Expression of Resistin mRNA in Adipose Tissue of Rat Model with Polycystic Ovarian Syndrome and Its Implication

Polycysticovarysyndrome(PCOS),oneofthemostcommondisordersinpremenopausalwomen,involvesmenstrualdisturbance,chronicanovulation,andhyperandrogenism.WomenwithPCOSarefrequentlyinsulinresistant(IR),andhavehyperinsulinemia.Althoughithasbeendifficulttoevaluateth…     

多囊卵巢综合征患者卵泡液瘦素水平变化及对卵细胞受精率、卵裂率的影响

目的:探讨体外受精-胚胎移植(IVF-ET)周期中多囊卵巢综合征(PCOS)患者卵泡液瘦素水平变化及对卵细胞受精率、卵裂率的影响。方法:留取行IVF-ET治疗的PCOS患者(PCOS组,n=32例)和因输卵管因素不孕妇女(对照组,n=32例)的卵泡液,利用ELISA法和RIA法分别测定卵泡液瘦素浓度和内分泌指标,观察并记录两组卵细胞受精率、卵裂率。结果:①两组卵泡液瘦素与睾酮水平呈正相关(r=0.444,P<0.01);②PCOS组卵泡液瘦素水平明显高于对照组(P<0.01);③PCOS组卵细胞受精率、卵裂率明显低于对照组(P<0.01)。结论:PCOS患者卵泡液瘦素水平增高对卵细胞受精率、卵裂率有影响,可能是其IVF-ET妊娠成功率低的原因之一。     

PCOS与胰岛素抵抗研究进展

多囊卵巢综合征 (polycysticovarysyndrome ,PCOS)是妇科内分泌常见疾病 ,由于其生化特征、临床表现及发病机理的异质性而成为妇科内分泌领域最复杂的研究热点。近年来 ,许多代谢方面的研究都表明PCOS患者存在胰岛素抵抗 ,成为PCOS的重要发病原因。胰岛素抵抗是一种异常的病理生理状态 ,不但影响到排卵与生育 ,而且还与肥胖、糖尿病和高血压等疾病密切相关。因此 ,成为人们关注的研究热点     

Study of Androgen and Androgen Receptor in Relation to Insulin Resistance in Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) is the mostcommon endocrinopathies of premonopausal womenwith the incidence rate being5 % to2 1 % [1,2 ] .Thedisorder is characterized by anovulation,hyperandro-genism,hyperinsulinism and obesity.Many studiessuggested that insulin resistance play an importantrole in the pathogenesisof PCOS,butthere wasveryfew investigations about androgen and androgen re-ceptor in relation to insulin resistance.The purposeof this study was to investigate the role of serum an…     

Expression of Apoptosis and Inducible Nitric Oxide Synthase in Trophoblastic Cells in Early Spontaneous Abortion

The pregnant immune,especially the function of placenta barrier has been thefocus of recent study in this field.Placenta,as an immune organ,produces a lageamountof activated molecule and isregulated by neural- immune- endocrinenetworks.Butwhat is more importantis thatplacenta actas a barrier to protectthe fetus frommaternal infection or immune challenge.Syncytiotrophoblast has been confirmed tobe the key to the barrier' s function.With its dysfunction,the possibility ofpenetration of the barri…     

早孕期绒毛细胞短期培养的染色体脆性位点研究

筛选102份人工流产的绒毛标本,分组进行短期培养及染色体脆性位点(FS)的研究,结果表明:M199加MTX(终浓度4×10~(-8)mol/L)(2组)与单纯199(1组)比较,染色体畸变率(CAR)和脆性位点表达率(FR)差别均有显著意义(P<0.05);M199加Brdu(终浓度2×10~(-4)mol/L)(3组)与2组比较FR差别有极显著意义(P<0.01);RPMI1640加MTX(终浓度8×10-8mol/L)(4组)与2组比较中期分袭相数差别有极显著意义(P<0.05)。该项技术对探讨群体的遗传素质和对该群体的生活环境质量进行评价具有重要意义,为早孕期产前诊断提供了有效方法。     

克氏综合征一例

克氏综合征(Klinefelter综合征)是男性性腺功能低下疾病。1242年Klinefelter首先报道其特征是有男性表型,小睾丸、无精子,乳腺增生肥大,促性腺激素排量增加。1959年Jacob等发现患者的染色体组型为47,xxy型。目前把这一有y的染色体异常系统分为xxy型,约占80％;xy/xxy等嵌合型约占10％;其它罕见的xxyy等型约占10％。各型的临床表现大同小异,现将我组所见的1例47,xxy型报告如下:     

Study on the Expression of Fas Ligand on the Surfaces of Human Cytotrophoblasts in Normal Pregnancy

The fetus represents a foreign entity to the maternal immune system, yet this nature allograft is notnormally rejected. This unique situation is alwaysconcerned closely by immunologists and organ transplantation workers. Following the deepgoing of thestudy on the mechanisms of immune tolerance, it wasfound that specific activated T cell apoptosis inducedby Fas/Fas ligand (FasL) played an important role inperipheral immune tolerance. The major reason whysome immune--privileged organs such as …     

舒适护理在冠状动脉介入治疗患者中的应用

目的探讨舒适护理在经皮冠状动脉介入治疗(PCI)患者中的护理效果,总结护理经验。方法将180例PCI患者随机分成观察组(90例)和对照组(90例)。对照组的患者实施常规的护理,观察组患者应用舒适护理措施进行服务,并对两组患者的护理疗效进行对比。结果两组并发症发生率、平均住院时间、舒适度对比,观察组明显高于对照组,差异明显有统计学意义(P〈0.05)。结论给予患者舒适护理能够有效提高患者的舒适度,并可减少患者的住院治疗时间,降低并发症的发生几率,值得临床推广应用。