中西医结合治疗眼部带状疱疹及其动态护理的临床观察

目的 探讨中西医结合及动态护理对眼部带状疱疹的治疗作用。方法 用中药龙胆泻肝汤加减结合糖皮质类固醇、联合应用抗生素及病毒唑、实行动态护理。结果 治愈率为91．8％，有效率为100％。与单纯用西药治疗的40例对照组(治愈率为45．0％，有效率为75％)比较，有显性差异。结论 中西医结合治疗眼部带状疱疹，结合动态护理，可缩短病程，减少并发症的发生。     

微量耳垂全血β_2微球蛋白放射免疫测定法

近年来,测定血清中β_2微球蛋白的含量作为肾功能的诊断,肾移植排斥反应的早期监护,肿瘤标记物及其预后的估计,自身免疫病和炎症的诊断,日益受到人们的重视,有的已将血清β_2—MG测定列为肾功能和肾移植排斥反应早期监护的常规检查。 本文报道微量耳垂全血β_2—MG的测定法,并对耳垂全血与静脉血清β_2—MG含量进行比较。     

B超在枯萎孕囊中临床诊断

超声检查是目前临床上诊断胚胎停育(枯萎卵)的最有价值的方法之一，其准确率达90～98％。我站1998年10月～2002年12月B超诊断枯萎孕囊180例，均经手术(刮宫术)证实。现分析如下：     

中药胎儿安方治疗抗心磷脂抗体阳性致滑胎36例

中药胎儿安方用活血化瘀药为主 ,补肾益气药为辅 ,治疗抗心磷脂抗体阳性致滑胎 36例 ,治愈 31例占 83%。提示本方对抗心磷脂抗体阳性有转阴作用 ,可能有促进胎盘微循环 ,增加胎盘血量 ,提高免疫功能达到保胎的作用。     

不同时间给予转化生长因子β对兔骨折愈合作用的研究

目的 探讨不同时间给予外源性TGF—β对骨折愈合的促进作用。方法 采用兔右尺骨骨折模型，在不同作用时间于骨折区局部注射TGF-β，观察骨折愈合后生物力学、骨痂面积、皮质骨厚度和哈佛氏管直径的变化。结果 不同时间段给予TCF—P各组的骨痂面积和最大抗弯强度均有明显增加。不同给予时间的作用效果不同，在骨折后3～13d局部注射TGF—β的作用最强，TGF-β对愈合骨的极限应力、刚度、极限负荷时能量吸收、皮质骨厚度和哈佛氏管直径则没有影响。结论 外源性TGF—β促进骨折愈合具有时效作用，在膜内成骨期局部应用时作用明显。     

The effect of curcumin on mismatch repair (MMR) proteins hMSH2 and hMLH1 after ultraviolet (UV) irradiation on HL-60 cells

Summary To understand the expression and effect of mismatch repair genes, hMSH2 and hMLH1, and to investigate anti-leukemic cell proliferation mechanism of curcumin, the levels of both genes were detected by multiple comparative RT-PCR. The protein of hMSH2 was determined by flow cytometry (FCM) and the gene mutation of hMSH2 and hMLH1 were detected by PCR-SSCP and microsatellite instability assay. After UV irradiation, the gene expression of hMSH2 and hMLH1 was not increased and showed no response. This phenomenon was not ascribed to gene mutation, because PCP-SSCP and microsatellite instability assay revealed no abnormal gel-shift band in both genes. After irradiation and addition of curcumin, the expression of hMSH2 mRNA increased and the cellular apoptotic rate also increased at the same time. The difference was statistically significant as compared with groups without addition of curcumin and control groups (P<0.05). Our results suggested that when MMR system was inhibited by the same agents, curcumin can remove this suppression and switch to cellular apoptosis. CHEN Yan, male, born in 1952, Professor This project was supported by a grant from the National Natural Sciences Foundation of China (Serial No. 39770934).     

马斯洛需要层次理论在改善医患关系中的应用

2003年全国一、二、三级医院发生的医疗纠纷比2002年普遍上升，其中三级医院上升17．9％，二级医院上升34．7％，一级医院上升12．9％。当前医疗过程中医患各方的需要未被全面认识、关注和满足，是医疗纠纷不断攀升的重要原因之一。     

婴儿腹泻继发急性肠套叠的早期诊断

为了加强儿科临床对婴儿腹泻继发急性肠套叠的警惕性，减少手术率及并发症的发生率，结合本组病例，对婴儿腹泻继发急性肠套叠的早期诊断进行分析和探讨。本院儿科1990～2003年4年收治的婴儿腹泻继发肠套叠6例，其中3例发生肠坏死、腹膜炎，均转外科手术治愈。     

The Effect of Curcumin on Mismatch Repair(MMR) Proteins hMSH2 and hMLH1 after Ultraviolet(UV) Irradiation on HL-60 Cells

To understand the expression and effect of mismatch repair genes, hMSH2 and hMLH1,and to investigate anti-leukemic cell proliferation mechanism of curcumin, the levels of both geneswere detected by multiple comparative RT-PCR. The protein of hMSH2 was determined by flow cy-tometry (FCM) and the gene mutation of hMSH2 and hMLH1 were detected by PCR-SSCP and mi-crosatellite instability assay. After UV irradiation, the gene expression of hMSH2 and hMLH1 wasnot increased and showed no response. This phenomenon was not ascribed to gene mutation, becausePCP-SSCP and microsatellite instability assay revealed no abnormal gel-shift band in both genes. Af-ter irradiation and addition of curcumin, the expression of hMSH2 mRNA increased and the cellularapoptotic rate also increased at the same time. The difference was statistically significant as comparedwith groups without addition of curcumin and control groups (P<0.05). Our results suggested thatwhen MMR system was inhibited by the same agents, curcumin can remo     

皮肤粘膜淋巴结综合征——附7例报告

皮肤粘膜淋巴结综合征[MucocutaneousLymph Node Syndrome,简称 MCLS)是一种原因不明的发热性出疹性疾病,1967年日本川崎(Kawasaki)首先报导,故称川崎病。本病分布地区很广,有日本、美国、希