颅内垂体腺瘤合并脑膜瘤一例

患者女性，56岁。因反复头痛4年，视物模糊10个月，右眼视力下降5个月入院。查体：左眼视力正常，右眼视力40cm指数，视野双颞侧偏盲。X片示蝶鞍轻度扩大。CT：鞍区扩大，垂体窝有一肿块影，内呈囊性，右额叶大脑侧面有一圆形高密度影。MRI：蝶鞍扩大下凹，鞍区见一囊状实性信号肿块影，他相有液平面，FLAIR示高信号。增强可见囊壁及其分隔显著环状强化，     

100例脑外伤后综合征临床与脑电图关系探讨

本文初步探讨１００例脑外伤后综合征的临床与及图（ＥＥＧ）的关系。病员有束之高阁下状而无神经系统阳性体片，ＣＴ扫描检查均正常而ＥＥＧ检查异常者占３２％。在ＥＧ诊断正常的病例中，有６０％的病员显示α波的调幅，对称性较健康人差，呈弥漫性α波表现。异常ＥＥＧ及上述α波提示可能与大脑或丘脑下部功能轻度障碍有关，反之，则其临床症状与心理因素有关，在诊治中应予区别对待。     

pSVPoMCAT微基因修饰雪旺氏细胞移植治疗实验性脊髓损伤的酶及免疫组化评价

Genetherapyofspinalcordinjury（SCI）remainsintheexper－imentalstage．Now，neurotrophicfactortomodifySchwanncell（SC）orfibroblastsareimplantedintoSCIregiontoobservetheregenera－tionsofaxons犤１犦．WefirstbuildPo－５＇－flankinginducedmicrogeneforbasicproteinofmyelinsheathwhichistransientlynamedaspSVPoMcat．ThepSVPoMcatgenewasintroducedintoSCthroughcationliposome．ItwasprovedthatpSVPoMcatcouldenhancefunc－tionofSCandelongateitssurvivalperiodinvitro犤２犦．pSVPoMcatwasimplantedintoS…     

胶质瘤干细胞免疫作用机制与免疫治疗研究进展

胶质母细胞瘤是一种恶性程度较高的胶质瘤。迄今使用常规方法治疗胶质母细胞瘤很难得到让人满意的效果。许多研究显示,胶质瘤干细胞和其所处的免疫微环境的抑制状态是胶质母细胞瘤难以治疗的根源。本文通过探讨胶质瘤干细胞所处免疫微环境中相关免疫细胞的作用,重点分析胶质瘤干细胞的免疫逃逸的机制,并描述现今主要的免疫治疗的临床策略,希望有助于为临床治疗找到新途径。     

脑胶质瘤患者精神障碍的研究进展

<正>胶质瘤患者手术前后均可能存在不同程度的精神障碍~([1]),但神经外科医师常常更关注如何延长患者生存时间,对胶质瘤相关精神障碍的评估及治疗有所忽略,导致患者生活质量降低,也给患者家庭照顾者带来了极大困扰~([2,3])。全面了解胶质瘤患者精神心理状况可以更好地评价预后、提高患者生存质量。本文就近年来胶质瘤患者精神障碍相关研究进展展开综述。     

带膜支架治疗外伤性颈动脉海绵窦瘘(附12例报告)

目的 探讨带膜支架治疗外伤性颈动脉海绵窦瘘(TCCF)的方法、结果 和特点.方法 自2006年1月至2009年1月应用带膜支架治疗外伤性颈动脉海绵窦瘘患者12例,其中1例为双侧颈动脉海绵窦瘘,12例患者共置入13枚带膜支架.结果 所有患者均用带膜支架成功治疗.术后立即造影显示所有瘘口消失,颈内动脉保持通畅.随访6个月至2年(平均14.2个月),均未见复发,颈内动脉保持通畅,没有狭窄或闭塞.结论 带膜支架治疗TCCF方法简便,安全可靠,效果良好,是TCCF可供选择的一种治疗方法,但有其适应证和局限性.     

68例急性重度颅脑损伤的救治体会

目的：探讨基层医院重度颅脑损伤患者抢救成功率的诊治措施。方法：回顾性分析68例重度颅脑损伤患者的急诊抢救、住院手术及康复治疗的临床资料。结果：68例重度颅脑损伤患者有63例在急诊抢救室初步抢救成功,为进一步治疗提供了机会。住院病例主要采取手术治疗,共56例,其中去骨瓣减压术34例,均早期康复治疗。采用GOS结果分析及半年随访,1级7例（人院后2h死亡2例,术后死亡5例）,2级6例,3级15例,4级16例,5级19例。结论：急诊室抢救、积极手术及早期康复治疗是提高重度颅脑损伤患者的抢救成功率的三个主要环节。     

显微外科治疗儿童髓母细胞瘤

目的 用显微技术切除儿童髓母细胞瘤，砬少手术并发症，提高术后生存质量。方法 对３４例儿童髓平细胞瘤的临床资料进行分析。结果 ３４例均采用显微手术治疗，全切２７例，次全切除４例，部分切除３例，手术死亡２例，死亡率为５．９％，获随该列，临床治愈２４例，着状改善６例，５年生存率为５０％。结论 微创的显微外科技术是保证减少术后并发症，获得良好预后的关键。对于大多数患儿，建议术后辅以放疗。     

Repair effect of Schwann cells modified by microgene pSVPoMcat on injured spinal cord in rats

OBJECTIVE: To observe the repair effect of Schwann cells (SCs) modified by microgene pSVPoMcat on injured spinal cord in rats. METHODS: Semi-transection injury at the level of T(8) of spinal cord was made with cutting method on 120 Sprague Dawley (SD) rats. Then 40 rats implanted with SCs modified by microgene pSVPoMcat were taken as Group A, 40 rats implanted with simple SCs as Group B and the other 40 rats were taken as the control group (Group C). The functional recovery of the rats was observed through combined behavioral score (CBS) and cortical somatosensory evoked potential (CSEP), and the expression of the glial fibrillary acidic protein (GFAP) was measured with in situ hybridization and immunocytochemistry. At 3 months after operation, the rats were examined with magnetic resonance image (MRI), and the neurofilaments (NF) of the axons were stained with immunohistochemical method. RESULTS: GFAP expression in Group A was significantly lower than that of the other 2 groups. MRI showed that the spinal signals in the injured area recovered fundamentally in Group A, didn't recover in Group B and malacia focus was found in Group C, which was same as the results of NF staining. Wave amplitudes in incubation periods in Group A and Group B tended to recover. It recovered to the normal level in Group A, which was similar to the results of CBS. CONCLUSIONS: SCs modified by microgene pSVPoMcat can inhibit GFAP expression, improve the growth of the axons and the functional recovery of neurons after spinal cord injury.