全文获取类型
收费全文 | 19401篇 |
免费 | 1201篇 |
国内免费 | 131篇 |
专业分类
耳鼻咽喉 | 330篇 |
儿科学 | 498篇 |
妇产科学 | 379篇 |
基础医学 | 2789篇 |
口腔科学 | 1669篇 |
临床医学 | 1439篇 |
内科学 | 4106篇 |
皮肤病学 | 453篇 |
神经病学 | 1291篇 |
特种医学 | 582篇 |
外科学 | 2275篇 |
综合类 | 84篇 |
一般理论 | 3篇 |
预防医学 | 2195篇 |
眼科学 | 257篇 |
药学 | 1396篇 |
1篇 | |
中国医学 | 195篇 |
肿瘤学 | 791篇 |
出版年
2023年 | 201篇 |
2022年 | 435篇 |
2021年 | 756篇 |
2020年 | 495篇 |
2019年 | 623篇 |
2018年 | 781篇 |
2017年 | 543篇 |
2016年 | 583篇 |
2015年 | 679篇 |
2014年 | 880篇 |
2013年 | 1068篇 |
2012年 | 1447篇 |
2011年 | 1690篇 |
2010年 | 906篇 |
2009年 | 703篇 |
2008年 | 1108篇 |
2007年 | 1099篇 |
2006年 | 923篇 |
2005年 | 807篇 |
2004年 | 692篇 |
2003年 | 611篇 |
2002年 | 515篇 |
2001年 | 392篇 |
2000年 | 360篇 |
1999年 | 326篇 |
1998年 | 153篇 |
1997年 | 132篇 |
1996年 | 124篇 |
1995年 | 85篇 |
1994年 | 81篇 |
1993年 | 64篇 |
1992年 | 145篇 |
1991年 | 137篇 |
1990年 | 96篇 |
1989年 | 117篇 |
1988年 | 113篇 |
1987年 | 80篇 |
1986年 | 93篇 |
1985年 | 75篇 |
1984年 | 59篇 |
1983年 | 54篇 |
1982年 | 35篇 |
1981年 | 30篇 |
1980年 | 39篇 |
1979年 | 47篇 |
1978年 | 30篇 |
1977年 | 31篇 |
1976年 | 33篇 |
1971年 | 30篇 |
1969年 | 29篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
72.
73.
The effects of clindamycin on polymorphonuclear leukocytes (PMNLs) were evaluated in vitro and in vivo in an experimental model and in immunocompromised patients with and without infection. Chemotaxis, chemiluminescence, and bactericidal capacity were evaluated using PMNLs preincubated with clindamycin in different concentrations. In the three phases of the study, clindamycin at a concentration of 2 mg/L significantly increased PMNL function. In contrast, when higher concentrations were used, PMNL function was not modified and in some cases it was decreased. Our findings suggest that clindamycin, in concentrations of 2 mg/L, positively modifies PMNL function. 相似文献
74.
Andres A; Morales JM; Praga M; Campo C; Lahera V; Garcia-Robles R; Rodicio JL; Ruilope LM 《Nephrology, dialysis, transplantation》1997,12(7):1437-1440
BACKGROUND: Cyclosporin has been shown to facilitate renal vasoconstriction
and to have an antinatriuretic effect. The existence of an interference of
cyclosporin with the vasodilating properties of endothelium mediated by
nitric oxide production could mediate these effects. On the other hand, the
infusion of the nitric oxide precursor L-arginine has been shown to induce
renal vasodilatation and to facilitate natriuresis in normal volunteers. We
have investigated the renal effects of the administration of an infusion of
L-arginine in renal transplant patients chronically treated with
cyclosporin. To facilitate the analysis of the data the effects of the
administration of a similar dose of cyclosporin on renal function during
the infusion of a vehicle were also investigated during the administration
of a vehicle of L-arginine. DESIGN: Ten male renal transplant patients,
chronically treated with cyclosporin and with a stable renal function were
studied during 2 consecutive days after the administration of the usual
morning dose of cyclosporin. The first day they received an intravenous
infusion of vehicle and the second the infusion of graded doses of
L-arginine (50, 100, 150 mg/kg/h) during 3 consecutive h. RESULTS: The
first day, after cyclosporin administration a significant fall (P <
0.01) was observed in natriuresis and kaliuresis in the absence of changes
in renal plasma flow and glomerular filtration rate. After the
administration of L-arginine significant (P < 0.01) increases of renal
plasma flow, glomerular filtration rate, and natriuresis were seen. The
increase in blood levels of cyclosporin after its administration did not
differ between days 1 and 2. CONCLUSION: These results indicate that
L-arginine facilitates renal vasodilatation and natriuresis in renal
transplant patients. Furthermore, the observed increase in sodium excretion
could indicate that L-arginine counteracts the antinatriuretic effect of
cyclosporin.
相似文献
75.
J M González Santos J L Vallejo J C Sevilla K Abukassem P Garrido E Bastida M Riesgo R Fortuny R Arcas 《Revista espa?ola de cardiología》1991,44(10):639-647
We present here the clinical results with a second-generation porcine bioprosthesis, the Carpentier-Edwards supra-annular valve (CESA). Two-hundred and twenty-two CESA bioprostheses were implanted in 189 patients during a four-year period (from 1984 to 1987), either as an isolated procedure or associated to mitral or tricuspid repair. The mid-term clinical results have been evaluated after a mean follow-up of 3.4 years, being 96% complete. There were 16 in-hospital deaths (8.4%) and 6 late, potentially valve-related, cardiac deaths (1.1% patients/year). Overall, 86.7 +/- 2% of the patients were free from cardiac death at 6 years (95.1 +/- 2% of the patients surviving the operative period). Linearized rates of valve related complications were the following: 1.4% patients/year for thromboembolism (including valve thrombosis), 0.5% patients/year for treatment-related hemorrhage and 0.7% patients/year for endocarditis. We did not found any case of either intrinsic or extrinsic valve failure, unrelated to infection of thrombosis. Two patients were reoperated, one because of valve thrombosis and the other due to prosthetic valve endocarditis (reoperation rate of 0.3% patients/year). When lethal and nonlethal valve-related complications (including in-hospital deaths) were considered all together, 75.8 +/- 8.4% of the patients remained alive and free of morbid events at 6 years. When patients were grouped according to the valve replaced (aortic, mitral and multiple), best results were found with patients submitted to isolated aortic valve replacement. We conclude that the CESA bioprosthesis has an excellent mid-term clinical performance. However, longer follow-up is necessary to know if improvement in valve design and manufacturing results in increased valve durability. 相似文献
76.
G C Santos M R Araujo T C Silveira F A Soares 《Archives of pathology & laboratory medicine》1992,116(11):1152-1154
Increased amounts of brown adipose tissue have been reported to occur in association with several diseases. The objective of the present study was to determine whether brown adipose tissue accumulation is related to nutritional status. Histologic sections of periadrenal tissue prospectively obtained at consecutive autopsies from 366 adults were examined. The cases were separated into three groups: malnourished (101 autopsies), normotrophic (128 autopsies), and obese (137 autopsies), according to the Quetelet index. Of these patients, 89 had brown adipose tissue accumulation, 35 were malnourished, 32 were normotrophic, and 22 were obese. The results showed a correlation between brown adipose tissue and patient nutritional status and a higher brown adipose tissue accumulation in malnourished patients. Cardiovascular disease was the most common type of illness present in the cases with brown adipose tissue accumulation. 相似文献
77.
78.
Does altered biomechanics cause marrow edema? 总被引:21,自引:0,他引:21
79.