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11.
Honn KV Aref A Chen YQ Cher ML Crissman JD Forman JD Gao X Grignon D Hussain M Porter AT Pontes JE Powell I Redman B Sakr W Severson R Tang DG Wood DP 《Pathology oncology research : POR》1996,2(1-2):98-109
Rates of prostate cancer (PCa) have increased so dramatically over the last decade that the age adjusted incidence rate for PCa is now greater than that any other cancer among men in the United States. This review, published as a three part series, provides a state-of-art assessment of the PCa problem in its divergent aspects.Part 1 covers epidemiology, incidence and progression. Several epidemiological studies have demostrated that first degree male relatives of men with PCa are at increased risk of developing the disease. Familial and genetic factors as well as medical, anthropometric, dietary, hormonal and occupational factors involved in PCa are discussed. Postmortem examination of the prostate in men without evidence of PCa documented a high frequency of adenocarcinoma. Latent disease occurred as early as the second decade of life. Although there is no significant difference in incidence between Caucasian and African-American males, high grade prostatic intraepithelial neoplasia (HGPIN) is higher in the latter group. While dietary fat, androgens and certain environmental factors may be determinants for PCa, the exact mechanism of tumorigenesis is still relatively unknown. The current thinking of the role of genomic instability, chromosomal alterations, tumor suppressor genes and the androgen receptor are explored. 相似文献
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众所周知,有47%的不育是由于精子异常引起的。尽管医学发展迅速,仍有40%的不育患者存在病因不明的精液异常使临床疗效受限。另一方面,有报道显示中医疗法治疗精索静脉曲张、前列腺炎和精子异常疗效满意。我们尝试通过盲法对照试验观察针灸对精子异常不育患者的精子浓度、形态和活力是否有改善作用。 相似文献
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Lleonart R Riego E Saínz de la Peña MV Bacallao K Amaro F Santiesteban M Blanco M Currenti H Puentes A Rolo F Herrera L de la Fuente J 《International journal of legal medicine》2000,113(2):98-101
We report the positive identification of several members of the guerrillas led by Ernesto “Che” Guevara on the 1960 s in
Bolivia by means of DNA fingerprinting. Successful DNA typing of both short tandem repeat loci and the hypervariable region
of the human mitochondrial DNA was achieved after extracting total DNA from bones obtained from two burial sites. Given the
size of the Cuban database for the STR allele frequencies, a conservative approach was followed to estimate the statistical
significance of the genetic evidence. The estimated probabilities of paternity for the two cases in which the paternity logic
was applied were higher than 99%. One case was analyzed using mitochondrial DNA and could not be excluded from the identity
proposed by the forensic anthropology team. A fourth case was identified by exclusion, on the basis of the positive identification
of the other remains, the historical and other anthropological evidence.
Received: 19 January 1999 / Received in revised form: 15 April 1999 相似文献
14.
Thiago A Teixeira Yasmin C Oliveira Felipe S Bernardes Esper G Kallas Amaro N Duarte-Neto Sandro C Esteves Jo?l R Drevet Jorge Hallak 《Asian journal of andrology》2021,(4):335-347
Viral infections have haunted humankind since times immemorial.Overpopulation,globalization,and extensive deforestation have created an ideal environment for a ... 相似文献
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