急性外伤性颅内血肿非手术治疗

由于CT脑扫描在神经外科临床应用,对急性内颅血肿能及时诊断,一经确诊,既往多采用手术疗法,近年来应用非手术治疗在国内、外有所报道,但其适应症还不够明确。我们从1984年以来,对急性颅内血肿122例(其中沈阳市一院62例,无锡市一院30例,抚顺矿务局总医院30例),采用非手术疗法,取得较好效果,报道如下。 临床资料 1.一般资料:男91例,女31例。男与女之比3:1。年龄最小6个月,最大76岁,其中小于15岁18例,20～59岁93例,60岁以上10例。全组病例均经CT     

儿童颅内蛛网膜囊肿

儿童颅内蛛网膜囊肿并非罕见,尤其是CT在临床应用以来,国内外有所报告,我们近4年间共收治9例(其中包括中国医科大学3例)。1例经脑血管造影诊断,余8例经CT脑扫描确诊,经手术治疗,取得较好效果,报告如下。 临床资料本组9例,年龄为3～14岁,男6例,女3例,原发性8例(左侧5例、右侧2例、双侧1例),继发性1例。其发病方式,原发性自幼都被家人发现头部颞侧有隆起,但以此就医仅1例,以癫痫大发作就医5例、颅内压增高1例、一侧肢体轻瘫1例,其中伴有智力低下2例,垂体瘤手术后继发1例,以双目失明入院。查体原发性除有颞部隆起外,有阳性体征仅2例,1例双眼外展受限、视乳头边界不清,另1例对侧肢体肌力Ⅱ级、Babinski(+),继发性双眼光感消失、双视乳头苍白。     

Prognostic value of postoperative stimulated thyroglobulin levels on 131Ⅰ ablation therapy in papillary thyroid cancer

Objective Stimulated thyroglobulin (Tg) levels postablation was associated with disease recurrence in papillary thyroid cancer (PTC). The aim of this study was to evaluate the prognostic value of postoperative stimulated Tg level on future Tg positivity after 131Ⅰ ablation therapy in PTC. Methods One hundred and thirty-eight patients (28 men, 110 women; age range 6-70 years, mean age 39.4 years) with PTC were included in this study. All patients underwent total or near-total thyroidectomy, and 102 of these patients had lymphadenectomy. All patients had a documented PTC. 131Ⅰ ablation was performed in 3- 4 weeks after thyroidectomy. Sera levels of thyroid hormones (FT3, FT4), thyrotropin (TSH), anti-Tg anti-body (TgAb), and Tg were measured before and after 131Ⅰ ablation. Statistical analysis was performed with SPSS 13.0 software, and correlation anaysis and t-test were used. Results Postoperative stimulated Tg lev-el had a significantly positive association with pestablation stimulated Tg level (r = 0. 960, P < 0.01). Postoperative stimulated Tg level in positive postablation Tg group was significantly higher than that in nega-tive pestablation Tg group [(199.8±327.7) μg/L vs (3.5±5.6) μg/L, t =5. 567, P <0.01]. About 76% (78/102) patients had evidence of metastatic cervical lymph nodes on routine histological testing. And 41% (446/1088) resected lymph nodes were histologically positive for metastatic disease. The number of metastatic lymph nodes resected had a significantly positive relationship with stimulated Tg at pestopera-tion and postablation (r = 0. 697, 0. 633, both P < 0.01). Conclusions Postoperative stimulated Tg level was of better prognostic value on stimulated Tg level after 131Ⅰ ablation therapy. Total or near-total thyroidec-tomy simultaneously conjugated with lymphadenectomy might have a better result in lower postablation stimu-lated Tg pesitivity in patients with PTC.     

Prognostic value of postoperative stimulated thyroglobulin levels on 131Ⅰ ablation therapy in papillary thyroid cancer

Objective Stimulated thyroglobulin (Tg) levels postablation was associated with disease recurrence in papillary thyroid cancer (PTC). The aim of this study was to evaluate the prognostic value of postoperative stimulated Tg level on future Tg positivity after 131Ⅰ ablation therapy in PTC. Methods One hundred and thirty-eight patients (28 men, 110 women; age range 6-70 years, mean age 39.4 years) with PTC were included in this study. All patients underwent total or near-total thyroidectomy, and 102 of these patients had lymphadenectomy. All patients had a documented PTC. 131Ⅰ ablation was performed in 3- 4 weeks after thyroidectomy. Sera levels of thyroid hormones (FT3, FT4), thyrotropin (TSH), anti-Tg anti-body (TgAb), and Tg were measured before and after 131Ⅰ ablation. Statistical analysis was performed with SPSS 13.0 software, and correlation anaysis and t-test were used. Results Postoperative stimulated Tg lev-el had a significantly positive association with pestablation stimulated Tg level (r = 0. 960, P < 0.01). Postoperative stimulated Tg level in positive postablation Tg group was significantly higher than that in nega-tive pestablation Tg group [(199.8±327.7) μg/L vs (3.5±5.6) μg/L, t =5. 567, P <0.01]. About 76% (78/102) patients had evidence of metastatic cervical lymph nodes on routine histological testing. And 41% (446/1088) resected lymph nodes were histologically positive for metastatic disease. The number of metastatic lymph nodes resected had a significantly positive relationship with stimulated Tg at pestopera-tion and postablation (r = 0. 697, 0. 633, both P < 0.01). Conclusions Postoperative stimulated Tg level was of better prognostic value on stimulated Tg level after 131Ⅰ ablation therapy. Total or near-total thyroidec-tomy simultaneously conjugated with lymphadenectomy might have a better result in lower postablation stimu-lated Tg pesitivity in patients with PTC.     

Prognostic value of postoperative stimulated thyroglobulin levels on 131Ⅰ ablation therapy in papillary thyroid cancer

Objective Stimulated thyroglobulin (Tg) levels postablation was associated with disease recurrence in papillary thyroid cancer (PTC). The aim of this study was to evaluate the prognostic value of postoperative stimulated Tg level on future Tg positivity after 131Ⅰ ablation therapy in PTC. Methods One hundred and thirty-eight patients (28 men, 110 women; age range 6-70 years, mean age 39.4 years) with PTC were included in this study. All patients underwent total or near-total thyroidectomy, and 102 of these patients had lymphadenectomy. All patients had a documented PTC. 131Ⅰ ablation was performed in 3- 4 weeks after thyroidectomy. Sera levels of thyroid hormones (FT3, FT4), thyrotropin (TSH), anti-Tg anti-body (TgAb), and Tg were measured before and after 131Ⅰ ablation. Statistical analysis was performed with SPSS 13.0 software, and correlation anaysis and t-test were used. Results Postoperative stimulated Tg lev-el had a significantly positive association with pestablation stimulated Tg level (r = 0. 960, P < 0.01). Postoperative stimulated Tg level in positive postablation Tg group was significantly higher than that in nega-tive pestablation Tg group [(199.8±327.7) μg/L vs (3.5±5.6) μg/L, t =5. 567, P <0.01]. About 76% (78/102) patients had evidence of metastatic cervical lymph nodes on routine histological testing. And 41% (446/1088) resected lymph nodes were histologically positive for metastatic disease. The number of metastatic lymph nodes resected had a significantly positive relationship with stimulated Tg at pestopera-tion and postablation (r = 0. 697, 0. 633, both P < 0.01). Conclusions Postoperative stimulated Tg level was of better prognostic value on stimulated Tg level after 131Ⅰ ablation therapy. Total or near-total thyroidec-tomy simultaneously conjugated with lymphadenectomy might have a better result in lower postablation stimu-lated Tg pesitivity in patients with PTC.     

生理因素对纹状体多巴胺D2受体表达的影响

为了研究大鼠的品系，和年龄相关的体重因素对纹状体多巴胺Ｄ２受体表达的影响，用大鼠纹状体和＾１、２５Ｉ－ＩＢＺＭ｛（Ｓ）－３－碘－２－羟基－６－甲氧基－Ｎ－「（１－乙基－２－吡咯烷基）甲基」苯甲酰胺｝结合，按照大鼠的品系，性别和年龄相关的体重进行组间配对比较。结果；大鼠的品系和性别对纹状体多巴胺Ｄ２受体的＾１２５Ｉ－ＩＢＺＭ结合无明显影响，但纹状体多巴胺Ｄ２受体的＾１２５Ｉ－ＩＢＺＭ结合却有体重相关     

江苏省血吸虫病疫情监测与风险评估系统的研究II东台市螺情监测方式与效果

目的 目的 探讨血吸虫病传播阻断地区螺情监测的方式, 为螺情监测工作提供新模式。方法 方法 选择苏北沿海达到 血吸虫病传播组断的东台市, 采用村级普查、 村级抽样调查、 市镇重点环境调查和群众报螺4种螺情监测方式, 并采用设 置质控螺点进行质量评估, 分析比较不同螺情监测方式的效果与费用。结果 结果 2008-2013年东台市共监测调查环境 163 079处, 面积22 785.62 hm2 , 发现8个残存螺点, 钉螺面积1.48 hm2 。村级普查、 村级抽样调查和市镇重点环境调查3 种方式分别调查环境94 550、 45 033处和23 496处, 占57.98%、 27.61%和14.41%, 查出有螺环境2、 0处和6处, 螺点环境 查获率0.21个/万、 0和2.55个/万, 市镇重点环境调查螺点查获率显著高于村级普查 （χ2 = 19.158, P = 0.000）。3种方式 质控螺点回收率分别为52.56%、 38.27%和73.62%, 市镇重点环境调查质量显著优于村级查螺 （χ2 = 111.597、 85.991, P 均 = 0.000）。6年接受群众报螺289人次, 共报可疑有螺环境279个, 各类活螺1 501只, 未发现钉螺。6年村级普查、 村级抽 样调查、 市镇重点环境调查分别投入费用161.75万、 94.67万元和52.77万元, 单位面积查螺费用分别为129.88、 133.60元/ hm2 和162.57元/hm2 ; 村级普查和市镇重点环境调查查出每个螺点的费用为80.88万元/处和8.80万元/处, 差异有统计学 意义 （t = 12.850, P = 0.000）, 后者费用为前者的10.88%。结论 结论 市镇重点环境调查查螺方式效率高、 质量好, 可作为传 播阻断地区螺情监测的优选方式之一。     

多巴胺受体显像半定量参数的探讨

目的探讨脑多巴胺受体显像中作为纹状体非特异性摄取的参照区。方法用大鼠体内研究资料，比较额叶皮质和小脑作为纹状体非特异性摄取参照区所获得的纹状体特异性结合１２５Ｉ（ｓ）（－）３碘２羟基６甲氧基Ｎ〔（１乙基）２吡咯烷基）甲基〕苯甲酰胺（ＩＢＺＭ）的结果。结果碘标记ＩＢＺＭ呈立体选择性和可逆性地与纹状体多巴胺Ｄ２受体结合。额叶皮质和小脑显示对配体的快速摄取和洗脱。当用小脑摄取作为纹状体非特异性摄取参照时，未能获得ＩＢＺＭ的饱和性，而用额叶皮质作为参照区时，可证实其可饱和性，Ｂｍａｘ＝４４ｐｍｏｌ／ｇ纹状体组织。Ｈａｌｏｐｅｒｉｄｏｌ的置换率和由大剂量ｓｐｉｐｅｒｏｎｅ或ｈａｌｏｐｅｒｉｄｏｌ竞争性抑制实验衍变而来的纹状体和其他脑区之间摄取差值百分率均提示：小脑摄取低估了纹状体的非特异性摄取，额叶皮质是一个合适的纹状体非特异性摄取参照区。结论在纹状体多巴胺Ｄ２受体显像中，特异性ＩＢＺＭ的结合和其他半定量参数的计算，最好选用额叶皮质作为非特异性结合参照区。