全文获取类型
收费全文 | 20277篇 |
免费 | 1644篇 |
国内免费 | 38篇 |
专业分类
耳鼻咽喉 | 136篇 |
儿科学 | 789篇 |
妇产科学 | 773篇 |
基础医学 | 2661篇 |
口腔科学 | 256篇 |
临床医学 | 2814篇 |
内科学 | 3587篇 |
皮肤病学 | 399篇 |
神经病学 | 1977篇 |
特种医学 | 412篇 |
外国民族医学 | 1篇 |
外科学 | 2210篇 |
综合类 | 340篇 |
一般理论 | 30篇 |
预防医学 | 2793篇 |
眼科学 | 336篇 |
药学 | 1256篇 |
1篇 | |
中国医学 | 33篇 |
肿瘤学 | 1155篇 |
出版年
2023年 | 179篇 |
2022年 | 263篇 |
2021年 | 546篇 |
2020年 | 344篇 |
2019年 | 581篇 |
2018年 | 679篇 |
2017年 | 430篇 |
2016年 | 526篇 |
2015年 | 581篇 |
2014年 | 754篇 |
2013年 | 978篇 |
2012年 | 1545篇 |
2011年 | 1583篇 |
2010年 | 806篇 |
2009年 | 725篇 |
2008年 | 1266篇 |
2007年 | 1343篇 |
2006年 | 1238篇 |
2005年 | 1144篇 |
2004年 | 1084篇 |
2003年 | 976篇 |
2002年 | 870篇 |
2001年 | 343篇 |
2000年 | 298篇 |
1999年 | 308篇 |
1998年 | 181篇 |
1997年 | 147篇 |
1996年 | 131篇 |
1995年 | 118篇 |
1994年 | 111篇 |
1993年 | 97篇 |
1992年 | 182篇 |
1991年 | 156篇 |
1990年 | 134篇 |
1989年 | 125篇 |
1988年 | 146篇 |
1987年 | 120篇 |
1986年 | 130篇 |
1985年 | 84篇 |
1984年 | 66篇 |
1983年 | 59篇 |
1982年 | 49篇 |
1981年 | 55篇 |
1980年 | 34篇 |
1979年 | 52篇 |
1978年 | 31篇 |
1977年 | 30篇 |
1976年 | 35篇 |
1974年 | 46篇 |
1973年 | 34篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Genetic 3′UTR variation is associated with human pigmentation characteristics and sensitivity to sunlight
下载免费PDF全文
![点击此处可从《Experimental dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Barbara Hernando Maria Peña‐Chilet Maider Ibarrola‐Villava Manuel Martin‐Gonzalez Cristina Gomez‐Fernandez Gloria Ribas Conrado Martinez‐Cadenas 《Experimental dermatology》2017,26(10):896-903
Sunlight exposure induces signalling pathways leading to the activation of melanin synthesis and tanning response. MicroRNAs (miRNAs) can regulate the expression of genes involved in pigmentation pathways by binding to the complementary sequence in their 3′untranslated regions (3′UTRs). Therefore, 3′UTR SNPs are predicted to modify the ability of miRNAs to target genes, resulting in differential gene expression. In this study, we investigated the role in pigmentation and sun‐sensitivity traits, as well as in melanoma susceptibility, of 38 different 3′UTR SNPs from 38 pigmentation‐related genes. A total of 869 individuals of Spanish origin (526 melanoma cases and 343 controls) were analysed. The association of genotypic data with pigmentation traits was analysed via logistic regression. Web‐based tools for predicting the effect of genetic variants in microRNA‐binding sites in 3′UTR gene regions were also used. Seven 3′UTR SNPs showed a potential implication in melanoma risk phenotypes. This association is especially noticeable for two of them, rs2325813 in the MLPH gene and rs752107 in the WNT3A gene. These two SNPs were predicted to disrupt a miRNA‐binding site and to impact on miRNA‐mRNA interaction. To our knowledge, this is the first time that these two 3′UTR SNPs have been associated with sun‐sensitivity traits. We state the potential implication of these SNPs in human pigmentation and sensitivity to sunlight, possibly as a result of changes in the level of gene expression through the disruption of putative miRNA‐binding sites. 相似文献
992.
Casey Walsh Barbara Jones Alison Schonwald 《Journal of autism and developmental disorders》2017,47(4):980-991
Improving the health care transition process for youth with autism spectrum disorder (ASD) is critically important. This study was designed to examine the overall national transition core outcome among youth with ASD and each of the component measures of health care transition planning. Fewer than 10% of youth with ASD meet the national transition core outcome. Among youth with ASD, there is greater disparity in health care transition planning for non-Hispanic black youth, youth with family income <400% of the federal poverty line, and youth with more severe activity limitation. Continued advocacy, research, and training efforts are needed to reduce disparities in receipt of health care transition planning services for youth with ASD. 相似文献
993.
994.
Mouna Barat-Houari Karine Nguyen Rafa?lle Bernard C��line Fernandez Catherine Vovan Corinne Bareil Philippe Khau Van Kien Delphine Thorel Sylvie Tuffery-Giraud Francis Vasseur Shahram Attarian Jean Pouget Anne Girardet Nicolas L��vy Mireille Claustres 《European journal of human genetics : EJHG》2010,18(5):533-538
995.
996.
Marta Fernandez Sampedro Kerryl E. Piper Andrew McDowell Sheila Patrick Jayawant N. Mandrekar Mark S. Rouse James M. Steckelberg Robin Patel 《Diagnostic microbiology and infectious disease》2009
Propionibacterium sp. is commonly isolated in association with orthopedic implants, either as a pathogen or a colonizer. Microbial characteristics that indicate whether the isolated species is a likely cause of orthopedic implant infection versus a colonizing agent would be clinically useful. We performed a prospective trial to determine the species of Propionibacterium and the phylotype (IA, IB, II, III) of Propionibacterium acnes isolated from the surface of removed orthopedic implants, and we correlated these findings with the presence or absence of infection. P. acnes represented 61 of 62 isolates. P. acnes type I was more commonly isolated than was type II (62% versus 38%, respectively), whether associated with infection or not. P. acnes type III was not detected. There was no clear association between types I and II P. acnes and infection or colonization of failed orthopedic implants (P = 0.75), however type IB strains were more frequently isolated than type IA from infected prosthese. 相似文献
997.
998.
999.
1000.
Alison O. Jordan Louise R. Cohen Graham Harriman Paul A. Teixeira Jacqueline Cruzado-Quinones Homer Venters 《AIDS and behavior》2013,17(2):212-219
New York City (NYC) jails are the epicenter of an epidemic that overwhelmingly affects Black and Hispanic men and offer a significant opportunity for public health intervention. The NYC Department of Health and Mental Hygiene instituted population based approaches to identify the HIV-infected, initiate discharge planning at jail admission, and facilitate post-release linkages to primary care. Using a caring and supportive ‘warm transitions’ approach, transitional care services are integral to continuity of care. Since 2010, over three-quarters of known HIV-infected inmates admitted to jails received discharge plans; 74 % of those released were linked to primary care. The EnhanceLink initiative’s new Health Liaison, a lynchpin role, facilitated 250 court-led placements in medical alternatives to incarceration. Transitional care coordination programs are critical to facilitate continuity of care for people with chronic health conditions including the HIV-infected returning home from jail and for the public health of the communities to which they return. 相似文献