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101.
Further experience with radiation therapy and concomitant intravenous chemotherapy in advanced carcinoma of the lower female genital tract 总被引:4,自引:1,他引:3
William S. Roberts M.D. Mitchel S. Hoffman M.D. John J. Kavanagh M.D. James V. Fiorica M.D. Harvey Greenberg M.D. Michael A. Finan M.D. Denis Cavanagh M.D. 《Gynecologic oncology》1991,43(3):233-236
Sixty-seven patients with advanced carcinoma of the lower female genital tract (cervix, vagina, and vulva) were treated with radiation and concomitant intravenous cisplatin and/or 5-fluorouracil. Fifty-seven patients (85%) responded completely clinically. Thirty-five (61%) complete responders recurred with a median time to recurrence of 6 months. Twenty-six of the thirty-five patients who recurred had some component of local failure. The 22 complete responders who have not recurred have been followed a median of 13 months. Acute toxicity was minimal, with only 6 patients requiring interruption of therapy. Nine (13%) patients developed severe late complications and eight required surgery. The actuarial 5-year survival is 22%. This treatment regimen is disappointing in terms of both survival and local control. 相似文献
102.
103.
Philippe-Olivier Harvey Martin Lepage Ashok Malla 《Revue canadienne de psychiatrie》2007,52(7):464-472
OBJECTIVE: To assess the effectiveness of enriched intervention (EI) on symptomatic and functional outcomes, compared with standard care (SC). METHOD: Studies were retrieved from search engines and, using a metaanalytic approach, we compared El trials with SC trials. Eleven EI sample trials (1053 patients) and 6 SC sample trials (500 patients), totalling data from 1553 patients (69% male), were examined. We calculated the effect sizes (ESs) of both symptomatic and functional improvement over a follow-up period of about 1 year. RESULTS: Significant differences between El and SC were observed at follow-up for the improvement of both positive and negative symptoms, respectively: positive, EI = -1.54 (95%CI, -1.63 to -1.45 ) and SC = -1.07 (95%CI, -1.19 to -0.94) (Qbetween = 40.3, df 1, P < 0.001); negative, EI= -0.44 (95%CI, -0.53 to -0.35) and SC = -0.18 (95%Cl, -0.31 to -0.05) (Qbetween = 10.6, df 1, P < 0.01). We also observed a significant difference between the El and the SC groups for functional improvement over the follow-up period with mean EI = 1.11 (95%CI, 0.99 to 1.23) and SC = 0.63 (95%CI, 0.49 to 0.77) (Qbetween = 24.5, df 1, P < 0.001). CONCLUSIONS: There is now quantitative evidence across multiple studies and sites to indicate that Els for patients with recent-onset psychosis are significantly more effective than SC for symptomatic and functional improvement over a period of about 1 year. 相似文献
104.
105.
Ann Lecluyse 《The European journal of health economics》2007,8(3):237-243
This paper provides new evidence on the degree of income-related inequality in self-assessed health in Belgium. First of all,
we combine the time dimension, which has been shown to be very important in the analysis of inequality, and the use of the
recently developed interval regression approach to transform a categorical health variable in a continuous one. Second, we
measure how the long-run inequality differs from the short-run inequality. Finally, we decompose this health-related income
mobility index as well as the long-run concentration index (CI) itself into its contributors. Using data from the panel survey
of Belgian households (1994–2002), we find that health is pro-rich distributed and that its inequality is underestimated by
9.45% when neglecting the dynamics of individuals over time. Income, education, job status and age are the most important
contributors in the CI and the difference between the short-run and long-run inequality.
相似文献
106.
107.
108.
109.
Ann Goetting 《The journal of primary prevention》1994,14(3):169-186
This paper examines delinquency as it relates to family influences. 相似文献
110.
Dr. Harvey I. Pass MD Karen Kranda RN Barbara K. Temeck MD Irwin Feuerstein MD Seth M. Steinberg PhD 《Annals of surgical oncology》1997,4(3):215-222
Background: We analyzed morbidity and mortality, sites of recurrence, and possible prognostic factors in 95 (78 male, 17 female) patients
with MPM on phase I–III trials since 1990. A debulking resection to a requisite, residual tumor thickness of ≤ 5 mm was required
for inclusion.
Methods: Preoperative tumor volumes were determined by three-dimensional reconstruction of chest computerized tomograms. Pleurectomy
(n=39) or extrapleural pneumonectomy (EPP; n=39) was performed. Seventeen patients could not be debulked. Preoperative EPP
platelet counts (404,000) and mean tumor volume (491 cm3) were greater than that seen for pleurectomy (344,000, 114 cm3).
Results: Median survival for all patients was 11.2 months, with that for pleurectomy 14.5 months, that for EPP 9.4 months, and that
for unresectable patients 5.0 months. Arrhythmia (n=14; 15%) was the most common complication, and there were two deaths related
to surgery (2.0%). Tumor volume of >100 ml, biphasic histology, male sex, and elevated platelet count were associated with
decreased survival (p<0.05). Both EPP and pleurectomy had equivalent recurrence rates (27 of 39 [69%] and 31 of 39 [79%],
respectively); however, 17 of 27 EPP recurrences as opposed to 28 of 31 pleurectomy recurrences were locoregional (p2=0.013).
Conclusions: Debulking resections for MPM can be performed with low operative mortality. Size and platelet count are important preoperative
prognostic parameters for MPM. Patients with poor prognostic indicators should probably enter nonsurgical, innovative trials
where toxicity or response to therapy can be evaluated.
Presented at the 49th Annual Cancer Symposium of The Society of Surgical Oncology, Atlanta, Georgia, March 21–24, 1996. 相似文献