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排序方式: 共有826条查询结果,搜索用时 46 毫秒
821.
Fabrizio Romano Marisa Molinaro Susanne Schibli Philipp KA Agyeman Ruth Mari Lllgen 《Clinical Case Reports》2021,9(8)
Jaundice should be considered as a first clinical sign preceding severe invasive bacterial infection or sepsis in patients of all ages including childhood and adolescence. Early laboratory investigations and MR imaging studies for osteomyelitis or myositis are paramount to avoid progression to life‐threatening sepsis and significant morbidity and mortality. 相似文献
822.
Ilham Chaouni Marie-Paule Lefranc Arnaud Dupuy D'Angeac Carole Zanin Florence Pellet Jacques Clot Bernard Combe Jacques Sany THIERRY Rme 《Arthritis \u0026amp; Rheumatology》1992,35(7):756-760
Objective. We sought new susceptibility markers for rheumatoid arthritis (RA) among the T cell receptor γ (TCRγ) genes. Methods. We analyzed restriction fragment length polymorphisms (RFLP) of the first variable subgroup of TCRγ genes in a group of French control subjects and a group of French RA patients. Results. No significant difference in Eco RI RFLP was found between the 2 study populations: Allele frequencies were virtually identical. There was no polymorphism using Hind III. Conclusion. These results exclude TCRV γI polymorphism as a disease susceptibility marker in RA. 相似文献
823.
Andrey Gonçalves Emídio DDS MS Vitória Fraga Fogaça Melo e Silva DDS MS Edgar Pedreiro Ribeiro DDS Gabriela Torres Zanin DDS MS Murilo Baena Lopes DDS MS PhD Ricardo Danil Guiraldo DDS MS PhD Sandrine Bittencourt Berger DDS MS PhD 《Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]》2023,35(2):423-430
824.
825.
Marika Pane Giorgia Coratti Valeria A. Sansone Sonia Messina Michela Catteruccia Claudio Bruno Maria Sframeli Emilio Albamonte Marina Pedemonte Noemi Brolatti Irene Mizzoni Adele D'Amico Chiara Bravetti Beatrice Berti Concetta Palermo Daniela Leone Francesca Salmin Roberto De Sanctis Maria Carmela Pera Marco Piastra Orazio Genovese Federica Ricci Ilaria Cavallina Riccardo Masson Riccardo Zanin Caterina Agosto Eleonora Salomon Irene Bruno Andrea Magnolato Enrico Bertini Francesco Danilo Tiziano Francesca Bovis Eugenio Mercuri the Italian EAP Working Group 《European journal of neurology》2023,30(6):1755-1763
Background
We report the 4-year follow-up in type I patients treated with nusinersen and the changes in motor, respiratory and bulbar function in relation to subtype, age and SMN2 copy number.Methods
The study included SMA 1 patients with at least one assessment after 12, 24 and 48 months from the first dose of nusinersen. The assessments used were Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND) and the Hammersmith Infant Neurological Examination (HINE-II).Results
Forty-eight patients, with ages ranging from 7 days to 12 years (mean 3.3 years, SD 3.6 years) were included in the study. The CHOP INTEND and HINE-II scores significantly increased between baseline and 48 months (p < 0.001). When age at starting treatment subgroups (<210 days, <2 years, 2–4 years, 5–11 years, ≥12 years) were considered, the CHOP INTEND increased significantly in patients younger than 4 years at treatment, while the HINE-2 increased significantly in patients younger than 2 years at treatment. In a mixed-model analysis, age, nutritional and respiratory status were predictive of changes on both scales while SMN2 copy number and decimal classification were not.Conclusions
Our results confirm the safety profile previously reported and support the durability of the efficacy of nusinersen at 4 years with an overall stability or mild improvement and no evidence of deterioration over a long period of time. 相似文献826.