11篇 |
肿瘤学 | 150篇 |
出版年
2024年 | 2篇 |
2023年 | 23篇 |
2022年 | 21篇 |
2021年 | 75篇 |
2020年 | 38篇 |
2019年 | 55篇 |
2018年 | 71篇 |
2017年 | 40篇 |
2016年 | 56篇 |
2015年 | 34篇 |
2014年 | 72篇 |
2013年 | 79篇 |
2012年 | 102篇 |
2011年 | 144篇 |
2010年 | 66篇 |
2009年 | 68篇 |
2008年 | 105篇 |
2007年 | 93篇 |
2006年 | 99篇 |
2005年 | 75篇 |
2004年 | 65篇 |
2003年 | 56篇 |
2002年 | 42篇 |
2001年 | 3篇 |
2000年 | 4篇 |
1999年 | 7篇 |
1998年 | 11篇 |
1997年 | 8篇 |
1996年 | 8篇 |
1995年 | 6篇 |
1994年 | 6篇 |
1993年 | 4篇 |
1992年 | 4篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
排序方式: 共有1559条查询结果,搜索用时 164 毫秒
171.
172.
Mayumi Ikeda Tatsuto Miki Masako Atsumi Ayumi Inagaki Eri Mizuguchi Michio Meguro Daisuke Kanamori Kazuharu Nakagawa Risa Watanabe Keiko Mano Akiko Aihara Yumiko Hane Tatsuro Mutoh Koichiro Matsuo 《Geriatric nursing (New York, N.Y.)》2014
After mechanical cleaning in oral care, eliminating residual oral contaminants has an important role in preventing their aspiration, especially in individuals with weak airway protection. We examined the effectiveness of wiping the oral cavity after oral care on eliminating contaminants in 31 patients who were hospitalized in our neurology inpatient unit. The amount of bacteria on the tongue, palate, and buccal vestibule was counted before and just after oral care, after eliminating contaminants either by rinsing with water and suction or by wiping with mouth wipes, and 1 h after oral care. Oral bacteria amounts were decreased significantly by both elimination procedures after oral care. These findings suggest that wiping with mouth wipes is as effective as mouth rinsing to decrease bacteria following oral care. With a lower risk of contaminant aspiration, wiping may be a suitable alternative to rinsing, especially in dysphagic individuals. 相似文献
173.
Shingo Moriya Ayumi Murata Shinji Kimura Nobuo Inoue Hiroko Miura 《Australasian journal on ageing》2013,32(2):79-85
Aim: To determine the predictors of Japanese long‐term care insurance system (LTCI) certification. Methods: Care needs of 784 persons aged 65–84 were followed through LTCI over 5 years. Each participant's score was divided into quartiles according to handgrip strength and one‐leg standing time with eyes open. Cox proportional hazard models were conducted for the onset of certification of LTCI. Results: Over the 5‐year period 64 women (14%) and 30 men (9%) were certified. Adjusted hazard ratios for certification were significantly higher for those of the lowest groups of one‐leg standing time with eyes open at baseline than those in the highest groups, but no significance was found for handgrip strength. Other predictors were age and low social activity for women; and living alone and diabetes for men. Conclusions: One‐leg standing time with eyes open predicts the onset of care‐need certification in older people. 相似文献
174.
Yoshihito Yawata Akio Kanzaki Ayumi Yawata Hidekazu Nakanishi Mayumi Kaku 《Hematology (Amsterdam, Netherlands)》2013,18(6):399-422
This study describes the characteristic features of the incidence of hereditary red cell membrane disorders in the Japanese population based on studies of 1014 cases of these disorders from 605 kindred.Among them, there were 581 cases of hereditary spherocytosis (HS) from 303 kindred, 137 cases of hereditary elliptocytosis (HE) from 68 kindred, 104 cases of hereditary stomatocytosis (HSt) from 64 kindred, and 34 cases of protein 4.2 (P4.2) anomalies from 20 kindred, and 41 cases of membrane lipid anomalies from 27 kindred.In HS patients, eleven mutations of the band 3 (B3) gene, 15 mutations of the ankyrin gene, and three mutations of the protein 4.2 (P4.2) gene, which are pathognomonic for this disorder, were identified. Most of these mutations had not been reported and, with few exceptions, were specific to the Japanese population. P4.2 abnormalities also appear to be unique to the Japanese population. The biochemical and biophysical functions of P4.2 are associated with stabilization of the cytoskeletal network by anchoring it to integral proteins (especially B3).Biochemical and genetic analyses of the HE patients revealed one family with an α-spectrin (Sp) anomaly (HE [α1/74]) and three kindred with β-spectrin abnormalities (β-Sp Yamagata, β-Sp Tokyo, and β-Sp Nagoya) due to abnormal splicings of the β-Sp gene.On the basis of these observations, the relationship between the genotypes and phenotypes is reviewed. In addition, the morphogenesis of red cell membranes with regard to the sequential expression of these membrane proteins was also discussed. Finally, from the standpoint of gene expression, a possible role of gene methylation as an epigenetic control was proposed. 相似文献
175.
176.
Alessandro Morandi MD MPH Eduard Vasilevskis MD Pratik P. Pandharipande MD MSCI Timothy D. Girard MD MSCI Laurence M. Solberg MD Erin B. Neal PharmD Tyler Koestner MS Renee E. Torres MS Jennifer L. Thompson MPH Ayumi K. Shintani PhD MPH Jin H. Han MD MSc John F. Schnelle PhD Donna M. Fick PhD E. Wesley Ely MD MPH Sunil Kripalani MD MSc 《Journal of the American Geriatrics Society》2013,61(7):1128-1134
177.
Takumi Matsumoto Ichiro Nakamura Ayumi Miura Gen Momoyama Katsumi Ito 《Clinical rheumatology》2013,32(2):271-275
Tumor necrosis factor (TNF) antagonists have brought about a significant advancement in treatment for autoimmune diseases such as rheumatoid arthritis (RA) and Crohn’s disease; however, they are accompanied with a risk of severe adverse effects. We report the case of a 68-year-old female with a 33-year history of RA that developed multiple sclerosis (MS) during adalimumab (ADM) treatment at 22 months after the initial administration. Her first neurological symptom was mild dizziness, which progressed to severe dizziness with gait disturbance within 2 weeks. Fortunately, when she had this neurological disorder, ADM treatment was being transiently stopped because she was in the perioperative period. Repeated magnetic resonance imaging examinations revealed multiple demyelinating lesions in her brain, leading to the diagnosis of MS. The patient completely recovered spontaneously from the symptoms in several days. A review of the literature revealed another 15 cases of MS associated with anti-TNF-α treatment, emphasizing the importance of detecting neurological symptoms and discontinuing the anti-TNF-α therapy. 相似文献
178.
Naoto Tomita Hirotaka Takasaki Kazuho Miyashita Shin Fujisawa Eriko Ogusa Shiro Matsuura Kumiko Kishimoto Ayumi Numata Atsuko Fujita Rika Ohshima Hideyuki Kuwabara Maki Hagihara Chizuko Hashimoto Sachiya Takemura Hideyuki Koharazawa Etsuko Yamazaki Katsumichi Fujimaki Jun Taguchi Rika Sakai Yoshiaki Ishigatsubo 《British journal of haematology》2013,161(3):383-388
Long‐term observation has identified a pattern of continuing relapse in limited stage diffuse large B‐cell lymphoma (DLBCL) treated by three cycles of R‐CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) plus involved‐field irradiation. We retrospectively analysed 190 untreated patients with limited stage DLBCL treated by R‐CHOP alone. All the patients were scheduled to undergo primary therapy with six cycles of full‐dose R‐CHOP. Cases with a dose reduction of more than 20% were excluded from the study. Additional local irradiation was allowed in patients with partial response (PR). Five patients received additional local irradiation after PR at the end of the R‐CHOP therapy. The median observation period was 52 months. Median age at diagnosis was 63 years. The responses to therapy were 180 complete responses, eight PR, and two progression of disease (PD). The 5‐year progression‐free survival and 5‐year overall survival rates were 84% and 90%, respectively, both in plateau. During the observation period, 29 patients experienced PD. The progression sites were the primary sites in 15 patients, outside the primary sites in 10, and undetermined in four patients. These results suggest that the ‘standard’ strategy of three cycles of R‐CHOP followed by involved‐field radiotherapy for limited stage DLBCL could be effectively replaced by six cycles of R‐CHOP alone. 相似文献
179.
Takeshi Baba Yasuko Amasaki Midori Soda Ayumi Hida Misa Imaizumi Shinichiro Ichimaru Eiji Nakashima Shinji Seto Katsusuke Yano Masazumi Akahoshi 《Hypertension research》2007,30(9):823-829
Relationships between fatty liver and coronary heart disease (CHD) and stroke risk remain ill defined. We investigated whether fatty liver is a predictor of CHD and stroke risk. Until December 2000 we followed 2,024 atomic bomb survivors (775 men: 62.0 +/- 9.9 years old; 1,249 women: 63.2 +/- 8.4 years old) who had basic examinations between November 1990 and October 1992 for clinical and laboratory CHD risk factors and fatty liver and who were initially free of CHD and stroke. Forty-nine cases of CHD and 84 cases of stroke were observed. At the time of the baseline examinations, significant clinical associations were found between fatty liver and obesity (p<0.001), hypertension (p<0.001), dyslipidemia (p<0.001), and glucose intolerance (p<0.001). A slight but nonsignificant association was found between fatty liver and hyperuricemia (p=0.07) as well. By using multiple Cox regression analyses, age (relative risk [RR] 1.05, 95% confidence interval [CI] 1.01-1.08), smoking (RR 2.20, 95% CI 1.02-4.74), hyperuricemia (RR 2.30, 95% CI 1.08-4.89), and fatty liver (RR 2.53, 95% CI 1.06-6.06) were shown to be significant predictors of CHD, whereas age (RR 1.08, 95% CI 1.06-1.10), smoking (RR 2.06, 95% CI 1.14-3.72), and hypertension (RR 2.14, 95% CI 1.38-3.30) predicted stroke risk. Fatty liver, which clusters clinical and laboratory CHD risk factors, is an independent predictor of CHD, but not of stroke. Fatty liver should be followed as a feature of metabolic syndrome, with the aim of preventing CHD. 相似文献
180.