一氧化碳中毒的局限性及对策

<正> 目前国内用高压氧治疗一氧化碳中毒的急性期病人治愈率为95.3%～96.8%,后续症的冶愈率可达71％。我院自1991年引进宁波医技设备厂生产的DYC750A型单人高压氧仓治疗急性一氧化碳中毒及其后续症,由于单仓治疗的局限性,如医护人员不能进入仓内,在氧疗同时抢救休克及呼吸衰竭,痰多时不能及时疏通气道等,急性期的治愈率为90.8%,后续症的治愈率仅达半数。为此,我们采取了相应的对策,提高了治愈率。 临床资料及方法 本文资料均为1991年以来我院收治的经病史HbCO测定确诊的一氧化碳中毒病人。按时间分为前后两组。     

硫酸镁超早期治疗急性脑梗死疗效观察

脑梗死发病率高，致残率高，严重危害人类健康。我们应用硫酸镁超早期治疗急性脑梗死40例，效果满意，现报告如下。     

乳腺癌患者生命质量测定量表中文版的制定与考评

目的研制乳腺癌生存质量测定量表EORTC QLQ-BR23的中文版,并对其进行考评.方法 通过量表的翻译、回译及文化调适制定中国版的EORTC QLQ-BR23,并通过122例乳腺癌患者进行的生存质量测定对量表进行评价.所用到的统计学方法有相关分析及配对t检验.结果 8个领域的重测信度均在0.75以上;各领域内部一致性信度的α值均在0.7以上;各条目与其领域的相关系数r值均在0.6以上.结论 EORTC QLQ-BR23中文版具有较好的信度和效度,可用于中国乳腺癌患者的生存质量测定,其反应度有待于进一步的研究.     

氯氮平与氯丙嗪治疗精神分裂症对照观察

氯氮平是新型抗精神病药,为总结临床经验,我们将氯氮平与氯丙嗪进行了临床对照研究,现将结果报告如下: 资料与方法病例选择入组条件:①符合中华医学会1984年精神分裂症诊断标准,②年令:18～55岁,③无严重心肝肾等躯体疾病,④无癫痫和药物过敏史。     

去细胞喉支架的制备及喉肌细胞再生的可行性研究

Objective To prepare a deeelhilarized whole laryngeal scaffold by utilizing a perfusion-decellularized technique, reseed cells on it, and construct recellularized laryngeal muscles. Methods Perfusion decelluarized larynxes were obtained by common carotid arterious perfusion with detergents. Then they were performed by macroscopic view, histological examination, scanning electron microscopy (SEM) and cartilage viability. Decellularized laryngeal scaffold were then reseeded with inducted mesenchymal stem cells (MSCs). Composites were transferred into greater omentums of rabbits after one day' s adherence and harvested after eight weeks. Macroscopic view, histological examination and immunohistochemistry were performed. Results Perfusion larynxes became transparent after two hours. Histology and SEM indicated that perfnsion method shewed better deculluarized effect. More ventages and collagen fibers but no intact cell or anclei were retained in the decellularized martrix. Porosity measured by Image pro plus 6. 0 was 80. 4% ± 3.2% (x ± s). Chondrocyte vitality assay indicated chondrocyte vitality rate in the perfusion group was 86. 9% ± 1.5% . After eight weeks, vascularization formed and integrated cartilage frameworks still remained. Histological examination could clearly show the presence of muscle bundles and vessels. Immunohistoehemical examination indicated that sarcomeric-α actin expressed positively in corresponding areas. Conclusions It is feasible to reseed MSCs into the decellularized laryngeal muscle matrix for constructing tissue-engineered laryngeal muscles. This in vivo maturation into the omentum could be the first step before in situ implantation of the construct.     

酒精型气雾杀虫剂的研制及对蚊蝇蟑螂药效观察

目的 :研制一种药效高、气味好、耐腐蚀的气雾杀虫剂 ;方法 :分别测试实验室、模拟现场、现场、贮存稳定性、耐压、耐腐蚀性、毒性试验结果 ;结果 :实验室按 1.0 g/筒喷雾 ,对蚊蝇的 K T50 均小于 1.0分钟 ,对德国小蠊 K T50 为 6.3分钟 ,三种害虫的 2 4h死亡率均达 10 0 ;模拟现场 ,对蚊蝇和德国小蠊分别按 0 .3 g/m3 和5 .0 g/m2的剂量喷雾后 ,三种害虫 1h击倒率和 2 4h击倒率均为 10 0 ;现场试验按 0 .3 g/m3剂量喷药后 ,蚊蝇 10分钟内全部击倒 ,2 4h死亡率均达 10 0 ;药液贮存两年后药效分解率小于 5 ,耐压、耐腐蚀性显示正常 ;毒性鉴定属实际无毒级 ,对眼结膜轻度充血 ,对皮肤无刺激性。结论 :该气雾杀虫剂用食用酒精作溶剂 ,在两年内使用可替代煤油制剂     

降粘化瘀法治疗慢型克山病血液流变学指标的探讨

克山病是以缺血缺氧性心肌坏死为主要特征的地方性心肌病。多年来人们已经注意到在冠心病、心肌梗塞等缺血性心脑血管病发病过程中的血液流变学方面的改变,并且在应用降粘、解聚、溶栓等中药的治疗中取得明显的治疗效果。作者曾对37例克山病患者进行了血液流变学的检测,结果表明:克山病患者的血液呈现高粘滞状态。为了改善这一状态,作者对