The changes of plasma 8-iso-prostaglandin F2αand serum C-reactive protein levels in patients with obstructive sleep apnea-hypopnea syndrome

Objective To investigate the plasma 8-iso-prostaglandin F2α(8-iso-PGF2α and the serum C-re-active protein(CRP) levels in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS) with and without hypertension(OSAHS + HT),and to explore the changes of pathophysiology in patients with OSAHS and the patho-genesis of OSAHS + HT. Methods All observed subjects were divided into 3 groups: control group (n=20),OS-AHS group(n=19),OSAHS + HT group (n=21). Plasma 8-iso-PGF2αand serum CRP concentrations levels were measured by ELISA and were compared. Results The plasma 8-iso-PGF2αand serum CRP levels,were higher in OSAHS patients than those in control subjects [(11.08±3.26)μg/L vs (7.49±2.10)μg/L,P<0.01;(1.75±0.82) mg/L vs (0.52±0.26 ) mg/L,P<0.01],and were higher in OSAHS + HT group than those in control group [14.84±3.43)μG/L vs(11.08±3.26)μg/L,P<0.01 ;(3.13±1.06)mg/L vs(1.75±0.82)mg/L,P<0.01]. Conclusions Oxidative stress and inflammation in OSAHS patients are increased,which are involved in the devel-opment of OSAHS associated hypertension.     

The changes of plasma 8-iso-prostaglandin F2αand serum C-reactive protein levels in patients with obstructive sleep apnea-hypopnea syndrome

Objective To investigate the plasma 8-iso-prostaglandin F2α(8-iso-PGF2α and the serum C-re-active protein(CRP) levels in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS) with and without hypertension(OSAHS + HT),and to explore the changes of pathophysiology in patients with OSAHS and the patho-genesis of OSAHS + HT. Methods All observed subjects were divided into 3 groups: control group (n=20),OS-AHS group(n=19),OSAHS + HT group (n=21). Plasma 8-iso-PGF2αand serum CRP concentrations levels were measured by ELISA and were compared. Results The plasma 8-iso-PGF2αand serum CRP levels,were higher in OSAHS patients than those in control subjects [(11.08±3.26)μg/L vs (7.49±2.10)μg/L,P<0.01;(1.75±0.82) mg/L vs (0.52±0.26 ) mg/L,P<0.01],and were higher in OSAHS + HT group than those in control group [14.84±3.43)μG/L vs(11.08±3.26)μg/L,P<0.01 ;(3.13±1.06)mg/L vs(1.75±0.82)mg/L,P<0.01]. Conclusions Oxidative stress and inflammation in OSAHS patients are increased,which are involved in the devel-opment of OSAHS associated hypertension.     

大剂量静脉应用胺碘酮的护理

<正>现将淮安市第二人民医近年收治的静脉应用胺碘酮治疗心律失常29例的护理体会报告如下。1临床资料2005年2月～2008年2月,用胺碘酮治疗的心律失常29例,男20例,女9例。年龄26～74岁,平均53.7岁。病程15 d～2年,平均35.1 d。其中室性早博15例,持续性房颤2例,室性心动过速7例,室颤5例。住院14～45d,平均29.2 d。排除患者存在以下疾病:病窦综合征、房室传导阻滞、束支阻滞、长QT综合征、甲状腺功能障碍,肝硬化或其他肝脏疾病,碘过敏。     

刘启庭治疗胃脘痛经验

刘启庭主任医师治疗胃脘痛，辨证求因，审因论治，临证之时既喜用专方专药（川芎、党参、蒲公英），又强调辨证施药，随证加减；还重视调整患者的心理状态、饮食起居     

The changes of plasma 8-iso-prostaglandin F2αand serum C-reactive protein levels in patients with obstructive sleep apnea-hypopnea syndrome

Objective To investigate the plasma 8-iso-prostaglandin F2α(8-iso-PGF2α and the serum C-re-active protein(CRP) levels in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS) with and without hypertension(OSAHS + HT),and to explore the changes of pathophysiology in patients with OSAHS and the patho-genesis of OSAHS + HT. Methods All observed subjects were divided into 3 groups: control group (n=20),OS-AHS group(n=19),OSAHS + HT group (n=21). Plasma 8-iso-PGF2αand serum CRP concentrations levels were measured by ELISA and were compared. Results The plasma 8-iso-PGF2αand serum CRP levels,were higher in OSAHS patients than those in control subjects [(11.08±3.26)μg/L vs (7.49±2.10)μg/L,P<0.01;(1.75±0.82) mg/L vs (0.52±0.26 ) mg/L,P<0.01],and were higher in OSAHS + HT group than those in control group [14.84±3.43)μG/L vs(11.08±3.26)μg/L,P<0.01 ;(3.13±1.06)mg/L vs(1.75±0.82)mg/L,P<0.01]. Conclusions Oxidative stress and inflammation in OSAHS patients are increased,which are involved in the devel-opment of OSAHS associated hypertension.     

绝经后2型糖尿病患者血清25(OH)D、Leptin与骨代谢的相关性

目的探讨绝经后2型糖尿病(type 2 diabetes mellitus,T2DM)女性患者血清25-羟维生素D(25-hydroxyvitamin D,25(OH)D)、瘦素(leptin,LEP)水平与骨代谢之间的关系。方法选取遵义医学院附属医院内分泌科住院的绝经后T2DM女性患者130例,根据骨密度分为骨量正常组(A组,n=40)、骨量减少组(B组,n=45)和骨质疏松组(C组,n=45),同期选取50名健康绝经后女性作为空白对照组(NC组,n=50)。收集所有受试者临床资料及生化指标,测定血清25(OH)D、LEP、β-胶原降解产物(β-Crosslaps,β-CTX)、I型胶原N-端前肽(N-aminoterminal propeptide of type I collagen,PINP)及骨钙素(bone gla protein,BGP)水平。Spearmen相关分析绝经后T2DM合并骨质疏松症(osteoporosis,OP)患者血清骨代谢指标的相关因素分析;Logistic回归分析绝经后T2DM患者合并OP的影响因素。结果①与NC组比较,A、B、C三组中25(OH)D、PINP、BGP水平均明显降低,而LEP、β-CTX水平明显升高(P0.05);②与A组比较,B组、C组中25(OH)D、PINP水平均明显降低,而LEP、β-CTX、BGP水平明显升高(P0.05);③与B组比较,C组中25(OH)D、PINP水平均明显降低,而LEP、β-CTX、BGP水平明显升高(P0.05);Spearmen相关分析显示,血清25(OH)D与PINP呈正相关,与β-CTX呈负相关,与BGP无明显相关性;血清LEP与PINP呈负相关,与β-CTX、BGP无关;Logistic回归分析显示BMI、HbA1c、25(OH)D、LEP、PINP与β-CTX均是绝经后T2DM患者合并骨质疏松的独立危险因素。结论血清25(OH)D水平的降低及LEP水平的升高,可能共同参与了绝经后T2DM女性患者OP的发生发展。     

2型糖尿病视网膜病变合并骨质疏松患者血清25(OH)D与Betatrophin的关系

目的探讨2型糖尿病视网膜病变(type 2 diabetes mellitus retinopathy,T2DR)合并骨质疏松(osteoporosis,OP)患者血清25羟维生素D[25-hydroxy vitamin D,25(OH)D]与Betatrophin之间的关系。方法选取2016年11月-2017年9月在我院内分泌科就诊的2型糖尿病(Type 2 Diabetes Mellitus,T2DM)患者100例,通过非散瞳眼底检查将T2DM患者分为并发DR组35例和非DR组65例,再据骨密度测定结果将DR组分为合并骨质疏松组(T2DM+DR+OP组)15例及非骨质疏松组(T2DM+DR组)20例,将非DR组分为合并骨质疏松组(T2DM+OP组)25例及非骨质疏松组(T2DM组)40例。同期随机筛选健康体检中心不同年龄健康受试者60例为正常对照(normal control,NC)组。酶联免疫吸附(ELISA)法测定所有受试者血清中Betatrophin水平,电化学发光法测定25(OH)D水平。结果与非骨质疏松的2型糖尿病视网膜病变患者相比,合并骨质疏松的2型糖尿病视网膜病变患者血清25(OH)D水平降低,Betatrophin水平升高,差异具有统计学意义(P0.05)。结论血清中25(OH)D水平降低及Betatrophin水平升高,可能共同参与了2型糖尿病视网膜病变、骨质疏松的发生发展。     

c-src/NADPH氧化酶1/活性氧对中性粒细胞弹力蛋白酶诱导气道黏蛋白5 AC表达的影响

目的 探讨中性粒细胞弹力蛋白酶(NE)诱导气道黏液高分泌的上游信号调节机制.方法 体外培养人气道BEAS-2B上皮细胞,将细胞分为空白对照组(不加任何刺激)、NE组(NE刺激)、NE+PP2组(NE刺激合并c-src抑制剂PP2)、NE+c-src siRNA组(NE刺激合并c-src siRNA)、NE+Noxl siRNA组[NE刺激合并NADPH氧化酶1(Nox1)siRNA]、阴件siRNA对照组(加入阴性对照siRNA)及NE+阴性siRNA组(NE刺激合并阴性对照siRNA)为干预条件.检测干预前后各组细胞巾活性氧含量、NoxI蛋白含量、黏蛋白5AC的蛋白及mRNA水平.用四甲基偶氮唑盐法测定各组细胞活性;活性氧试剂盒测定活性氧相对含量;逆转录PCR法检测各组黏蛋白5AC mRNA水平;ELISA法分析细胞黏蛋白5AC的蛋白相对含量;Western blot法检测Noxl蛋白及c-src蛋白的相对含量.结果 NE组细胞中Nox1蛋白相对含量为0.88±0.12,高于空白对照组的0.32±0.09(t=9.12.P=0.003);活性氧相对含量为0.76±0.09,高于空白对照组的0.18±0.02(t=9.44,P=0.003);黏蛋白5AC蛋白相对含量为0.82±0.09,基因转录水平为0.77±0.05,均高于空白对照组(分别为0.21±0.11和0.18±0.08,t值分别为7.75和6.13,P值分别为0.004和0.006).NE+c-src siRNA组细胞的Nox1蛋白相对含最(0.39±0.08)、活性氧相对含量(0.29±0.05)均低于NE组(t值分别为5.43和5.60,均P=0.007);黏蛋白5AC蛋白相对含量(0.38±0.09)及mRNA水平(0.41±0.04)低于NE组(t值分别为5.28和4.09,P值分别为0.008和0.034).NE+PP2组活性氧相对含量为0.41±0.11,Nox1蛋白相对含量为0.44±0.05,黏蛋白5AC蛋白及mRNA水平分别为0.48±0.08和0.46±0.07,均低于NE组(均P<0.05).NE+Noxl siRNA组中活性氧相对含量(0.19±0.06)、黏蛋白5AC蛋白相对含量(0.31±0.05)及mRNA水平(0.32±0.06)也低于NE组(均P<0.05).结论 c-src/Noxl参与了NE诱导的活性氧活化,是气道上皮细胞黏蛋白5AC合成及分泌的上游信号调节因子.     

正确理解偏瘫 提高护理质量

<正>随着科学技术的发展和医疗保健水平的不断提高,人类的平均寿命明显延长。目前,我国老龄人口已经达到1.85亿。随之而来的慢性病发病率升高,偏瘫患者的增多已成为医学和护理学的新挑战。偏瘫患者的病程长,患病后容易出现功能障碍,失去生活自理能力,进而导致焦虑、抑郁等精神问题。护理人员一方面要学习老年护理的专业知识和技能,另一方面也是很重要的一点,是转变护理观念。医疗上的护理不等同于单纯的疾病护理,生活护理也不是让患者吃饱、穿     

“坐起生活”在预防压疮方面的重要意义

<正>压疮是指因长时间一个姿势卧床,营养不良或不洁,导致身体的某一部位血液供应不足而造成皮肤及肌肉的损伤状态。起初压疮易发部位皮肤只是变红。若用手指压也不变白,就是危险信号。如果这个时期仍任其卧床不起,就会导致皮肤破损、溃烂,身体衰弱,有时还会诱发其他疾病(吸入性肺炎等)。