Effect of auricular point pressing therapy on postoperative pain of fracture: A protocol for systematic review and meta-analysis

Background:In clinical practices, postoperative fracture patients are often treated with analgesics. As one of the alternative therapies for nondrug analgesia, auricular point pressing has advantages of simple operation, easy to use, no injury and adverse reactions, and great potential for development. In this study, the effect of auricular point pressing therapy on postoperative pain of fracture was objectively evaluated through the method of meta-analysis, so as to provide evidence for clinical applications.Methods:PubMed, Web of Science, Cochrane Library, EMBASE, Wan fang Database, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, and Chinese Biomedical Literature Database were systematically searched and randomized controlled trials on auricular point pressing in the treatment of postoperative pain after fracture were includes. After independent literature screening, data extraction and quality evaluation by 2 researchers, the original data was retrieved, merged, and analyzed. RevMan 5.3 software was adopted for meta-analysisResults:This study could provide high-quality evidence to evaluate the effect of auricular point pressing therapy on postoperative pain of fracture.Conclusion:This systematic review explored whether auricular point pressing therapy is effective on the intervention of postoperative pain after fracture.OSF Registration Number:DOI 10.17605/OSF.IO/AZ4JQ.     

Application of Joanna Briggs Institute physical restraint standards to critical emergency department patients following CONSORT guidelines

To explore the effect of Joanna Briggs Institute (JBI) physical restraint standards in improving physical restraint in critical and emergency department patients.Enrolled 300 critical patients admitted in our hospital''s emergency department from January to December 2019: 150 patients admitted January to June 2019 as control group and 150 patients admitted July to December 2019 as observation group. Routine restraints were applied in control group. Emergency department nurses in the observation group received thematic and practical JBI standardized training. This included pre-restraint assessment, principles of physical restraint, informed consent, using a restraint decision-making wheel, and alternatives to physical restraint. The incidence of restraint-associated adverse events (e.g., skin bruising, swelling) and restraint utilization rate were examined between 2 groups.The incidence of adverse events and the restraint utilization rate were significantly lower in the observation group (P < .05).The application of JBI physical restraint standards for emergency department patients can effectively reduce the incidence of adverse events and the restraint utilization rate.     

米那普仑与度洛西汀治疗抑郁症的疗效和安全性评价

目的：比较米那普仑与度洛西汀治疗抑郁症的疗效和安全性评价,为临床治疗抑郁症提供可选择的药物。方法：采用随机对照、度洛西汀开放式6周对照研究。共收集抑郁症患者120例,米那普仑组60例,男37例,女23例,度洛西汀组60例,男33例,女27例,米那普仑初始剂量是50 mg·d^-1（po,bid）,度洛西汀的初始剂量是20 mg·d^-1（po,bid）。主要研究指标为基线到治疗6周后汉密尔顿抑郁量表17项（HAMD-17）总分的变化;次要研究指标汉密尔顿焦虑量表（HAMA）对治疗后患者一般情况进行评价,并应用不良反应量表（TESS）观察试验中不良事件的发生情况。结果：米那普仑组和度洛西汀组治疗6周末,米那普仑组HAMD-17总分下降了（14.56±3.25）,度洛西汀组下降了（14.62±3.19）;在各随访点,HAMD-17总分在2组间无明显差异（P>0.05）;米那普仑组和度洛西汀组的有效率分别为78.33%和76.67%,疗效上无明显差异（P>0.05）;2组HAMA评分无显著差异（P>0.05）;米那普仑组的不良事件发生率为13.33%（8/60）,度洛西汀组为21.67%（13/60）,2组相比有显著差异（P<0.05）。整个研究过程中无严重不良事件发生。结论：米那普仑与度洛西汀治疗抑郁症患者的疗效都有效且耐受性良好;米那普仑出现的相关症状更少。     

Assessment of lung glucose uptake in patients with systemic lupus erythematosus pulmonary arterial hypertension: a quantitative FDG-PET imaging study

Annals of Nuclear Medicine - Pulmonary arterial hypertension (PAH) is a recognized complication of systemic lupus erythematosus (SLE-PAH) patients and its lung pathology shares similarity to...     

The association between the polymorphism rs2231142 in the ABCG2 gene and gout risk: a meta-analysis

Gout is a common metabolic disorder with high heritability. We tried to explore the association between rs2231142 and gout. We searched “rs2231142 or Q141K and gout” in four databases and scholar searching website until 1 June, 2013 and included data from 52,010 participants in meta-analysis and subgroup analysis. The T allele of rs2231142 was associated with increased gout susceptibility (odds ratio [OR] [95 % confidence interval (95 % CI)]?=?1.73 [1.55–1.91], P?P?P?P?Pacific Islanders with OR (95 % CI)?=?2.94 (1.72–4.15), P?P?=?0.061. No publish or other biases were observed. The T allele of rs2231142 was associated with increased risk of gout.     

Monocyte subsets and monocyte-platelet aggregates in patients with unstable angina

Monocyte subsets and monocyte-platelet aggregates (MPAs) play important role in atherosclerosis and thrombosis. We aimed to determine their changes in patients with unstable angina (UA). In this cross-sectional case–control study, Global Registry of Acute Coronary Events (GRACE) score was determined in 95 UA patients without elevated troponin level. Thirty age-and-sex matched stable coronary heart disease (CHD) subjects served as control group. The classical (CD14++CD16?, Mon1), the intermediate (CD14++CD16+, Mon2) and the non-classical (CD14+CD16++, Mon3) monocytes, as well as subset-specific MPAs, were measured by flow cytometry. Compared with stable CHD patients, UA patients had increased Mon2 and Mon3 counts (all P < 0.001). For UA subjects, compared with GRACE score-determined low risk patients (GRACE score ≤108, n = 70), intermediate-to-high risk patients (GRACE score >108, n = 25) had higher counts of Mon2 and total MPAs, as well as Mon1- and Mon2-associated MPAs (all P < 0.001). Adjusted binary logistic regression analysis revealed that increased counts of Mon2 subset (for per 5 cells/μL increase, OR 1.186, 95 % CI 1.044–1.347, P = 0.009), Mon2 MPAs (for per 5 cells/μL increase, OR 1.228, 95 % CI 1.062–1.421, P = 0.006) and total MPAs (for per 5 cells/μL increase, OR 1.072, 95 % CI 1.010–1.137, P = 0.022) independently associated with GRACE score-determined intermediate-to-high risk UA patients. In UA patients with intermediate-to-high risk (determined by GRACE score), counts of Mon2 subset, Mon2-associated MPAs and total MPAs are increased, which are independent of traditional risk factors.     

Magnetic resonance imaging and risk factors for progression of lacunar infarct lesions in Chinese patients

Neuroradiology - The proportion of acute symptomatic lacunar infarction lesions that undergo cavitation and the factors influencing cavity formation are yet unclear, particularly in the Chinese...