Development and Validation of Global Leadership Initiative on Malnutrition for Prognostic Prediction in Patients Who Underwent Cardiac Surgery

The Global Leadership Initiative on Malnutrition (GLIM) has achieved a consensus for the diagnosis of malnutrition in recent years. This study aims to determine the prognostic effect of the GLIM after cardiac surgery. A total of 603 patients in the training cohort and 258 patients in the validation cohort were enrolled in this study. Perioperative characteristics and follow-up data were collected. A nomogram based on independent prognostic predictors was developed for survival prediction. In total, 114 (18.9%) and 48 (18.6%) patients were defined as being malnourished according to the GLIM criteria in the two cohorts, respectively. Multivariate regression analysis showed that GLIM-defined malnutrition was an independent risk factor of total complication (OR 1.661, 95% CI: 1.063–2.594) and overall survival (HR 2.339, 95% CI: 1.504–3.637). The c-index was 0.72 (95% CI: 0.66–0.79) and AUC were 0.800, 0.798, and 0.780 for 1-, 2-, and 3-year survival prediction, respectively. The calibration curves of the nomogram fit well. In conclusion, GLIM criteria can efficiently identify malnutrition and has a prognostic effect on clinical outcomes after cardiac surgery. GLIM-based nomogram has favorable performance in survival prediction.     

Effects of Internet-Based Nutrition and Exercise Interventions on the Prevention and Treatment of Sarcopenia in the Elderly

Effective nutrition and exercise interventions may improve sarcopenia in the elderly. The purpose of our study was to investigate the effectiveness of Internet-based nutrition and exercise interventions in the elderly with sarcopenia. Participants were divided into 4 groups: control, nutrition, exercise, and comprehensive (nutrition plus exercise) groups; there was at least 50 participants in each group. Our trial lasted 12 weeks. We conducted dietary and exercise interventions through an app and collected feedback from the participants every three weeks. Information on the diet, skeletal muscle mass, and muscle function was collected before and after the interventions. The comprehensive group had higher high-quality protein intake than the control (p = 0.017) and exercise (p = 0.012) groups. After the interventions, we obtained differences in skeletal muscle mass, skeletal muscle mass/height², skeletal muscle mass/weight, muscle mass/BMI, and skeletal muscle mass/body fat percentage (p < 0.05). Changes in average daily energy and total daily protein intakes were not significantly different; however, there was an overall improvement in the intervention groups relative to baseline data. There were no changes in the average daily time of moderate physical activity. The Internet was an effective tool of nutrition intervention in the elderly with sarcopenia. The Internet-based nutrition intervention improved high-quality protein intake and skeletal muscle mass in the elderly with sarcopenia.     

CBCT影像组学联合构建Nomogram模型预测食管癌放疗患者放射性肺炎

目的:通过对放疗疗程中不同时段CBCT图像的影像组学分析,寻找早期定量预测食管癌放疗放射性肺炎(RP)的参数,结合临床特征和肺剂量体积参数建立联合Nomogram模型并探讨这一模型对食管癌RP的预测价值。方法:回顾分析2017—2019年间临床资料、剂量学参数、CBCT图像资料完整的96例胸中段食管鳞癌调强放疗患者资料...     

建立糖尿病心肌病动物模型方法的实验研究

目的研究建立糖尿病心肌病动物模型的科学、实用的方法。方法应用链脲佐菌素对SD大鼠进行一次性腹腔注射,通过观察大鼠的一般状况、进食量、进水量、尿量、体重的变化,监测血糖、尿糖、心肌酶含量、胰岛素水平、心肌超微结构、心脏大血管内膜情况及心电图情况来评估糖尿病心肌病的发病情况。结果腹腔注射STZ 3周后,模型组大鼠出现病态表现,进食量、饮水量、尿量增加,体重下降。血糖值、尿糖值及肌酸激酶、乳酸脱氢酶值均较对照组大鼠升高。胰岛素水平较对照组明显降低,心肌超微结构符合糖尿病心肌病表现,心脏大血管未见纤维斑块和粥样斑块。结论对SD大鼠进行一次性腹腔注射链脲佐菌素(55mg/kg),大鼠于注射后第3周可出现稳定的糖尿病心肌病状态。这是一种可靠且实用性强的糖尿病心肌病动物模型的制备方法。     

血液透析患者动静脉内瘘自我护理行为现状及影响因素研究

目的 调查血液透析患者动静脉内瘘自我护理行为现状并分析其影响因素,为临床护理干预提供理论依据.方法 采用便利抽样法,选取湖州市某三级甲等医院血液透析行动静脉内瘘患者118例为调查对象,采用一般资料调查表及血液透析患者动静脉内痿自我护理行为量表进行调查,运用单因素分析及多元线性回归分析其自我护理行为影响因素.结果 血液透...     

Development of laminar organization of the fetal cerebrum at 3.0T and 7.0T: a postmortem MRI study

Introduction  

The purpose of this study is to show the condition of laminar organization on 3.0T and 7.0T postmortem magnetic resonance imaging (MRI) and analyze developmental changes.     

山羊颈椎次全切除减压非融合后生物力学特性

目的 探讨山羊颈椎次全切除减压非融合后生物力学特性.方法 选取成年雄性山羊6只造模(模型组),术前行颈椎X线检查,排除骨性结构异常,并测量节段性Cobb角(SCA)和颈椎Cobb角(CCA)于C4行颈椎次全切除术,并植入可动人工颈椎(ACV).术后行颈椎正侧位X线检查,再次测量SCA和CCA.术后6个月处死山羊,并以6...     

复方二氯苯醚菊脂的杀虫试验及毒性试验

复方二氯苯醚菊脂灭蚊剂由二氯苯醚菊脂、巴沙等组成.复方二氯苯醚菊脂剂对蚊、蝇的杀灭效果较好,对人畜毒性较小,是值得推广的一种杀虫剂.     

Effect of Yang-activating and stasis-eliminating decoction from Traditional Chinese Medicine on intestinal mucosal permeability in rats with ulcerative colitis induced by dextran sulfate sodium

Objective

To evaluate the effect of decoction prepared with Yang-activating and stasis-eliminating medicinals from Traditional Chinese Medicine (TCM) on the intestinal mucosal permeability in rats with ulcerative colitis induced by dextran sulfate sodium (DSS).