全文获取类型
收费全文 | 3379篇 |
免费 | 134篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 54篇 |
儿科学 | 66篇 |
妇产科学 | 15篇 |
基础医学 | 456篇 |
口腔科学 | 48篇 |
临床医学 | 234篇 |
内科学 | 951篇 |
皮肤病学 | 25篇 |
神经病学 | 225篇 |
特种医学 | 72篇 |
外科学 | 620篇 |
综合类 | 9篇 |
预防医学 | 85篇 |
眼科学 | 57篇 |
药学 | 257篇 |
中国医学 | 5篇 |
肿瘤学 | 360篇 |
出版年
2023年 | 32篇 |
2022年 | 47篇 |
2021年 | 64篇 |
2020年 | 27篇 |
2019年 | 61篇 |
2018年 | 78篇 |
2017年 | 44篇 |
2016年 | 65篇 |
2015年 | 57篇 |
2014年 | 82篇 |
2013年 | 108篇 |
2012年 | 193篇 |
2011年 | 218篇 |
2010年 | 117篇 |
2009年 | 118篇 |
2008年 | 195篇 |
2007年 | 209篇 |
2006年 | 243篇 |
2005年 | 203篇 |
2004年 | 210篇 |
2003年 | 197篇 |
2002年 | 167篇 |
2001年 | 68篇 |
2000年 | 67篇 |
1999年 | 67篇 |
1998年 | 53篇 |
1997年 | 34篇 |
1996年 | 36篇 |
1995年 | 33篇 |
1994年 | 27篇 |
1993年 | 25篇 |
1992年 | 53篇 |
1991年 | 36篇 |
1990年 | 30篇 |
1989年 | 32篇 |
1988年 | 44篇 |
1987年 | 18篇 |
1986年 | 26篇 |
1985年 | 20篇 |
1984年 | 16篇 |
1983年 | 17篇 |
1982年 | 6篇 |
1981年 | 9篇 |
1980年 | 6篇 |
1979年 | 10篇 |
1978年 | 23篇 |
1977年 | 9篇 |
1976年 | 5篇 |
1975年 | 8篇 |
1974年 | 8篇 |
排序方式: 共有3539条查询结果,搜索用时 15 毫秒
91.
Apoptosis and p53 expression in chondrocytes relate to degeneration in articular cartilage of immobilized knee joints 总被引:9,自引:0,他引:9
Okazaki R Sakai A Ootsuyama A Sakata T Nakamura T Norimura T 《The Journal of rheumatology》2003,30(3):559-566
OBJECTIVE: We have reported that articular cartilage showed early stage degeneration at 7 and 14 days after immobilization, moderate degeneration at 28 days, and severe degeneration at 42 days in rabbits. To test whether apoptosis occurs in association with p53 expression in chondrocytes during the process of articular cartilage degeneration, we investigated the degree of cartilage degeneration, the frequency of apoptotic cells, and the levels of p53 mRNA in rabbits and mice after knee immobilization. METHODS: Right knees of male Japanese white rabbits were immobilized in full extension with fiberglass casts for up to 42 days. Similarly, right knees of male p53 wild-type [p53 (+/+)] and p53 null [p53 (-/-)] mice were immobilized in full extension with bandage tape for up to 84 days. Apoptotic cells were confirmed by TUNEL staining on the sections of knee joints. Total RNA of articular chondrocytes obtained from Day 0 or immobilized knees was analyzed semiquantitatively by RT-PCR using specific primers for p53. RESULTS: Articular cartilage degenerated after immobilization of p53 (+/+) mouse knees, but not after immobilization of p53 (-/-) knees. Apoptotic cells were observed in articular cartilage in the femur and tibia of rabbits and p53 (+/+) mice after immobilization. However, only a few apoptotic cells were observed at the same sites in p53 (-/-) mice. In RT-PCR analysis, the levels of p53 mRNA obtained from immobilized groups were significantly higher than those of Day 0 groups in rabbit and p53 (+/+) mouse knees. CONCLUSION: Apoptosis and p53 expression in chondrocytes relate to degeneration in articular cartilage of immobilized knee joints. 相似文献
92.
Matsuo K Nagano Y Sugimori K Taniguchi K Gorai K Kunisaki C Ike H Tanaka K Imada T Kamijo S Nozawa A Nakatani Y Miura Y Tanaka K Endo I Sekido H Togo S Shimada H 《Journal of gastroenterology》2005,40(3):306-311
Primary malignant peripheral nerve-sheath tumors of the common bile duct are extremely rare. To our knowledge, the published literature contains no previous case report of this disease. Here we report on a 58-year-old Japanese woman with a primary malignant peripheral nerve-sheath tumor of the common bile duct, which was completely resected. A hypoechoic mass was identified in the hepatic hilus, using ultrasonography and computed tomography. Endoscopic retrograde cholangiography revealed a smooth stricture and deviation of the common bile duct. Laparotomy exposed a firm mass around the common bile duct that had not invaded the surrounding tissues. Partial resection of the common bile duct and cholecystectomy were performed as the treatment of choice. The final histopathological diagnosis was malignant peripheral nerve-sheath tumor arising from the wall of the common bile duct. 相似文献
93.
94.
Hepatitis B virus markers and antibodies to hepatitis C virus in Japanese patients with hepatocellular carcinoma 总被引:4,自引:0,他引:4
Nobukazu Yuki MD Dr. Norio Hayashi MD Akinori Kasahara MD Hideki Hagiwara MD Kazuhiro Katayama MD Hideyuki Fusamoto MD Takenobu Kamada MD 《Digestive diseases and sciences》1992,37(1):65-72
Sera from Japanese patients with chronic liver disease were tested for hepatitis B virus (HBV) markers and antibodies to hepatitis C virus (anti-HCV), and the results were correlated to the presence of hepatocellular carcinoma. In chronic non-A, non-B liver disease, anti-HCV prevalence was high both in patients with hepatocellular carcinoma (78/89, 88%) and without it (66/84, 79%), while previous HBV infection was more common in patients with hepatocellular carcinoma (65/89, 73%) than in those without it (46/84, 55%) (P<0.05). Coexistence of anti-HCV and antibodies to HBV was observed frequently in patients with hepatocellular carcinoma (56/89, 63%) compared with patients without it (39/84, 46%) (P<0.05). In chronic HBV carriers, anti-HCV was more common in patients with hepatocellular carcinoma (12/38, 32%) than in those without it (3/62, 5%) (P<0.01). These results suggest that infection with the two viruses may be a risk factor for more serious liver disease.This work was supported by a Grant-in-Aid from the Ministry of Education, Science and Culture, Japan. 相似文献
95.
Jun Hayashi M.D. Wataru Kajiyama Akinori Noguchi Koya Nakashima Miki Hirata Shin Hayashi Seizaburo Kashiwagi 《Journal of gastroenterology》1991,26(6):742-746
Seventeen patients with chronic hepatitis B were treated with a 4-week administration of glycyrrhizin followed by a 4-week
treatment with human lymphoblastoid interferon, then followed for 6 months after the end of treatment. All were positive for
hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and hepatitis B virus-associated DNA polymerase (DNA-p)
for at least 6 months before entry. All patients were Japanese and none of them were homosexuals. Eleven patients lost DNA-p
activity and 10 of them lost HBeAg. Three of these 10 patients had antibody to HBeAg. In 10 patients who became HBeAg-negative,
alanine aminotransferase levels after glycyrrhizin administration were higher and initial DNA-p activities relatively lower
than the levels found in seven patients who remained HBeAg-positive. The immunomodulater provided by a short course of glycyrrhizin
before administration of human lymphoblastoid interferon may be an effective treatment for patients with chronic hepatitis
B. 相似文献
96.
Healthy HTLV-I carriers in Japan: the haematological and immunological characteristics 总被引:5,自引:0,他引:5
Kaori Yasuda Yoshitatsu Sei Mitchel M. Yokoyama Ken Tanaka Akinori Har† 《British journal of haematology》1986,64(1):195-203
The haematological and immunological characteristics of 34 healthy anti-HTLV-I antibody-positive individuals (HTLV-I carriers) in southwestern Japan were examined. No significant difference was noted between carriers and the controls in counts of RBC, WBC and the absolute number of lymphocytes. The serum IgG in the carriers was higher than that of the controls. The percentages of OKT4, OKT8, OKIa1 and B1-positive cells were found to be normal in the peripheral blood of the carriers, whereas the percentages of OKT11 and anti-Tac-positive cells were significantly higher in the carriers than in the controls. A correlation was observed between the percentages of anti-Tac-positive cells and the titres of anti-HTLV-I antibody in the carriers. After a 72 h incubation of peripheral blood lymphocytes with medium alone, the percentage of anti-Tac-positive cells tended to decrease in the controls, but to increase in carriers, with the appearance of large blastoid cells resembling blastic transformed lymphocytes cultured with mitogen. Tac and Ia antigens were markedly expressed on these large blastoid cells. 相似文献
97.
Akihiro Takahashi Masaya Umezaki Yasuyuki Yoshida Akinori Kuzuya 《Journal of biomaterials science. Polymer edition》2014,25(5):444-454
We report on the effects of number and length of PEG chains in poly(depsipeptide-co-dl-lactide)-g-poly(ethylene glycol) (P(DG-dl-LA)-g-PEG) copolymers on their sol-to-gel transition behavior. The graft-type copolymer is suitable for the systematic study of the effects of molecular structure and hydrophilic/hydrophobic balance on its sol-to-gel transition. We prepared various P(DG-dl-LA)-g-PEG copolymers through coupling reactions between the pendant carboxylic acid groups of P(GD-dl-LA) and the end hydroxyl group of MeO-PEG having various molecular weights. Temperature-responsive sol-to-gel transition of the obtained copolymer solution in phosphate-buffered solution (pH 7.4, ionic strength = 0.14) was investigated by the test tube inverting method and rheological measurements. P(GD-dl-LA)-g-PEG copolymer prepared from higher molecular weight PEG showed higher sol-to-gel transition temperatures compared with the copolymers prepared from lower molecular weight PEG, although these copolymers have similar weight content of PEG (23–24?wt.%). Similar trends were observed for groups of copolymers whose PEG contents were 27 or 30?wt.%. These results are informative for providing strategies on rational design of thermo-gelling polymers. 相似文献
98.
99.
Case series of 17 patients with cholangiocarcinoma among young adult workers of a printing company in Japan
下载免费PDF全文
![点击此处可从《Journal of hepato-biliary-pancreatic sciences》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Shoji Kubo Yasuni Nakanuma Shigekazu Takemura Chikaharu Sakata Yorihisa Urata Akinori Nozawa Takayoshi Nishioka Masahiko Kinoshita Genya Hamano Hiroaki Terajima Gorou Tachiyama Yuji Matsumura Terumasa Yamada Hiromu Tanaka Shoji Nakamori Akira Arimoto Norifumi Kawada Masahiro Fujikawa Hiromitsu Fujishima Yasuhiko Sugawara Shogo Tanaka Hideyoshi Toyokawa Yuko Kuwae Masahiko Ohsawa Shinichiro Uehara Kyoko Kogawa Sato Tomoshige Hayashi Ginji Endo 《Journal of hepato-biliary-pancreatic sciences》2014,21(7):479-488
100.
Yagihara N Sato A Iijima K Izumi D Furushima H Watanabe H Irie T Kaneko Y Kurabayashi M Chinushi M Satou M Aizawa Y 《Journal of electrocardiology》2012,45(1):36-42
We determined the prevalence of J waves in the electrocardiograms (ECG) of 120 patients with Wolff-Parkinson-White syndrome in comparison with J-wave prevalence in a control group of 1936 men and women with comparable demographic and ECG characteristics and with normal atrioventricular conduction. J waves were present only during manifest preexcitation in 22 of 120 patients (18.3%), disappearing after catheter ablation and suggesting that J waves were associated with the presence of preexcitation. J waves were present in 19 (15.8%) of 120 patients only after ablation, apparently having been masked by early depolarization of the preexcited myocardial region, and in 22 patients (18.3%), J waves were not altered significantly by preexcitation. Thus, the overall J-wave prevalence was 52.5% (63/120) and, excluding those apparently due to preexcitation, 34.8% (41/120), both substantially higher than the prevalence (11.5%) in the control group (P < .001 for both). The patients with J waves appearing only during preexcitation were younger, predominantly females. The presence of J waves after ablation was associated with a history of atrial fibrillation and shorter ventricular effective refractory period. It is concluded that the prevalence of J waves is high in patients with Wolff-Parkinson-White syndrome and is influenced by manifest preexcitation. 相似文献