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Monoclonal antibodies (Lc86a-C5, Lc86a-H8) directed against human lung adenocarcinoma cell line LTEP-a-2 and normal BALB/c IgG were labelled with iodine-131 by chloramine T. The 131I-McAbs and 131I-IgG were respectively injected into the peritoneal cavities of nude mice bearing transplanted human lung adenocarcinoma cell line LTEP-a-2. After 72 h, the tumor tissue in nude mice injected with 131I-McAbs was distinguishable from normal tissues as a very clear image obtained during gamma scintigraphy. No difference was found between tumor and normal tissues in the nude mice injected with 131I-IgG. The tumor: blood ratio was 3.1:1 in nude mice injected with 131I-McAb(H8) and 0.9:1 in nude mice injected with 131I-IgG respectively. This indicates that the tumor tissue image was the result of specific binding of the 131I-McAbs, which have high specificity and affinity both in vitro and in vivo, to tumor cells, and these monoclonal antibodies may serve as potential agents in tumor diagnosis and treatment. 相似文献
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Nude mice bearing humor lung cancer xenografts were injected intravenously or intraperitoneally with a mixture of radioiodinated anti-lung-cancer monoclonal antibodies, 2E3 and 6D1. The blood radioactivity versus time curve was fitted to a two-compartment open model with a 3.4 day blood radioactivity clearance half-life and a 636 ml/kg apparent distribution volume. Radioiodinated 2E3 and 6D1 given intraperitoneally were rapidly absorbed, with a 2.08 absorption half-life and 89% bioavailability. The highest radioactivity levels were found in the tumor, blood, liver and spleen 1-3 days after injection; next came the lung, kidney, stomach and intestine. The relative radioactivity increased in the tumor as levels in blood and normal tissues decreased. The in vivo deiodination of radioiodinated 2E3 and 6D1 was about 18.6% and free radioiodine was excreted in the urine. 相似文献
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卵巢癌病人肠梗阻的处理较为困难,术后并发症和死亡率高.有人认为,肠梗阻校正术后患者生存2个月以上就说明治疗有效.据此,另有人提出一个预后评分系统.本研究的目的是分析卵巢癌病人肠梗阻术后的并发症,死亡率和生存有关的因素.并对上述评分系统进行评价.病人:本组49例病人均诊断为卵巢上皮癌.其中30例是小肠梗阻,16例结肠梗阻,3例混合型梗阻,全部经手术治疗.24例(49%)有严重术后并发症,7例(14%)于术后30天内死亡;36例(73%)术后生存2个月以上,平均生存期为170天,其中至少7例存活1年以上.分析这些病人术前、术中和术后 相似文献
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恶性肿瘤是目前威胁人类健康和生命的主要疾病之一,人们一直在探索着新的诊断途径和方法。近年来,采用放射性核素标记的单克隆抗体(McAb),进行体内肿瘤放射免疫显像(Radioimmunoimaging RH)取得了可喜进展。 放射性核素标记的McAb具备两种属性:一是放射性核素在自发衰变过程中,产生射线 相似文献
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人们一期直望能用简单快速而且结果准确的床边试验诊断急性胰腺炎.几个研究表明,快速测定淀粉酶试验(Rapignost-Amylase test,简称快速测定法)的灵敏度高,特异性强.本文将血清淀粉酶测定结果与这种方法的结果进行比较,以估计其临床价值.方法: 按比色原理,用于快速测定法的纸条能测定尿淀粉酶增加,纸条的紫色深度与标准色谱图比较,结果分为3级,正常(-),轻度增加(+),明显增加 相似文献
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