全文获取类型
收费全文 | 12542篇 |
免费 | 636篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 76篇 |
儿科学 | 198篇 |
妇产科学 | 214篇 |
基础医学 | 1425篇 |
口腔科学 | 267篇 |
临床医学 | 821篇 |
内科学 | 3132篇 |
皮肤病学 | 169篇 |
神经病学 | 891篇 |
特种医学 | 508篇 |
外科学 | 2473篇 |
综合类 | 39篇 |
预防医学 | 275篇 |
眼科学 | 229篇 |
药学 | 930篇 |
中国医学 | 23篇 |
肿瘤学 | 1555篇 |
出版年
2023年 | 48篇 |
2022年 | 105篇 |
2021年 | 183篇 |
2020年 | 117篇 |
2019年 | 140篇 |
2018年 | 170篇 |
2017年 | 164篇 |
2016年 | 212篇 |
2015年 | 205篇 |
2014年 | 270篇 |
2013年 | 360篇 |
2012年 | 496篇 |
2011年 | 591篇 |
2010年 | 320篇 |
2009年 | 293篇 |
2008年 | 562篇 |
2007年 | 586篇 |
2006年 | 577篇 |
2005年 | 544篇 |
2004年 | 668篇 |
2003年 | 642篇 |
2002年 | 647篇 |
2001年 | 467篇 |
2000年 | 467篇 |
1999年 | 460篇 |
1998年 | 190篇 |
1997年 | 165篇 |
1996年 | 156篇 |
1995年 | 136篇 |
1994年 | 114篇 |
1993年 | 82篇 |
1992年 | 273篇 |
1991年 | 213篇 |
1990年 | 241篇 |
1989年 | 276篇 |
1988年 | 272篇 |
1987年 | 251篇 |
1986年 | 224篇 |
1985年 | 228篇 |
1984年 | 134篇 |
1983年 | 125篇 |
1982年 | 53篇 |
1981年 | 42篇 |
1979年 | 111篇 |
1978年 | 70篇 |
1977年 | 51篇 |
1972年 | 52篇 |
1971年 | 52篇 |
1970年 | 47篇 |
1969年 | 58篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
Hideki Aragane Hideki Fujii Takaharu You Atuhiro Morita Morimichi Miyazaki Kiyoshi Morita Tohru Ohkawara Shinji Fukumitu Yoshihiko Sawa Yasuo Ohkawara 《Nihon Shokakibyo Gakkai zasshi》2006,103(5):537-542
This report describes our experience with a 60 year old male who suffered from a recrudescence of groove pancreatitis. He had been treated by conservative medication therapy by proton pump inhibitor used for therapy of duodenal ulcer, and was in remission. During a follow-up one year later, endoscopy revealed gastric cancer, for which a proximal gastrectomy and vagotomy were performed. The patient continues to remain in remission for the groove pancreatitis. Our experience with the clinical course of this disease, in which treatment for duodenal ulcer was used effectively, offers new insights into the progression and therapy of groove pancreatitis. 相似文献
32.
33.
F Hashimoto Y Fujii M Toba H Okamatsu H Kohri 《Journal of nutritional science and vitaminology》1992,38(5):435-449
The absorption and endogenous excretion of iron in man was studied by monitoring the fecal excretion of a stable iron isotope (58Fe). The study was carried out for 12 healthy volunteers who were divided into two groups. Group I received 58Fe-labeled ferric ammonium citrate (III) (58FeAC) equivalent to 6 mg of iron as a control, and group II received a combination of 500 mg of vitamin C and 58FeAC. A new formula was used to calculate the 58Fe absorption ratio reflecting the pool of iron in the intestinal cells, and the ratio was compared with that obtained from Janghorbani's formula, which has been used as one of the common methods. As a result, the 58Fe absorption ratio in group II was statistically significantly higher than that of group I (34.4 +/- 6.1% vs. 15.0 +/- 5.5%, M +/- SD) using Janghorbani's formula. The similar absorption ratio (34.1 +/- 6.0% vs. 14.8 +/- 5.5%) was also obtained by our new formula. Our results confirmed the previous findings that the availability of iron is stimulated by the supplementation of vitamin C. Both formulae agreed in the absorption of iron, indicating that the endogenous excretion of iron (caused by the desquamated cells) in the intestine does not disguise the iron absorption. 相似文献
34.
A Yamashita T Kurokawa Y Fujii H Yasuda S Ishibashi 《European journal of pharmacology》1990,188(4-5):229-234
The effect of alkaline phosphatase (3.1.3.1) on desensitization of beta-adrenoceptor-responsive adenylate cyclase and the role of phosphorylation in desensitization were examined. Treatment of rat reticulocytes with isoproterenol, dibutyryl cAMP and tetradecanoyl phorbol acetate (TPA) caused the desensitization of beta-adrenoceptor-coupled adenylate cyclase. When the membranes from dibutyryl cAMP- and TPA-desensitized cells were incubated with alkaline phosphatase for 60 min at 30 degrees C, pH 8.0, the desensitization of isoproterenol-stimulated adenylate cyclase was markedly attenuated in both preparations. When the membranes from isoproterenol-desensitized cells were treated with alkaline phosphatase under the same conditions, the attenuation of the desensitization of alkaline phosphatase was less than in the case of treatment with dibutyryl cAMP or TPA. In other words, isoproterenol-induced desensitization was more resistant to alkaline phosphatase treatment. Isoproterenol- and dibutyryl cAMP-induced desensitization of NaF-stimulated adenylate cyclase were also attenuated by alkaline phosphatase treatment. Although the stability of the Gs-catalytic unit complex of adenylate cyclase was reduced by isoproterenol treatment, the reduction of stability was also decreased by alkaline phosphatase treatment. 相似文献
35.
We examined the effects of dopamine (DOA) 10 μg·kg−1·min−1 I.V. and dobutamine (DOB) 10 μg·kg−1. min−1 I.V. on the contractility of the fatigued diaphragm in 26 anesthetized, mechanically ventilated dogs. Animals were divided
into two groups of 13 each: the DOA and DOB groups. Diaphragmatic fatigue was induced by intermittent supramaximal bilateral
electrophrenic stimulation at a frequency of 20 Hz applied for 30 min. Diaphragmatic contractility was assessed from changes
in transdiaphragmatic pressure (Pdi). After diaphragmatic fatigue, Pdi at low-frequency (20 Hz) stimulation decreased significantly compared with the prefatigue value (P<0.05), whereas no change in Pdi was observed at high-frequency (100 Hz) stimulation. In the fatigued diaphragm, Pdi at both stimuli increased with an infusion of either DOA (P<0.05) or DOB (P<0.05). The increase of Pdi at 20 Hz stimulation was significantly larger in the DOB group compared with that of the DOA group (P<0.05). In each group, Pdi at both stimuli decreased after the cessation of administration. The integrated diaphragmatic electric activity (Edi) in the two groups did not change at any frequency of stimulation throughout the study. We conclude that DOB in comparison
with DOA is more effective in improving the contractility of the fatigued diaphragm. 相似文献
36.
37.
K Imataka H Sakamoto H Nishimura K Ieki J Fujii 《Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics》1992,29(6):503-508
The admission of antihypertensive medications in the elderly (65 y.o. or more, 269 pts) was compared to that in younger cases (less than 65 y.o., 348 pts). All were outpatients who visited our clinic in 1990. The number of patients on a single therapeutic regimen was almost equal in both age groups. Once-a-day regimens were more common in the young (56.9% vs 48.3%, p less than 0.05), and three times-a-day regimens were more common in the elderly (14.7% vs 23.1%, p less than 0.01). The choice of antihypertensive drugs in patients with single therapy or combined therapy in the young was beta blockers in 49.7%, Ca blockers in 39.4%, diuretics in 30.7% and ACE inhibitors in 17.8%, and those in the elderly were Ca blockers in 46.1%, diuretics in 44.2%, beta blockers in 33.8%, and ACE inhibitors in 16.4%. The patients were subdivided into three groups according to the time of the initial visit to the clinic; initial visit during 1969-1979 (phase 1), 1980-1984 (phase 2) and 1985-1990 (phase 3). In the young, choice of beta blockers and diuretics was most popular in phase 1. However, the choice of diuretics decreased in phase 2, and in phase 3 beta blockers were used in 50.4%, Ca blockers in 43.2%, ACE inhibitors in 22.3% and diuretics in only 17.3%. In the elderly, diuretics were most popular followed by Ca blockers and beta blockers in phase 1 and phase 2. In phase 3 Ca blockers were selected in 58.2% followed by both beta blockers and ACE inhibitors in 28.4% then diuretics in 23.9%.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
38.
E Miyoshi J Fujii N Hayashi K Ueda T Towata H Fusamoto T Kamada N Taniguchi 《International journal of cancer. Journal international du cancer》1992,52(1):137-140
The human hepatoblastoma-derived cell line HB611 secretes hepatitis-B surface antigen (HBsAg) and hepatitis-B e antigen (HBeAg) into the medium. Hepatitis-B-virus (HBV) DNA integrated into the cellular genome was found to be hypermethylated. When the cells were treated with 5-azacytidine for 3 days, the level of HBsAg in the medium increased, while the level of HBeAg remained constant. The level of alpha-fetoprotein (AFP) decreased with the 5-azacytidine treatment. Southern blot analysis of DNA digested with HpaII or MspI showed that 5-azacytidine treatment resulted in hypomethylation of the integrated HBV DNA, suggesting that 5-azacytidine increased HBsAg production in the cells through hypomethylation of the HBV genomic DNA. 相似文献
39.
Toshiji Ishiwata Ryo Koyama Noriyuki Homma Mitsuhiro Fujii Naoko Iwakami Yuta Nakao Shin-ichiro Iwakami Kazuhisa Takahashi 《Nihon Kokyūki Gakkai zasshi》2006,44(10):749-753
A 28-year-old man complaining of myiodesopsia was given a diagnosis of uveitis. Subsequently he complained facial nerve palsy and enlargement of parotid gland. Heerfordt's syndrome was diagnosed based on the results of several examinations. Facial nerve palsy, enlargement of the parotid gland and uveitis were improved by systemic corticosteroid therapy. At present he is receiving systemic corticosteroid therapy, but numbness in the mouth, thought to be the involvement of the trigeminal nerve, remains. Systemic corticosteroid therapy is usually effective for most cases with Heerford's syndrome. On the other hand, there are some cases with the prolonged peripheral nerve involvement despite systemic corticosteroid therapy, as seen in this case. If peripheral nerve involvement is prolonged, it is necessary to consider small-fibre neuropathy as one possible cause. 相似文献
40.
The threshold beta-ray energy for Cerenkov photon production can be reduced to about 0.07 MeV by using a transparent ceramic with a high refractive index. This makes it possible to measure the low-energy beta-emitters 14C and 45Ca by Cerenkov counting with efficiencies of 1.5% and 2.3%, respectively. 相似文献