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101.
Anke Steinmetz Andreas Stang Malte Kornhuber Marc Röllinghoff Karl-Stefan Delank Eckart Altenmüller 《International archives of occupational and environmental health》2014,87(7):783-792
Objectives
Data concerning embouchure problems in professional brass players are scarce. Embouchure problems can potentially lead to focal dystonia. The aim of this study was to investigate the frequency of distinct embouchure problems in professional brass players. Furthermore, the frequency of “cramping”, a distinct symptom of embouchure dystonia, was evaluated in the context of established embouchure dystonia risk factors.Methods
Five hundred and eighty-five professional brass players participated in a cross-sectional study concerning embouchure problems. A self-administered questionnaire was developed to evaluate embouchure fatigue, embouchure disorders and their consequences. To study the association between risk factors and cramping (a symptom of embouchure dystonia), a log-binomial regression analysis was conducted, enabling estimation of prevalence ratios (PR) and 95 % confidence intervals (95 % CI).Results
Thirty percent (95 % CI 25.9–33.3) reported embouchure fatigue. The relative frequency of embouchure disorders was 59 % (95 % CI 54.6–63.6), with 26 % (95 % CI 22.4–29.5) reporting embouchure cramping. Embouchure disorders resulted in sick leave in 16 % (95 % CI 12.7–20.6). Female brass players (PR 2.0, 95 % CI 0.98–3.98) and musicians with a prior change in their embouchure (PR 2.4, 95 % CI 1.38–4.05) or breathing technique (PR 2.2, 95 % CI 1.25–3.72) and musicians with embouchure fatigue (PR 1.9, 95 % CI 1.18–2.93) presented more frequently with embouchure cramping than musicians with other or without risk factors.Conclusion
This study shows a high relative frequency of embouchure problems in professional brass players. Given that embouchure dystonia is often preceded by embouchure problems, these findings may assist in gaining further insight into the characteristics of embouchure dystonia and the development of preventive strategies. 相似文献102.
Geert Vandeweyer Céline Helsmoortel Anke Van Dijck Anneke T. Vulto-van Silfhout Bradley P. Coe Raphael Bernier Jennifer Gerdts Liesbeth Rooms Jenneke van den Ende Madhura Bakshi Meredith Wilson Ann Nordgren Laura G. Hendon Omar A. Abdulrahman Corrado Romano Bert B.A. de Vries Tjitske Kleefstra Evan E. Eichler Nathalie Van der Aa R. Frank Kooy 《American journal of medical genetics. Part C, Seminars in medical genetics》2014,166(3):315-326
103.
Anke Korfage Gerry M. RaghoebarJames J.R. Huddleston Slater Jan L.N. RoodenburgMax J.H. Witjes Arjan VissinkHarry Reintsema 《The British journal of oral & maxillofacial surgery》2014
We aimed to assess oral functioning, patients’ satisfaction, condition of peri-implant tissues, and survival of implants up to 14 years after their insertion in patients with oral cancer who had had mandibular overdentures placed over primary implants. Endosseous dental implants were inserted prospectively in the interforaminal region of the mandible during resection of the tumour in 164/180 patients with oral cancer. All 58 patients were evaluated by questionnaires and clinical assessments during a final assessment in 2012. Implant-retained mandibular overdentures were inserted, and prosthetic rehabilitation and oral functioning were not associated with primary site or stage of the tumour, number or type of implants inserted, or the type of reconstruction. Over time the peri-implant mucosa was usually free of inflammation. More implants were lost in patients treated by radiotherapy (27/318, 8.5%) than in those not so treated (1/206, 0.5%). Patients who had been treated by irradiation reported more problems in oral functioning and less satisfaction than those who had not. Patients with an implant-retained mandibular overdenture reported fewer problems in oral functioning than patients without an overdenture. 相似文献
104.
105.
Stefano Barco Stefanie Sollfrank Alice Trinchero Anke Adenaeuer Hassan Abolghasemi Laura Conti Friederike Huser Johanna A. Kremer Hovinga Karl J. Lackner Felicia Loewecke Erwin Miloni Nader Vazifeh Shiran Luigi Tomao Walter A. Wuillemin Barbara Zieger Bernhard Lmmle Heidi Rossmann 《Journal of thrombosis and haemostasis》2020,18(7):1598-1617
106.
Maximilian Pistor Helly Hammer Anke Salmen Robert Hoepner Christoph Friedli 《CNS Neuroscience & Therapeutics》2022,28(5):792
Survival analysis of reaching EDSS ≥4.0 based on RoAD score ≥4 (dashed line) and <4 (solid line) by Cox regression analysis. (A) Unadjusted regression analysis. (B) Regression controlled for sex and immunotherapy groups, and the trajectory of treatment changes during follow‐up. 相似文献
107.
Bianca Raffaelli Maria Terhart Jasper Mecklenburg Lars Neeb Lucas Hendrik Overeem Anke Siebert Maureen Steinicke Uwe Reuter 《The journal of headache and pain》2022,23(1)
BackgroundMigraine frequency increases after the cessation of successful preventive treatment with CGRP(-receptor) monoclonal antibodies (mAbs). In this study, we aimed to evaluate the course of migraine after treatment resumption.MethodsPatients with migraine, who started treatment with the same CGRP(-R) mAb after a three-month drug holiday were included in this analysis. We collected headache data at four prospective visits: 1) during the four weeks before the initial mAb treatment (baseline); 2) during the four weeks before the last mAb injection; 3) in weeks 13–16 of the drug holiday; 4) in weeks 9–12 after treatment restart. Outcomes were the changes in monthly migraine days (MMD), monthly headache days (MHD), monthly days with acute medication use (AMD) and Headache Impact Test-6 (HIT-6) scores across the observation period.ResultsThis study included 39 patients (erenumab n = 16; galcanezumab/ fremanezumab n = 23). MMD decreased from 12.3 ± 6.3 at the end of the drug holiday to 7.8 ± 5.5 three months after treatment restart (p = 0.001). The improvement after treatment resumption was similar to the response in the initial treatment period (baseline: 12.3 ± 6.3 MMD vs. 7.5 ± 5.2 MMD before treatment interruption). MHD and AMD showed a significant improvement after treatment restart. HIT-6 scores decreased, indicating a diminished impact of headache on everyday life.ConclusionsReinitiation of treatment with CGRP(-R) mAbs after a drug holiday leads to a significant reduction of migraine frequency and medication use as well as improvement in quality of life. 相似文献
108.
Paclitaxel and cyclosporine A show supra-additive antiproliferative effects on smooth muscle cells by activation of protein kinase C 总被引:4,自引:0,他引:4
Sindermann JR Skaletz-Rorowski A Bartels A Hohage H Plenz G Schmidt A Breithardt G 《Basic research in cardiology》2002,97(2):125-131
We intended to establish a pharmacologic concept of synergistic antiproliferative effects on smooth muscle cells (SMC) by
using paclitaxel and cyclosporine A at clinically applicable doses. Coronary SMC were incubated with paclitaxel and cyclosporine
A at concentrations of 10 – 20 nmol/L and 83 – 415 nmol/L, respectively. Antiproliferative effects were assessed by cell counts,
[3H]thymidine incorporation and cell cycle analysis. In addition, apoptosis was studied by cytoplasmic histone-associated DNA
fragments and in vitro protein kinase C activity (PKC) was determined by immunoassay. We found paclitaxel and cyclosporine A to exert a highly supra-additive
antiproliferative effect on SMC with significant reductions of cell counts (p < 0.01) and [3H]thymidine incorporation (p < 0.05). SMC were found to be arrested at the G2/M transition. This antiproliferative effect
was observed in the absence of DNA fragmentation above values obtained for single compound treatment, which had virtually
no impact on cell proliferation. DNA fragmentation started to increase at a drug combination comprising paclitaxel at the
higher dose of 20 nmol/L. Under the treatment with both paclitaxel and cyclosporine A, PKC activity showed a 1.8-fold increase
(p < 0.05) compared with untreated controls. In conclusion, PKC mediates supra-additive antiproliferative effects of paclitaxel
and cyclosporine A on SMC. The data demonstrate a highly efficient pharmacologic concept for the inhibition of SMC proliferation.
Further studies are needed to test this concept under in vivo conditions for the prevention of restenosis or transplant vasculopathy by systemic application of cyclosporine A – when already
applied for immunosuppressive purposes – and local delivery of paclitaxel.
Received: 28 August 2001, Returned for revision: 25 September 2001, Revision received: 20 November 2001, Accepted: 4 December
2001 相似文献
109.
Background Intestinal obstruction in pregnancy is rare. Symptoms are often unspecific and a high level of suspicion is essential for
early diagnosis. Fetal and maternal mortality rates are higher during pregnancy due to delay in diagnosis.
Case A 31-year-old primigravida with a history of abdominal surgery was admitted because of worsening abdominal pain, abdominal
distension and elevated pancreatic enzymes. Ultrasound showed dilated small bowel loops. Explorative laparotomy revealed a
small bowel obstruction with partial bowel necrosis caused by a single adhesion. A jejuno-jejunostomy was performed. Five
days later, she developed peritonitis. A secondary laparotomy and caesarean section were done.
Conclusion In spite of timely diagnosis and prompt surgical intervention, our case was still complicated by peritonitis and early delivery.
This underlines the necessity of immediate clinical suspicion. Small bowel obstruction should be considered in differential
diagnosis of pregnant patients with a history of abdominal surgery. 相似文献
110.
Anke de Haan Markus A. Landolt Eiko I. Fried Kristian Kleinke Eva Alisic Richard Bryant Karen Salmon Sue-Huei Chen Shu-Tsen Liu Tim Dalgleish Anna McKinnon Alice Alberici Jade Claxton Julia Diehle Ramón Lindauer Carlijn de Roos Sarah L. Halligan Rachel Hiller Christian H. Kristensen Beatriz O.M. Lobo Nicole M. Volkmann Meghan Marsac Lamia Barakat Nancy Kassam-Adams Reginald D.V. Nixon Susan Hogan Raija-Leena Punamäki Esa Palosaari Elizabeth Schilpzand Rowena Conroy Patrick Smith William Yule Richard Meiser-Stedman 《Journal of child psychology and psychiatry, and allied disciplines》2020,61(1):77-87