全文获取类型
收费全文 | 60684篇 |
免费 | 2924篇 |
国内免费 | 327篇 |
专业分类
耳鼻咽喉 | 514篇 |
儿科学 | 1224篇 |
妇产科学 | 857篇 |
基础医学 | 7921篇 |
口腔科学 | 1364篇 |
临床医学 | 3894篇 |
内科学 | 15318篇 |
皮肤病学 | 1146篇 |
神经病学 | 4451篇 |
特种医学 | 2258篇 |
外科学 | 10986篇 |
综合类 | 284篇 |
预防医学 | 1779篇 |
眼科学 | 1000篇 |
药学 | 4163篇 |
中国医学 | 164篇 |
肿瘤学 | 6612篇 |
出版年
2023年 | 316篇 |
2022年 | 624篇 |
2021年 | 1107篇 |
2020年 | 641篇 |
2019年 | 848篇 |
2018年 | 1135篇 |
2017年 | 871篇 |
2016年 | 1038篇 |
2015年 | 1141篇 |
2014年 | 1550篇 |
2013年 | 1788篇 |
2012年 | 2910篇 |
2011年 | 3178篇 |
2010年 | 1791篇 |
2009年 | 1529篇 |
2008年 | 2826篇 |
2007年 | 3082篇 |
2006年 | 3043篇 |
2005年 | 3211篇 |
2004年 | 3289篇 |
2003年 | 3218篇 |
2002年 | 3108篇 |
2001年 | 1937篇 |
2000年 | 1832篇 |
1999年 | 1841篇 |
1998年 | 914篇 |
1997年 | 732篇 |
1996年 | 670篇 |
1995年 | 584篇 |
1994年 | 555篇 |
1993年 | 496篇 |
1992年 | 1144篇 |
1991年 | 1065篇 |
1990年 | 934篇 |
1989年 | 1001篇 |
1988年 | 882篇 |
1987年 | 793篇 |
1986年 | 835篇 |
1985年 | 764篇 |
1984年 | 530篇 |
1983年 | 444篇 |
1982年 | 255篇 |
1981年 | 255篇 |
1980年 | 202篇 |
1979年 | 361篇 |
1978年 | 288篇 |
1977年 | 255篇 |
1975年 | 240篇 |
1974年 | 210篇 |
1973年 | 196篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
H Sanui T M Redmond S Kotake B Wiggert T Tanaka G J Chader I Gery 《Current eye research》1990,9(2):193-199
Monkeys immunized with bovine IRBP-derived synthetic peptides R4 (sequence 1158-1180) or R14 (1169-1191) developed EAU which was detected by both clinical and histological examinations. The inflammation localized mainly in the choroid, with only minor changes being noticed in the adjacent retinal tissue. EAU developed in only one of the two monkeys immunized with each of the peptides and the animals with disease also showed higher levels of cellular immunity toward the immunizing peptide than did the monkeys with no disease. The cellular immune responses, measured by the lymphocyte proliferation assay, were specific toward the immunizing peptides, with no cross responsiveness to whole IRBP. This finding suggests that the two uveitogenic peptides were non-immunodominant in the tested monkeys. In contrast, peptide R14 is highly immunodominant in the Lewis rat. Also, the fine specificity of the monkey response to R14 differed from that of the Lewis rat. The possible genetic control of the monkey susceptibility to EAU induction by the peptides is discussed and the unique finding of an autoimmune disease induction by a non-immunodominant peptide is underscored. 相似文献
92.
Masazumi Zaima Keisuke Nagamatsu Akira Mitsuyoshi Shinji Murata Toshihumi Takeuchi Akira Kobayashi 《Urology》1997,49(6):948-950
A new surgical technique to treat retroperitoneal tumors with supradiaphragmatic vena caval invasion is described. In this technique, hepatic warm ischemia can be avoided with reversed hepatic outflow through the portal vein and neither hypothermic circulatory arrest nor cardiopulmonary bypass is necessary using centrifugal blood pump-driven bypass. 相似文献
93.
Akira Seto Shigehiro Morikawa Takahiro Isono Katsuhiko Ogawa Toshiro Inubushi 《Journal of medical virology》1995,46(3):224-229
Inbred rabbits of B/Jas strain were found to be highly susceptible to herpes simplex virus type 1 encephalitis, following i.v. injection of the virus, while Chbb:HM strain rabbits were not susceptible. The susceptibility trait seemed to be inherited recessively, involving multiple genes, because (B/Jas x Chbb:HM)Fl hybrids were as resistant as Chbb:HM rabbits, and because more than 90% of backcrosses of (B/Jas x Chbb: HM)FI to B/Jas were resistant to viral inoculation. The encephalitis in B/Jas rabbits resembled human herpes simplex encephalitis, in that the temporal lobe as well as the brain stem were affected preferentially, leading to the development of various types of seizures, such as circling, loss of balance leading to a fall, and tonic and clonic convulsions. The disease could be diagnosed by magnetic resonance imaging (MRI) analysis before onset of seizures, and diseased rabbits showed a marked lymphopenia at onset of seizures. © 1995 Wiley-Liss, Inc. 相似文献
94.
Although propylene oxide, which is similar in chemical structure to ethylene oxide, is expected to produce neuropathy, there is no convincing evidence of the degeneration of the peripheral nervous system. To determine the exposure concentration of propylene oxide necessary to produce neuropathy in male Wistar rats, we subjected them to repeated exposures of propylene oxide at concentrations of 500, 750, 1000, 1500 and 2000 ppm. The test rats were subjected to a single 6 hour exposure of propylene oxide at a concentration of 1500 parts per million 5 times a week for 3 weeks. They developed a significant decrease in body weight, abnormal posture of the hindlegs and axonal degeneration of myelinated fibers in the peroneal and sural nerves, the nerves to the soleus muscle, and in the fasciculus gracilis of the spinal cord. Therefore, it was concluded that propylene oxide induces neuropathy in rats characterized by axonal degeneration, similar to that produced by ethylene oxide, and that the exposure to the higher concentration of propylene oxide is more necessary to produce neuropathy than in the case of ethylene oxide neuropathy in rats. 相似文献
95.
96.
Yasuhisa Fujibayashi Hideyuki Taniuchi Kouichi Wada Yoshiharu Yonekura Junji Konishi Akira Yokoyama 《Annals of nuclear medicine》1995,9(1):1-5
The reductive retention of62Cu-PTSM was comparatively studied in the brain and Ehrlich ascites tumor cells by electron spin resonance spectrometry and nonradioactive Cu-PTSM. In the brain, only the mitochondrial fraction showed the ability to reduce Cu-PTSM, and the other subcellular fractions did not. In contrast, the cytosolic fraction of Ehrlich ascites tumor cells was the specific site of Cu-PTSM reduction. It was therefore considered that the retention of Cu-PTSM in the brain is closely related to mitochondrial reduction, most probably involving the mitochondrial electron transport system. 相似文献
97.
98.
M Tanaka 《Japanese journal of cancer research》1992,83(2):194-199
We have evaluated the feasibility of enhancing the cytotoxic effect of cytosine arabinoside (ara-C) on acute myeloid leukemia (AML) cells by increasing the proliferative activity with hematopoietic growth factors. Leukemic cells from 8 persons with AML were tested. Preincubation with interleukin (IL)-3 (5 U/ml) for 3 days increased DNA synthesis as measured by tritiated thymidine incorporation and Ki67 expression in cells from 7 out of 8 persons with AML. Leukemic cells preincubated with IL-1 (10 U/ml) or IL-3 (5 U/ml) were subsequently exposed to ara-C (3 micrograms/ml) for the final 24 h and the activity of ara-C against clonogenic acute myeloid leukemia cells was evaluated in terms of the inhibition of colony formation in semisolid media. The exposure to ara-C inhibits the proliferation of a higher proportion of clonogenic cells in culture pretreated with IL-3 than in control or cells pretreated with IL-1. The enhanced cytotoxic effect of ara-C in the cells pretreated with IL-3 correlated with increased formation of intracellular ara-CTP. IL-3-induced recruitment of quiescent blasts into the proliferative compartment will lead to increased formation of ara-CTP in the cells, which would result in an enhanced leukemia cell kill. 相似文献
99.
100.
Shigeki Ohgitani Akimitsu Miyauchi Yasuyuki Takagi Yoshio Fujii Takuo Fujita Misa Nakamura Zhi-qiang Zhang Liang Shan Mitsuyo Sasaki Ryuichi Tsukino Toyoharu Yokoi Kennichi Kakudo Tomitaka Nakayama Junya Toguchida Hiroshi Kanoe Shinichi Aizawa Masao S. Sasaki Takashi Nakamura M. Suda K. Tanaka Y. Ogawa N. Tamura A. Yasoda H. Itoh M. Uehira N. Nishimoto T. Takigawa K. Shiota K. Nakao 《Journal of bone and mineral metabolism》1997,15(3):165-171