全文获取类型
收费全文 | 38844篇 |
免费 | 2801篇 |
国内免费 | 161篇 |
专业分类
耳鼻咽喉 | 228篇 |
儿科学 | 1115篇 |
妇产科学 | 1051篇 |
基础医学 | 6046篇 |
口腔科学 | 517篇 |
临床医学 | 4367篇 |
内科学 | 8829篇 |
皮肤病学 | 617篇 |
神经病学 | 3841篇 |
特种医学 | 929篇 |
外国民族医学 | 1篇 |
外科学 | 4564篇 |
综合类 | 271篇 |
一般理论 | 35篇 |
预防医学 | 3454篇 |
眼科学 | 379篇 |
药学 | 2526篇 |
中国医学 | 64篇 |
肿瘤学 | 2972篇 |
出版年
2023年 | 241篇 |
2022年 | 410篇 |
2021年 | 980篇 |
2020年 | 635篇 |
2019年 | 1007篇 |
2018年 | 1105篇 |
2017年 | 778篇 |
2016年 | 914篇 |
2015年 | 1066篇 |
2014年 | 1373篇 |
2013年 | 1868篇 |
2012年 | 2927篇 |
2011年 | 3057篇 |
2010年 | 1745篇 |
2009年 | 1559篇 |
2008年 | 2633篇 |
2007年 | 2691篇 |
2006年 | 2661篇 |
2005年 | 2605篇 |
2004年 | 2394篇 |
2003年 | 2218篇 |
2002年 | 2080篇 |
2001年 | 307篇 |
2000年 | 230篇 |
1999年 | 327篇 |
1998年 | 448篇 |
1997年 | 372篇 |
1996年 | 320篇 |
1995年 | 314篇 |
1994年 | 249篇 |
1993年 | 251篇 |
1992年 | 186篇 |
1991年 | 148篇 |
1990年 | 130篇 |
1989年 | 132篇 |
1988年 | 113篇 |
1987年 | 87篇 |
1986年 | 102篇 |
1985年 | 77篇 |
1984年 | 109篇 |
1983年 | 82篇 |
1982年 | 95篇 |
1981年 | 112篇 |
1980年 | 63篇 |
1979年 | 54篇 |
1978年 | 55篇 |
1977年 | 37篇 |
1976年 | 44篇 |
1975年 | 33篇 |
1973年 | 33篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
Ennio Del Giudice Maria Cristina Bianchi Michela Tosetti Andrea Varrone Alfonso Romano Angela Francesca Crisanti Luigi Titomanlio Floriana Imperati 《Epileptic Disord》2006,8(4):289-293
Patients with Taylor-type focal cortical dysplasia (TTFCD) generally present with medically intractable epilepsy and impaired neurological and/or intellectual functioning. Surgery usually proves to be the only treatment approach leading to control of seizures. We describe a 17-year-old girl with TTFCD who exhibited a very long period of seizure remission. Combined clinical and neuroimaging findings were compatible with a diagnosis of a balloon cell-subtype TTFCD. As for the clinical course, partial motor seizures began at one year of age and ceased at five: our patient has had no seizure recurrence over a 12-year-follow-up. Moreover, throughout the 15-year follow-up, neurological examinations and cognitive abilities always remained within normal limits. Neuropsychological assessment clearly showed no impairments in executive functions: planning abilities, working memory, attention and impulse control, or constructive aspects of motor coordination. The predominant deficits pertained to verbal abilities in the context of borderline intellectual performances. To our knowledge, this case report documents the longest duration of seizure remission in a patient with TTFCD, thus emphasizing the possible benign course of such dysplastic lesions which usually have a poor prognosis, leading to early surgical treatment. 相似文献
82.
83.
84.
85.
86.
Susan D. Ross M.D. Angela DiGeorge B.S. Janet E. Connelly B.S. Gregory W. Whiting B.S Neil McDonnell Pharm.D. 《Pharmacotherapy》1998,18(6):1290-1297
We performed a literature search for all clinical studies reporting outcomes in patients with the acquired immunodeficiency syndrome (AIDS) receiving granulocyte-macrophage colony-stimulating factor (GM-CSF) for any indication. Safety outcomes included human immunodeficiency virus replication, immune status, and frequency of opportunistic infections and neoplasms. Data were synthesized qualitatively. We identified 22 studies (274 patients): 12 addressed AIDS neutropenia, 8 AIDS cancer therapy, and 2 opportunistic infections. Viral burden was assessed by serum p24Ag in 15 studies. Nine reported no change in levels, three net decreases, and three net increases. All studies showing net increases involved patients receiving GM-CSF without a concurrent antiretroviral. The CD4 counts were unchanged in 5 studies, increased in 3, and not reported in 14. The incidence of neoplasms or new opportunistic infections was low. The literature suggests no increased risk of viral replication or clinical deterioration in patients with AIDS who take GM-CSF concurrently with zidovudine. 相似文献
87.
Summary: We have developed a novel experimental model of cancer immunity in the frog, Xenopus , which may provide a useful alternative to murine tumor models and a way to assess whether the control of tumor development is a fundamental function of the immune system of vertebrates. In Xenoptis , tumor immunity can be studied in two developmentally distinct immune systems. The larval immune system reflects characteristics of an ancestral system that appears to function without classical MHC class I antigen presentation and an efficient effector mechanism. The adult system appears more highly evolved in that it is remarkably similar to that of mammals and is able to generate a potent antitumor response. This amphibian model also provides a unique system with which to investigate a postulated role of heat shock proteins as components of an ancestral system of antigen presentation and/or immune surveillance that predates the antigen presentation pathway that exclusively involves MHC molecules. 相似文献
88.
Jean-Luc Garrigue Philippe Catroux Jacques Leclaire 《Clinical reviews in allergy & immunology》1995,13(3):189-200
Conclusion The search for a link between cellular and molecular events involved in delayed-type CHS reactions and the early molecular
activation of xenobiotics is a new field of research. It should largely contribute to the debate on the best way forward for
predictive toxicology in general. 相似文献
89.
Angela Ford 《Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid》1996,28(1-3):121-124
In an attempt to determine the risks for and kinds of dementia most prevalent among the African American population, the Alzheimer's Disease Research Center at the University of Pittsburgh developed a community satellite program specifically targeting the African American and historically medically underserved communities in Allegheny County, PA. The primary mission of the Alzheimer Outreach Center (AOC) was to increase the awareness of AD among the targeted population. The number of nonwhite patients participating in the studies at ADRC increased from 2 to 16% in the first year of the program. In May 1995, the AOC became a permanent ADRC program. 相似文献
90.