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Ma?gorzata Pawelec-Wojtalik Ludwig Karl von Segesser Ma Liang Dorota Bukowska 《European journal of cardio-thoracic surgery》2005,27(4):714-716
Growing experience in interventional cardiology leads to the use of large diameter of vascular equipment. In some instances, the so-called hybrid procedures are performed. After performing the interventional procedure, the opening in ventricular wall is closed surgically. Our intention was to check if the MVSDO can be used to close the perforation in the heart after the interventional cardiology procedure performed through the left ventricular (LV) free wall. In three pigs under general anesthesia, the heart was exposed through a small substernal incision. The LV was punctured and an 18F sheath was introduced into the LV. A 14 mm MVSDO was inserted through the 10F Delivery System. Using both the echocardiographic and angiographic guidance, the MVSDO was placed on the LV wall to close the opening in the LV. Time and volume of bleeding was recorded. In all cases the occluder was successfully placed closing the opening, bleeding observed after deployment of occluder lasted for approximately 2 min. We think MVSD occluder can be used to close the LV free wall perforation after hybrid interventional cardiac procedure. Early bleeding through MVSDO might be resolved by the manufacturing of new occluder with better sealing properties. 相似文献
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55.
F J von Baumgarten G Burkhard D Englert P Kraus H G Mertens G Müller-Berghaus H Przuntek 《European neurology》1987,27(3):149-154
Fibrinopeptide A (FPA), platelet-secreted protein, platelet factor 4 and beta-thromboglobulin were determined in the cerebrospinal fluid of patients who had suffered from subarachnoid hemorrhage and were treated with 6 g tranexamic acid or 4 million KIU aprotinin to prevent rebleeding. Platelet-secreted proteins and FPA were cleared from the cerebrospinal fluid within 3 days after bleeding. Their vasoactive and thrombotic capability is limited to the initiation period of vasospasm that usually comes to clinical observation 3-8 days after bleeding. Increased thrombotic activity of the cerebrospinal fluid, as reflected by high levels of FPA and platelet-secreted protein, seemed to promote the occurrence of neurological deficits. 相似文献
56.
Apolipoprotein E isoforms were determined in 139 unrelated patients with retinitis pigmentosa (RP). When compared to prevalence rates for the general population in Germany, an increased prevalence was observed for phenotypes E2/E2: 10.1 vs. 1.0% (p less than 0.001), E2/E3: 19.4 vs. 12.0% (p less than 0.05), and E2/E4: 5.8 vs. 1.5% (n.s.), while the prevalence appeared to be reduced for phenotypes E3/E3: 48.9 vs. 59.8% (n.s.) E3/E4: 13.7 vs. 22.9% (p less than 0.05), and E4/E4: 2.2 vs. 2.8% (n.s.). These findings suggest that genetically determined abnormalities of plasma lipoprotein metabolism may be associated with some forms of RP. 相似文献
57.
Mario von Depka Murtada Hassan Jan Blatn? Petr Smejkal Vladimir Vdovin 《Blood coagulation & fibrinolysis》2006,17(4):311-316
Spontaneous and surgery-associated bleeding in patients with von Willebrand disease (vWD) cannot always be controlled with desmopressin or replacement therapy. This paper presents results on the use of recombinant-activated factor VII (rFVIIa) in patients with vWD included in the internet registry Haemostasis.com. Twenty-eight reports on the use of rFVIIa in vWD were identified from the database and included in this analysis. The bleeding episodes were classified as mild (n = 7), moderate (n = 16), or severe (n = 2), and were unspecified in three cases. The median dose of rFVIIa administered was 94 microg/kg body weight (40-127.3 microg/kg). Bleeding stopped in 23 of 27 evaluable patients (85%) and markedly decreased in three patients; the total response rate was 96% (26/27 patients). Response did not correlate with the type of vWD, the site or severity of the initial bleed, or the rFVIIa dose. Other replacement therapies were infrequently used, and their use was similar in the 24 h before and after rFVIIa administration. Eighteen patients also received antifibrinolytic treatment, but its impact on response was not recorded. Only one adverse event (mild fever) was observed. These cases suggest a role for rFVIIa as a safe and effective therapy for vWD. 相似文献
58.
Sibylle von Vietinghoff Wolfgang Schneider Friedrich C Luft Ralph Kettritz 《Nephrology, dialysis, transplantation》2006,21(11):3324-3326
59.
Dr. E. Mietzsch M. Koch M. Schaldach J. Werner B. Bellenberg K. U. Wentz 《Medical & biological engineering & computing》1998,36(6):673-678
The application of spin-echo magnetic resonance imaging sequences on non-invasive temperature imaging for temperature mapping
of human limbs is investigated. In an in vitro expriment performed on a meat sample, the equilibrium magnetisation P and the
spin-lattice relaxation time T1 are calculated from the values for the repetition time TR and the signal intensities obtained by a spin-echo sequence at
different tissue temperatures tures as measured by a fibre-optic probe. T1 is linearly correlated to the tissue temperature, and P is linearly correlated to the reciprocal value of the absolute temperature.
Both effects, taken together, lead to a non-linear dependency of the signal intensity on temperature. Therefore a TR leading
to maximum temperature dependency of the signal intensity is calculated and used in the futher experiments. In the in vivo
experiments, the lower legs of two volunteers are cooled from outside. Images are acquired with a spin-echo sequence (1.5T,
TR=1200 ms, TE=10 ms). A rise in signal intensity in the muscle with falling skin temperature is observed, particularly in
more peripheral muscle layers. This study shows that spin-echo sequences can be used to monitor temperature changes and temperature
differences in living muscle tissue. 相似文献
60.
Back pain in in-vitro fertilized and spontaneous pregnancies 总被引:1,自引:0,他引:1
Kristiansson P; Nilsson-Wikmar L; von Schoultz B; Svardsudd K; Wramsby H 《Human reproduction (Oxford, England)》1998,13(11):3233-3238
The influence of ovarian stimulation in in-vitro fertilization (IVF) on the
prevalence of back pain with onset during pregnancy was studied in 31 women
who became pregnant after IVF treatment and compared with that of 200
spontaneously pregnant women. A two times higher prevalence rate of sacral
pain in late pregnancy was reported among IVF pregnant women (P <
0.0001), as well as a significantly higher prevalence rate of positive
results of pelvic pain provocation tests performed in late pregnancy
(0.0001 < or = P < or = 0.015), as compared with that of the
spontaneously pregnant women. Among the IVF pregnant women, there was a
significant positive correlation between relaxin concentrations in early
pregnancy and the outcome of pelvic pain provocation tests (0.44 < or =
r < or = 0.51, P < 0.05). In addition, the serum relaxin
concentration was the factor that best explained differences in sacral pain
prevalence. When the influence of serum relaxin concentration on back pain
prevalence was taken into account, women carrying multiple pregnancies had
no more pain than women carrying singletons, and IVF pregnant women had no
more pain than spontaneously pregnant women. These results support the
hypothesis that relaxin is involved in the generation of pelvic pain in
pregnant women.
相似文献