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排序方式: 共有72条查询结果,搜索用时 31 毫秒
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Miwako Narita Norihiro Watanabe Akie Yamahira Shigeo Hashimoto Nozomi Tochiki Anri Saitoh Masami Kaji Takeshi Nakamura Tatsuo Furukawa Ken Toba Ichiro Fuse Yoshifusa Aizawa Masuhiro Takahashi 《Leukemia research》2009,33(9):1224-1232
We established a plasmacytoid dendritic cell (pDC) line (PMDC05) from leukemia cells of pDC leukemia. PMDC05 cells were positive for CD4, CD56, CD33, HLA-DR, CD123 (IL-3Rα) and CD86 in the absence of lineage markers. mRNA of TLR1, TLR2, TLR4, TLR7 and TLR9 was clearly expressed and among these TLRs, TLR7 was prominent. Production of IFN-α and IL-12 in PMDC05 was enhanced by the stimulation with CpG-A and LPS, respectively. PMDC05 possessed a considerable antigen presenting ability, which was enhanced by culturing with IL3, influenza virus or LPS. PMDC05 could be a useful tool for investigating the pathophysiology of pDCL. 相似文献
34.
Wakabayashi H Nakajima K Fukuoka M Inaki A Nakamura A Kayano D Kinuya S 《Annals of nuclear medicine》2011,25(9):609-615
Objective
This study aims to determine whether a 131I double-phase whole body scan (WBS) and SPECT-CT images have added value over a single-phase WBS image in identifying benign and malignant lesions in patients with well-differentiated thyroid cancer (DTC) at their first radioactive iodine (RAI) treatment. 相似文献35.
To evaluate the prognostic value of delayed myelination at the onset of cryptogenic West syndrome, the relationship between the seizure or developmental outcome and myelination was examined. Cranial magnetic resonance imaging studies were performed in nine cryptogenic cases. Infantile spasms were controlled in all patients, but three cases showed a mild developmental delay at 2 years after onset. Delayed myelination was observed in three cases (33.3%) on T(1)-weighted images and in two cases (22.2%) on T(2)-weighted images. In the present study, neither the seizure outcome nor developmental status was positively correlated with the existence of delayed myelination at the onset of cryptogenic West syndrome. 相似文献
36.
Serum immunoreactive interleukin-6 and C-reactive protein levels in patients with multiple myeloma at diagnosis 总被引:1,自引:0,他引:1
Anri Tienhaara Kari Pulkki Kari Mattila Kerttu Irjala Tarja-Terttu Pelliniemi 《British journal of haematology》1994,86(2):391-393
Summary Serum bioactive but not immunoreactive interleukin-6 (IL-6), and serum C-reactive protein (CRP), have been reported to be of prognostic significance in multiple myeloma (MM). We measured serum immunoreactive IL-6 by a sensitive enzyme-linked immunosorbent assay in 30 MM patients at diagnosis. In 30% of the patients serum immuno-reactive IL-6 exceeded the upper reference limit. The concentrations of CRP and IL-6 showed a linear association. Logarithmically transformed IL-6, CRP and β2 -microglobulin were significant variables by univariate survival analysis: by multivariate analysis CRP was a slightly stronger prognostic factor than IL-6 and the only one of independent prognostic significance. 相似文献
37.
Wakabayashi Hiroshi Kayano Daiki Inaki Anri Araki Raita Kuroda Rie Ikawa Yasuhiro Fujiki Toshihiro Akatani Norihito Yamase Takafumi Watanabe Satoru Hiromasa Tomo Kunita Yuji Mori Hiroshi Saito Shintaro Nishimura Ryosei Wada Taizo Kinuya Seigo 《Annals of nuclear medicine》2020,34(11):840-846
Annals of Nuclear Medicine - Children with relapsed neuroblastoma have a poor prognosis despite modern multimodality therapy. Novel and more effective therapeutic strategies are required for... 相似文献
38.
Kari Pulkki Tarja-Terttu Pelliniemi Allan Rajamäki Anri Tienhaara Markku Laakso & Reino Lahtinen 《British journal of haematology》1996,92(2):370-374
Interleukin-6 (IL-6) is a major growth factor for the clonal malignant plasma cells in multiple myeloma (MM). The effect of IL-6 may be enhanced by soluble IL-6 receptor (sIL-6R). As there is a clinical need for improved stratification of MM patients at diagnosis, we have studied the role of sIL-6R as a prognostic marker in 207 newly diagnosed MM patients. Serum sIL-6R concentration was above the upper reference limit in 47% of the patients at diagnosis. The concentrations of sIL-6R and two other prognostic factors, IL-6 and β-2 microglobulin (β2M), were all significantly higher in the patients who died within 3 years compared with those who survived. However, serum sIL-6R did not show linear correlation with IL-6 or β2M levels. In univariate logistic regression analysis sIL-6R was a significant predictor of 3-year mortality. Kaplan-Meier analysis showed that raised levels of sIL-6R were associated with shorter survival. When the patients were stratified into four groups according to their serum IL-6 and sIL-6R levels, the patients with normal serum levels of both parameters had clear survival benefit. As β2M was the most powerful prognostic factor in the multivariate analysis, the patients were also stratified according to their serum β2M and sIL-6R levels. The patients with raised levels of both β2M and sIL-6R had shorter survival than the patients in the other three groups. Thus, measurement of these parameters at diagnosis would help to stratify MM patients. 相似文献
39.
Dosimetry of spatial dose distribution of ionizing radiation in tissue equivalent materials is particularly important for cancer radiotherapy. Here, we describe a radio-fluorogenic gel-based dosimeter that has achieved 16 times higher sensitivity by incorporating surfactants and halogenides. The gel dosimeters were prepared from dihydrorhodamine 123 (DHR123) and small amounts of nano-sized clay and a radiosensitizer. By comprehensively changing the type of additives for the sensitizer (three surfactants: Triton X-100, sodium dodecyl sulfate (SDS) and cetyltrimethylammonium bromide, and three halogenides: trichloroacetic acid, tribromoacetic acid and 2,2,2-trichloroethanol), the increase in sensitivity can be explained by an increase in relative fluorescence quantum yield and an increase in radiation chemical yield. These highly sensitive gel dosimeters also show dose rate independent sensitivity under irradiation at 0.64 and 0.77 Gy min−1 using a 6 MV X-ray therapeutic beam from the medical linac.Dosimetry of spatial dose distribution of ionizing radiation in tissue equivalent materials using high sensitive radio-fluorogenic gel dosimeter using DHR123 with sensitizer. (Radiation therapy planning image courtesy of Varian Medical Systems, Inc. All rights reserved.) 相似文献
40.
Minamitake Anri Murakami Ryuji Shiraishi Shinya Yoshida Ryoji Sakata Junki Hirosue Akiyuki Kawahara Kenta Yamana Keisuke Nakayama Hideki Kitajima Mika Sakamoto Fumi 《Oral Radiology》2022,38(3):438-442
Oral Radiology - This study aimed to assess the role of preoperative 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) for predicting late neck metastasis in... 相似文献