全文获取类型
收费全文 | 8073篇 |
免费 | 394篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 55篇 |
儿科学 | 163篇 |
妇产科学 | 59篇 |
基础医学 | 984篇 |
口腔科学 | 162篇 |
临床医学 | 515篇 |
内科学 | 1889篇 |
皮肤病学 | 114篇 |
神经病学 | 435篇 |
特种医学 | 344篇 |
外科学 | 1803篇 |
综合类 | 37篇 |
预防医学 | 205篇 |
眼科学 | 102篇 |
药学 | 792篇 |
中国医学 | 5篇 |
肿瘤学 | 835篇 |
出版年
2023年 | 70篇 |
2022年 | 90篇 |
2021年 | 158篇 |
2020年 | 104篇 |
2019年 | 127篇 |
2018年 | 156篇 |
2017年 | 109篇 |
2016年 | 128篇 |
2015年 | 126篇 |
2014年 | 171篇 |
2013年 | 227篇 |
2012年 | 330篇 |
2011年 | 387篇 |
2010年 | 229篇 |
2009年 | 173篇 |
2008年 | 347篇 |
2007年 | 339篇 |
2006年 | 305篇 |
2005年 | 352篇 |
2004年 | 299篇 |
2003年 | 297篇 |
2002年 | 341篇 |
2001年 | 285篇 |
2000年 | 329篇 |
1999年 | 297篇 |
1998年 | 107篇 |
1997年 | 85篇 |
1996年 | 84篇 |
1995年 | 82篇 |
1994年 | 66篇 |
1993年 | 50篇 |
1992年 | 238篇 |
1991年 | 192篇 |
1990年 | 214篇 |
1989年 | 176篇 |
1988年 | 166篇 |
1987年 | 179篇 |
1986年 | 143篇 |
1985年 | 162篇 |
1984年 | 90篇 |
1983年 | 66篇 |
1982年 | 45篇 |
1979年 | 85篇 |
1978年 | 47篇 |
1977年 | 41篇 |
1974年 | 40篇 |
1973年 | 32篇 |
1972年 | 36篇 |
1970年 | 32篇 |
1969年 | 42篇 |
排序方式: 共有8499条查询结果,搜索用时 0 毫秒
121.
Guidelines for treatment of ulcerative colitis in children 总被引:2,自引:0,他引:2
Takeshi Tomomasa Akio Kobayashi Kousuke Ushijima Keiichi Uchida Seiichi Kagimoto Toshiaki Shimizu Hitoshi Tajiri Takuhiro Tahara Atushi Yoden for the Working Group of the Japanese Society for Pediatric Gastroenterology Hepatology Nutrition 《Pediatrics international》2004,46(4):494-496
This paper introduces the guidelines for treatment of ulcerative colitis in children, created by the working group of the Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition (Chair: Yuichiro Yamashiro) and the Japanese Society for Pediatric Inflammatory Bowel Disease (IBD) (Chair: Akio Kobayashi). The ideas of the working group, with regard to the fundamental differences in medical treatment between children and adults, included: (1) for children, intensive medical treatment including appropriate systemic management is important during the acute phase of illness. (2) Treatment with steroids, which can cause growth disturbances, should not be continued for long periods of time. (3) Pulsed steroid therapy, selective removal of blood cells, and intravenous infusion of cyclosporin should be included in the therapeutic option for severe and fluminant cases. 相似文献
122.
Mori H Uchida S Ohsawa H Noguchi E Kimura T Nishijo K 《Journal of the autonomic nervous system》2000,79(2-3):93-98
The effects of electro-acupuncture stimulation (EAS) of two different areas of a hindlimb with different stimulus intensities on sympathoadrenal medullary functions were examined in anesthetized artificially ventilated rats. Two needles of 160 microm diameter and about 5 mm apart were inserted about 5 mm deep into a hindpaw (Chungyang, S42) or a hind leg (Tsusanli, S36) and current of various intensities passed to excite various afferent nerve fiber groups at a repetition rate of 20 Hz and pulse duration of 0.5 ms for 30-60 s. Fiber groups of afferent nerves stimulated in a hindlimb were monitored by recording evoked action potentials from the afferents innervating the areas stimulated. The sympathoadrenal medullary functions were monitored by recording adrenal sympathetic efferent nerve activity and secretion rates of catecholamines from the adrenal medulla. EAS of a hindpaw at a stimulus strength sufficient to excite the group III and IV somatic afferent fibers produced reflex increases in both adrenal sympathetic efferent nerve activity and the secretion rate of catecholamines. EAS of a hind leg at a stimulus strength sufficient to excite the group III and IV afferent fibers produced reflex responses of either increases or decreases in sympathoadrenal medullary functions. All responses of adrenal sympathetic efferent nerve activity were lost after cutting the afferent nerves ipsilateral to the stimulated areas, indicating that the responses are the reflexes whose afferents nerve pathway is composed of hindlimb somatic nerves. It is concluded that electro-acupuncture stimulation of a hindpaw causes an excitatory reflex, while that of a hind leg causes either excitatory or inhibitory reflex of sympathoadrenal medullary functions, even if both group III and IV somatic afferent fibers are stimulated. 相似文献
123.
We investigated the correlation between clinical severity and striatal [123I]-CIT binding in 12 patients with Parkinson's Disease (PD: 6 men and 6 women, age: 65 +/- 7 years, Hoehn & Yahr stage: 1 to 3). The clinical severity of PD patients was measured with the Unified Parkinson's Disease Rating Scale (UPDRS) after withdrawal of antiparkinsonian medication at least 12 hours before assessment. [123I]beta-CIT binding in the caudate and putamen was measured at 3 hours [V'3 (day 1)], and at 24 hours [V'3 (day 2)) after tracer injection with small square ROIs. The specific striatal uptake index (day 2) was calculated with large square ROIs that encompassed the whole striatum. The best correlation (r = -0.82, p < 0.0012) was between putamenal V'3 (day 2) and the motor UPDRS scores. When the motor UPDRS scores were divided into four subscales, bradykinesia was the only sign that correlated significantly with putamenal V'3 (day 2) (r = -0.81, p < 0.002). [123I]beta-CIT SPECT is a useful marker of disease severity in PD with potential utility in the serial monitoring of disease progression. 相似文献
124.
Ohnishi Y Takauchi Y Kamei M Matumura Y Uchida O Kuro M Hayashi Y Mashimo T 《Masui. The Japanese journal of anesthesiology》2000,49(5):523-529
We experienced intraoperative anesthetic management of two cases of heart transplantation in Japan. Both patients were in the end stage of cardiac failure due to dilated cardiomyopathy. One patient had had implantation of left ventricular assist system, and another patient had had implantation of automated cardioveter defibrillator. Transesophageal echocardiography was useful for the monitoring of cardiac function during the operation. Anti-arrythmic therapy including heart pacing and protection of right heart failure are important for the circulatory management of heart transplantation. The anesthesiologist is needed not only for the management of respiration and circulation but also for the prevention of infection and control of the time schedule. 相似文献
125.
Takaaki Konuma Shohei Mizuno Tadakazu Kondo Yasuyuki Arai Naoyuki Uchida Satoshi Takahashi Masatsugu Tanaka Takuro Kuriyama Shigesaburo Miyakoshi Makoto Onizuka Shuichi Ota Yasuhiro Sugio Yasushi Kouzai Toshiro Kawakita Hikaru Kobayashi Yukiyasu Ozawa Takafumi Kimura Tatsuo Ichinohe Yoshiko Atsuta Masamitsu Yanada for the Adult Acute Myeloid Leukemia Working Group of the Japanese Society for Transplantation Cellular Therapy 《Blood cancer journal》2022,12(5)
Unrelated cord blood transplantation (CBT) is an alternative curative option for adult patients with acute myeloid leukemia (AML) who need allogeneic hematopoietic cell transplantation (HCT) but lack an HLA-matched related or unrelated donor. However, large-scale data are lacking on CBT outcomes for unselected adult AML. To investigate the trends of survival and engraftment after CBT over the past 22 years, we retrospectively evaluated the data of patients with AML in Japan according to the time period of CBT (1998–2007 vs 2008–2013 vs 2014–2019). A total of 5504 patients who received single-unit CBT as first allogeneic HCT for AML were included. Overall survival (OS) at 2 years significantly improved over time. The improved OS among patients in ≥ complete remission (CR)3 and active disease at CBT was mainly due to a reduction of relapse-related mortality, whereas among patients in first or second CR at CBT, this was due mainly to a reduction of non-relapse mortality. The trends of neutrophil engraftment also improved over time. This experience demonstrated that the survival and engraftment rate after CBT for this group has improved over the past 22 years.Subject terms: Acute myeloid leukaemia, Cancer immunotherapy 相似文献
126.
Shinichiro Asakawa Shigeyuki Arai Mika Kawagoe Chiaki Ohata Wataru Ono Hiroshi Murata Yoshifuru Tamura Shunya Uchida Shigeru Shibata Yoshihide Fujigaki 《Internal medicine (Tokyo, Japan)》2022,61(9):1423
A young woman with microscopic polyangiitis (MPA) requiring hemodialysis showed repeated posterior reversible encephalopathy syndrome (PRES) with spatiotemporal multiple lesions over a period of two months. The first PRES episode with confusion and the second PRES episode with vertigo and nausea were caused by MPA, hypertension and renal failure. These symptoms were improved by the reinforcement of MPA treatment and blood pressure management. The third PRES episode with nausea, headache, seizure and visual changes was induced by rituximab infusion and hypertension. The PRES was improved with blood pressure and convulsant management. These conditions are challenging to diagnose and treat. 相似文献
127.
Takayuki Fujii Masao Hagihara Keiko Mitamura Shiori Nakashima Shin Ohara Tomoyuki Uchida Morihiro Inoue Moe Okuda Atsuhiro Yasuhara Jurika Murakami Calvin Duong Kiyoko Iwatsuki-Horimoto Seiya Yamayoshi Yoshihiro Kawaoka 《Internal medicine (Tokyo, Japan)》2022,61(11):1681
Objective Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread globally. Although the relationship between anti-SARS-CoV-2 immunoglobulin G (IgG) antibodies and COVID-19 severity has been reported, information is lacking regarding the seropositivity of patients with particular types of diseases, including hematological diseases. Methods In this single-center, retrospective study, we compared SARS-CoV-2 IgG positivity between patients with hematological diseases and those with non-hematological diseases. Results In total, 77 adult COVID-19 patients were enrolled. Of these, 30 had hematological disorders, and 47 had non-hematological disorders. The IgG antibody against the receptor-binding domain of the spike protein was detected less frequently in patients with hematological diseases (60.0%) than in those with non-hematological diseases (91.5%; p=0.029). Rituximab use was significantly associated with seronegativity (p=0.010). Conclusion Patients with hematological diseases are less likely to develop anti-SARS-CoV-2 antibodies than those with non-hematological diseases, which may explain the poor outcomes of COVID-19 patients in this high-risk group. 相似文献
128.
T Ando S Okada I Uchida K Hemmi M Nishikawa Y Tsurumi A Fujie K Yoshida M Okuhara 《The Journal of antibiotics》1987,40(4):468-475
WF-10129 is an angiotensin converting enzyme (ACE) inhibitor produced by Doratomyces putredinis. IC50 of the compound is 1.4 X 10(-8) M for the ACE activity. WF-10129 was purified from cultured filtrate by successive ion exchange chromatography and HPLC. The chemical structure 1 was elucidated on the basis of spectroscopic and chemical evidence. The compound is a dipeptide composed of L-tyrosine and a novel amino acid. WF-10129 inhibits the pressor response of angiotensin I when administered intravenously at 0.3 mg/kg in rats. 相似文献
129.
O Nakayama M Yagi M Tanaka S Kiyoto I Uchida M Hashimoto M Okuhara M Kohsaka 《The Journal of antibiotics》1990,43(11):1394-1402
WS-7528, produced by Streptomyces sp. No. 7528, was extracted from cultured broth, purified by solvent extraction followed by chromatography on silica gel and then isolated as pale yellow powder (C16H14O5, mp 95-98 degrees C). WS-7528 inhibited estrogen binding to its receptor protein in rat uterine cytosol. The IC50 value of WS-7528 for partially purified rat uterine cytosol receptor was 5.7 x 10(-8) M. This compound was found to induce the growth of the estrogen dependent cell line MCF-7. WS-7528 was tested orally and subcutaneously in immature rats to confirm its effect on the growth of the uterus. WS-7528 has also weak anti-inflammatory activity on the carrageenin paw edema of the rat model. 相似文献
130.
Takahiro Matsui Akio Iwasa Masafumi Mimura Seiji Taniguchi Takao Sudo Yutaka Uchida Junichi Kikuta Hidetomo Morizono Rie Horii Yuichi Motoyama Eiichi Morii Shinji Ohno Yasujiro Kiyota Masaru Ishii 《Cancer science》2022,113(8):2916
Histopathological diagnosis is the ultimate method of attaining the final diagnosis; however, the observation range is limited to the two‐dimensional plane, and it requires thin slicing of the tissue, which limits diagnostic information. To seek solutions for these problems, we proposed a novel imaging‐based histopathological examination. We used the multiphoton excitation microscopy (MPM) technique to establish a method for visualizing unfixed/unstained human breast tissues. Under near‐infrared ray excitation, fresh human breast tissues emitted fluorescent signals with three major peaks, which enabled visualizing the breast tissue morphology without any fixation or dye staining. Our study using human breast tissue samples from 32 patients indicated that experienced pathologists can estimate normal or cancerous lesions using only these MPM images with a kappa coefficient of 1.0. Moreover, we developed an image classification algorithm with artificial intelligence that enabled us to automatically define cancer cells in small areas with a high sensitivity of ≥0.942. Taken together, label‐free MPM imaging is a promising method for the real‐time automatic diagnosis of breast cancer. 相似文献